Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder
International audience Dietary intake of omega-3 fatty acids has been positively correlated with cardiovascular and neuropsychiatric health in several studies. The high seafood intake by the Japanese and Greenland Inuit has resulted in low ratios of the omega-6 fatty acid arachidonic acid (AA, 20:4n...
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Online Access: | https://hal.science/hal-00900582 https://hal.science/hal-00900582/document https://hal.science/hal-00900582/file/hal-00900582.pdf https://doi.org/10.1051/rnd:2005045 |
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ftccsdartic:oai:HAL:hal-00900582v1 2023-11-12T04:16:44+01:00 Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder Young, Genevieve Conquer, Julie Thomas, René 2005 https://hal.science/hal-00900582 https://hal.science/hal-00900582/document https://hal.science/hal-00900582/file/hal-00900582.pdf https://doi.org/10.1051/rnd:2005045 en eng HAL CCSD EDP Sciences info:eu-repo/semantics/altIdentifier/doi/10.1051/rnd:2005045 hal-00900582 https://hal.science/hal-00900582 https://hal.science/hal-00900582/document https://hal.science/hal-00900582/file/hal-00900582.pdf doi:10.1051/rnd:2005045 info:eu-repo/semantics/OpenAccess ISSN: 0926-5287 EISSN: 1297-9708 Reproduction Nutrition Development https://hal.science/hal-00900582 Reproduction Nutrition Development, 2005, 45 (5), pp.549-558. ⟨10.1051/rnd:2005045⟩ omega-3 fatty acids fish oil flax oil attention deficit hyperactivity disorder adults [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition [SDV.BDD]Life Sciences [q-bio]/Development Biology info:eu-repo/semantics/article Journal articles 2005 ftccsdartic https://doi.org/10.1051/rnd:2005045 2023-10-21T22:26:00Z International audience Dietary intake of omega-3 fatty acids has been positively correlated with cardiovascular and neuropsychiatric health in several studies. The high seafood intake by the Japanese and Greenland Inuit has resulted in low ratios of the omega-6 fatty acid arachidonic acid (AA, 20:4n-6) to eicosapentaenoic acid (EPA, 20:5n-3), with the Japanese showing AA:EPA ratios of approximately 1.7 and the Greenland Eskimos showing ratios of approximately 0.14. It was the objective of this study to determine the effect of supplementation with high doses (60 g) of flax and fish oils on the blood phospholipid (PL) fatty acid status, and AA/EPA ratio of individuals with Attention Deficit Hyperactivity Disorder (ADHD), commonly associated with decreased blood omega-3 fatty acid levels. Thirty adults with ADHD were randomized to 12 weeks of supplementation with olive oil (< 1% omega-3 fatty acids), flax oil (source of alpha-linolenic acid; 18:3n-3; $\alpha$-LNA) or fish oil (source of EPA and docosahexaenoic acid; 22:6n-3; DHA). Serum PL fatty acid levels were determined at baseline and at 12 weeks. Flax oil supplementation resulted in an increase in $\alpha$-LNA and a slight decrease in the ratio of AA/EPA, while fish oil supplementation resulted in increases in EPA, DHA and total omega-3 fatty acids and a decrease in the AA/EPA ratio to values seen in the Japanese population. These data suggest that in order to increase levels of EPA and DHA in adults with ADHD, and decrease the AA/EPA ratio to levels seen in high fish consuming populations, high dose fish oil may be preferable to high dose flax oil. Future study is warranted to determine whether correction of low levels of long-chain omega-3 fatty acids is of therapeutic benefit in this population. Article in Journal/Newspaper eskimo* Greenland inuit Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Greenland |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
omega-3 fatty acids fish oil flax oil attention deficit hyperactivity disorder adults [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition [SDV.BDD]Life Sciences [q-bio]/Development Biology |
spellingShingle |
omega-3 fatty acids fish oil flax oil attention deficit hyperactivity disorder adults [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition [SDV.BDD]Life Sciences [q-bio]/Development Biology Young, Genevieve Conquer, Julie Thomas, René Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder |
topic_facet |
omega-3 fatty acids fish oil flax oil attention deficit hyperactivity disorder adults [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition [SDV.BDD]Life Sciences [q-bio]/Development Biology |
description |
International audience Dietary intake of omega-3 fatty acids has been positively correlated with cardiovascular and neuropsychiatric health in several studies. The high seafood intake by the Japanese and Greenland Inuit has resulted in low ratios of the omega-6 fatty acid arachidonic acid (AA, 20:4n-6) to eicosapentaenoic acid (EPA, 20:5n-3), with the Japanese showing AA:EPA ratios of approximately 1.7 and the Greenland Eskimos showing ratios of approximately 0.14. It was the objective of this study to determine the effect of supplementation with high doses (60 g) of flax and fish oils on the blood phospholipid (PL) fatty acid status, and AA/EPA ratio of individuals with Attention Deficit Hyperactivity Disorder (ADHD), commonly associated with decreased blood omega-3 fatty acid levels. Thirty adults with ADHD were randomized to 12 weeks of supplementation with olive oil (< 1% omega-3 fatty acids), flax oil (source of alpha-linolenic acid; 18:3n-3; $\alpha$-LNA) or fish oil (source of EPA and docosahexaenoic acid; 22:6n-3; DHA). Serum PL fatty acid levels were determined at baseline and at 12 weeks. Flax oil supplementation resulted in an increase in $\alpha$-LNA and a slight decrease in the ratio of AA/EPA, while fish oil supplementation resulted in increases in EPA, DHA and total omega-3 fatty acids and a decrease in the AA/EPA ratio to values seen in the Japanese population. These data suggest that in order to increase levels of EPA and DHA in adults with ADHD, and decrease the AA/EPA ratio to levels seen in high fish consuming populations, high dose fish oil may be preferable to high dose flax oil. Future study is warranted to determine whether correction of low levels of long-chain omega-3 fatty acids is of therapeutic benefit in this population. |
format |
Article in Journal/Newspaper |
author |
Young, Genevieve Conquer, Julie Thomas, René |
author_facet |
Young, Genevieve Conquer, Julie Thomas, René |
author_sort |
Young, Genevieve |
title |
Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder |
title_short |
Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder |
title_full |
Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder |
title_fullStr |
Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder |
title_full_unstemmed |
Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder |
title_sort |
effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder |
publisher |
HAL CCSD |
publishDate |
2005 |
url |
https://hal.science/hal-00900582 https://hal.science/hal-00900582/document https://hal.science/hal-00900582/file/hal-00900582.pdf https://doi.org/10.1051/rnd:2005045 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland inuit |
genre_facet |
eskimo* Greenland inuit |
op_source |
ISSN: 0926-5287 EISSN: 1297-9708 Reproduction Nutrition Development https://hal.science/hal-00900582 Reproduction Nutrition Development, 2005, 45 (5), pp.549-558. ⟨10.1051/rnd:2005045⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1051/rnd:2005045 hal-00900582 https://hal.science/hal-00900582 https://hal.science/hal-00900582/document https://hal.science/hal-00900582/file/hal-00900582.pdf doi:10.1051/rnd:2005045 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1051/rnd:2005045 |
_version_ |
1782333818937540608 |