Body Temperature during hibernation is highly correlated with a decrease in circulating innate immune cells in the brown bear (Ursus arctos): a common feature among hibernators?
International audience Background: Hibernation involves periods of severely depressed metabolism (torpor) and decreases in body temperature (Tb). Small arctic mammals ( < 5kg), in which Tb generally drop drastically, display leukopenia during hibernation. This raised the question of whether the d...
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Online Access: | https://hal.science/hal-00805200 https://hal.science/hal-00805200/document https://hal.science/hal-00805200/file/Sahdo.pdf https://doi.org/10.7150/ijms.4476 |
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ftccsdartic:oai:HAL:hal-00805200v1 2024-02-11T10:01:33+01:00 Body Temperature during hibernation is highly correlated with a decrease in circulating innate immune cells in the brown bear (Ursus arctos): a common feature among hibernators? Sahdo, Berolla L. Evans, Alina M. Arnemo, Jon Fröbert, Ole Särndahl, Eva Blanc, Stéphane Department of Clinical Medicine Örebro University Department of Forestry and Wildlife Management Hedmark University College Section of Arctic Veterinary medicine Norwegian School of Veterinary Science Department of Wildlife, Fish and Environmental Studies Swedish University of Agricultural Sciences (SLU) Department of Cardiology Département Ecologie, Physiologie et Ethologie (DEPE-IPHC) Institut Pluridisciplinaire Hubert Curien (IPHC) Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) 2013 https://hal.science/hal-00805200 https://hal.science/hal-00805200/document https://hal.science/hal-00805200/file/Sahdo.pdf https://doi.org/10.7150/ijms.4476 en eng HAL CCSD Ivyspring International Publisher info:eu-repo/semantics/altIdentifier/doi/10.7150/ijms.4476 hal-00805200 https://hal.science/hal-00805200 https://hal.science/hal-00805200/document https://hal.science/hal-00805200/file/Sahdo.pdf doi:10.7150/ijms.4476 info:eu-repo/semantics/OpenAccess ISSN: 1449-1907 International Journal of Medical Sciences https://hal.science/hal-00805200 International Journal of Medical Sciences, 2013, 10 (5), pp.508-514. ⟨10.7150/ijms.4476⟩ brown bear Ursus arctos Hibernation Innate immunity Leukocytes Torpor [SDE]Environmental Sciences [SDV.BA]Life Sciences [q-bio]/Animal biology info:eu-repo/semantics/article Journal articles 2013 ftccsdartic https://doi.org/10.7150/ijms.4476 2024-01-27T23:32:57Z International audience Background: Hibernation involves periods of severely depressed metabolism (torpor) and decreases in body temperature (Tb). Small arctic mammals ( < 5kg), in which Tb generally drop drastically, display leukopenia during hibernation. This raised the question of whether the decreased leukocyte counts in mammalian hibernators is due to torpor per se or is secondary to low Tb. The present study examined immune cell counts in brown bears (Ursus arctos), where torpor is only associated with shallow decreases in Tb. The results were compared across hibernator species for which immune and Tb data were available. Methods and Results: The white blood cell counts were determined by flow cytometry in 13 bears captured in the field both during summer and winter over 2 years time. Tb dropped from 39.6±0.8 to 33.5±1.1°C during hibernation. Blood neutrophils and monocytes were lower during hibernation than during the active period (47%, p= 0.001; 43%, p=0.039, respectively), whereas no change in lymphocyte counts was detected (p=0.599). Further, combining our data and those from 10 studies on 9 hibernating species suggested that the decline in Tb explained the decrease in innate immune cells (R2=0.83, p < 0.0001). Conclusions: Bears have fewer innate immune cells in circulation during hibernation, which may represent a suppressed innate immune system. Across species comparison suggests that, both in small and large hibernators, Tb is the main driver of immune function regulation during winter dormancy. The lack of a difference in lymphocyte counts in this context requires further investigations. Article in Journal/Newspaper Arctic brown bear Ursus arctos Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Arctic International Journal of Medical Sciences 10 5 508 514 |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
brown bear Ursus arctos Hibernation Innate immunity Leukocytes Torpor [SDE]Environmental Sciences [SDV.BA]Life Sciences [q-bio]/Animal biology |
spellingShingle |
brown bear Ursus arctos Hibernation Innate immunity Leukocytes Torpor [SDE]Environmental Sciences [SDV.BA]Life Sciences [q-bio]/Animal biology Sahdo, Berolla L. Evans, Alina M. Arnemo, Jon Fröbert, Ole Särndahl, Eva Blanc, Stéphane Body Temperature during hibernation is highly correlated with a decrease in circulating innate immune cells in the brown bear (Ursus arctos): a common feature among hibernators? |
topic_facet |
brown bear Ursus arctos Hibernation Innate immunity Leukocytes Torpor [SDE]Environmental Sciences [SDV.BA]Life Sciences [q-bio]/Animal biology |
description |
International audience Background: Hibernation involves periods of severely depressed metabolism (torpor) and decreases in body temperature (Tb). Small arctic mammals ( < 5kg), in which Tb generally drop drastically, display leukopenia during hibernation. This raised the question of whether the decreased leukocyte counts in mammalian hibernators is due to torpor per se or is secondary to low Tb. The present study examined immune cell counts in brown bears (Ursus arctos), where torpor is only associated with shallow decreases in Tb. The results were compared across hibernator species for which immune and Tb data were available. Methods and Results: The white blood cell counts were determined by flow cytometry in 13 bears captured in the field both during summer and winter over 2 years time. Tb dropped from 39.6±0.8 to 33.5±1.1°C during hibernation. Blood neutrophils and monocytes were lower during hibernation than during the active period (47%, p= 0.001; 43%, p=0.039, respectively), whereas no change in lymphocyte counts was detected (p=0.599). Further, combining our data and those from 10 studies on 9 hibernating species suggested that the decline in Tb explained the decrease in innate immune cells (R2=0.83, p < 0.0001). Conclusions: Bears have fewer innate immune cells in circulation during hibernation, which may represent a suppressed innate immune system. Across species comparison suggests that, both in small and large hibernators, Tb is the main driver of immune function regulation during winter dormancy. The lack of a difference in lymphocyte counts in this context requires further investigations. |
author2 |
Department of Clinical Medicine Örebro University Department of Forestry and Wildlife Management Hedmark University College Section of Arctic Veterinary medicine Norwegian School of Veterinary Science Department of Wildlife, Fish and Environmental Studies Swedish University of Agricultural Sciences (SLU) Department of Cardiology Département Ecologie, Physiologie et Ethologie (DEPE-IPHC) Institut Pluridisciplinaire Hubert Curien (IPHC) Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) |
format |
Article in Journal/Newspaper |
author |
Sahdo, Berolla L. Evans, Alina M. Arnemo, Jon Fröbert, Ole Särndahl, Eva Blanc, Stéphane |
author_facet |
Sahdo, Berolla L. Evans, Alina M. Arnemo, Jon Fröbert, Ole Särndahl, Eva Blanc, Stéphane |
author_sort |
Sahdo, Berolla |
title |
Body Temperature during hibernation is highly correlated with a decrease in circulating innate immune cells in the brown bear (Ursus arctos): a common feature among hibernators? |
title_short |
Body Temperature during hibernation is highly correlated with a decrease in circulating innate immune cells in the brown bear (Ursus arctos): a common feature among hibernators? |
title_full |
Body Temperature during hibernation is highly correlated with a decrease in circulating innate immune cells in the brown bear (Ursus arctos): a common feature among hibernators? |
title_fullStr |
Body Temperature during hibernation is highly correlated with a decrease in circulating innate immune cells in the brown bear (Ursus arctos): a common feature among hibernators? |
title_full_unstemmed |
Body Temperature during hibernation is highly correlated with a decrease in circulating innate immune cells in the brown bear (Ursus arctos): a common feature among hibernators? |
title_sort |
body temperature during hibernation is highly correlated with a decrease in circulating innate immune cells in the brown bear (ursus arctos): a common feature among hibernators? |
publisher |
HAL CCSD |
publishDate |
2013 |
url |
https://hal.science/hal-00805200 https://hal.science/hal-00805200/document https://hal.science/hal-00805200/file/Sahdo.pdf https://doi.org/10.7150/ijms.4476 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic brown bear Ursus arctos |
genre_facet |
Arctic brown bear Ursus arctos |
op_source |
ISSN: 1449-1907 International Journal of Medical Sciences https://hal.science/hal-00805200 International Journal of Medical Sciences, 2013, 10 (5), pp.508-514. ⟨10.7150/ijms.4476⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.7150/ijms.4476 hal-00805200 https://hal.science/hal-00805200 https://hal.science/hal-00805200/document https://hal.science/hal-00805200/file/Sahdo.pdf doi:10.7150/ijms.4476 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.7150/ijms.4476 |
container_title |
International Journal of Medical Sciences |
container_volume |
10 |
container_issue |
5 |
container_start_page |
508 |
op_container_end_page |
514 |
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