Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
International audience We introduce a general test of the bioenergetic importance of mitochondrial DNA variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mitochondrial DNA. We apply this test to the hypothesis [Ru...
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Online Access: | https://hal.archives-ouvertes.fr/hal-00478688 https://hal.archives-ouvertes.fr/hal-00478688/document https://hal.archives-ouvertes.fr/hal-00478688/file/PEER_stage2_10.1042%252FBJ20061609.pdf https://doi.org/10.1042/BJ20061609 |
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ftccsdartic:oai:HAL:hal-00478688v1 2023-05-15T15:01:31+02:00 Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines Amo, Taku Brand, Martin D Dunn Human Nutrition Unit MRC 2007-03-13 https://hal.archives-ouvertes.fr/hal-00478688 https://hal.archives-ouvertes.fr/hal-00478688/document https://hal.archives-ouvertes.fr/hal-00478688/file/PEER_stage2_10.1042%252FBJ20061609.pdf https://doi.org/10.1042/BJ20061609 en eng HAL CCSD Portland Press info:eu-repo/semantics/altIdentifier/doi/10.1042/BJ20061609 hal-00478688 https://hal.archives-ouvertes.fr/hal-00478688 https://hal.archives-ouvertes.fr/hal-00478688/document https://hal.archives-ouvertes.fr/hal-00478688/file/PEER_stage2_10.1042%252FBJ20061609.pdf doi:10.1042/BJ20061609 info:eu-repo/semantics/OpenAccess ISSN: 0264-6021 EISSN: 1470-8728 Biochemical Journal https://hal.archives-ouvertes.fr/hal-00478688 Biochemical Journal, Portland Press, 2007, 404 (2), pp.345-351. ⟨10.1042/BJ20061609⟩ Life Sciences info:eu-repo/semantics/article Journal articles 2007 ftccsdartic https://doi.org/10.1042/BJ20061609 2020-12-26T08:30:02Z International audience We introduce a general test of the bioenergetic importance of mitochondrial DNA variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mitochondrial DNA. We apply this test to the hypothesis [Ruiz-Pesini, Mishmar, Brandon, Procaccio and Wallace (2004) Science 303, 223-226] that particular mitochondrial DNA haplogroups (specific combinations of polymorphisms) that cause lowered coupling efficiency, leading to generation of less ATP and more heat, were positively selected during radiations of modern humans into colder climates. Contrary to the predictions of this hypothesis, mitochondria from Arctic haplogroups had similar or even greater coupling efficiency than mitochondria from tropical haplogroups. Article in Journal/Newspaper Arctic Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Arctic Biochemical Journal 404 2 345 351 |
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Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
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language |
English |
topic |
Life Sciences |
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Life Sciences Amo, Taku Brand, Martin D Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
topic_facet |
Life Sciences |
description |
International audience We introduce a general test of the bioenergetic importance of mitochondrial DNA variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mitochondrial DNA. We apply this test to the hypothesis [Ruiz-Pesini, Mishmar, Brandon, Procaccio and Wallace (2004) Science 303, 223-226] that particular mitochondrial DNA haplogroups (specific combinations of polymorphisms) that cause lowered coupling efficiency, leading to generation of less ATP and more heat, were positively selected during radiations of modern humans into colder climates. Contrary to the predictions of this hypothesis, mitochondria from Arctic haplogroups had similar or even greater coupling efficiency than mitochondria from tropical haplogroups. |
author2 |
Dunn Human Nutrition Unit MRC |
format |
Article in Journal/Newspaper |
author |
Amo, Taku Brand, Martin D |
author_facet |
Amo, Taku Brand, Martin D |
author_sort |
Amo, Taku |
title |
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
title_short |
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
title_full |
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
title_fullStr |
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
title_full_unstemmed |
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
title_sort |
were inefficient mitochondrial haplogroups selected during migrations of modern humans? a test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
publisher |
HAL CCSD |
publishDate |
2007 |
url |
https://hal.archives-ouvertes.fr/hal-00478688 https://hal.archives-ouvertes.fr/hal-00478688/document https://hal.archives-ouvertes.fr/hal-00478688/file/PEER_stage2_10.1042%252FBJ20061609.pdf https://doi.org/10.1042/BJ20061609 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
ISSN: 0264-6021 EISSN: 1470-8728 Biochemical Journal https://hal.archives-ouvertes.fr/hal-00478688 Biochemical Journal, Portland Press, 2007, 404 (2), pp.345-351. ⟨10.1042/BJ20061609⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1042/BJ20061609 hal-00478688 https://hal.archives-ouvertes.fr/hal-00478688 https://hal.archives-ouvertes.fr/hal-00478688/document https://hal.archives-ouvertes.fr/hal-00478688/file/PEER_stage2_10.1042%252FBJ20061609.pdf doi:10.1042/BJ20061609 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1042/BJ20061609 |
container_title |
Biochemical Journal |
container_volume |
404 |
container_issue |
2 |
container_start_page |
345 |
op_container_end_page |
351 |
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1766333535807864832 |