A Genome-Wide Study of Panic Disorder Suggests the Amiloride-Sensitive Cation Channel 1 as a Candidate Gene

International audience Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors as wel...

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Bibliographic Details
Published in:European Journal of Human Genetics
Main Authors: Gregersen, Noomi, Dahl, Hans Atli, Buttenschøn, Henriette N., Nyegaard, Mette, Hedemand, Anne, Als, Thomas D., Wang, August G., Joensen, Sofus, Woldbye, David P. D., Koefoed, Pernille, Kristensen, Ann S., Kruse, Torben Arvid, Børglum, Anders D., Mors, Ole
Other Authors: Centre for Psychiatric Research
Format: Article in Journal/Newspaper
Language:English
Published: HAL CCSD 2011
Subjects:
Panic disorder
genome-wide scan
ACCN1
[SDV.GEN]Life Sciences [q-bio]/Genetics
Faroe Islands
Online Access:https://hal.archives-ouvertes.fr/hal-00665874
https://hal.archives-ouvertes.fr/hal-00665874/document
https://hal.archives-ouvertes.fr/hal-00665874/file/PEER_stage2_10.1038%252Fejhg.2011.148.pdf
https://doi.org/10.1038/ejhg.2011.148
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Summary:International audience Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine-mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case-control sample. However, analyses of a larger independent Danish case-control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population.

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