Comparison of First Nations and non-First Nations children's profiles with bronchiectasis over two five-year periods from the Northern Territory, Australia

• Published in: Chest
• Main Authors: McCallum, Gabrielle B, Oguoma, Victor M, Versteegh, Lesley A, Wilson, Cate A, Bauert, Paul, Spain, Brian, Chang, Anne B
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2021
• Subjects: First Nations
• Online Access: https://researchprofiles.canberra.edu.au/en/publications/a141b8ff-ca02-43d3-9809-c33d44c81251; https://doi.org/10.1016/j.chest.2021.04.057; https://researchsystem.canberra.edu.au/ws/files/45435654/1_s2.0_S0012369221008655_main.pdf; http://www.scopus.com/inward/record.url?scp=85115937414&partnerID=8YFLogxK

BACKGROUND: Although the burden of bronchiectasis is globally recognised, there is limited paediatric data particularly on trends over the years. There is also no published data on whether vitamin D deficiency/insufficiency and human T-cell lymphotropic virus type 1 (HTLV-1) infection, both found to relate with severe bronchiectasis in First Nations adults, is also important in children with bronchiectasis. RESEARCH QUESTION: Among children with bronchiectasis, has (a) the clinical and bronchoalveolar lavage (BAL) profiles changed between two 5-year periods (period-1=2007-11, period-2=2012-16); and (b) is vitamin D deficiency/insufficiency and/or HTLV-1 infection associated with radiological severity of bronchiectasis? STUDY DESIGN AND METHODS: We analysed the data from children with bronchiectasis prospectively enrolled at Royal Darwin Hospital, Australia at their first diagnosis i.e. no child was in both time-periods. Data collected include demographics, BAL, bloods and computed tomography chest scan evaluated using the Bhalla and modified Bhalla scores. RESULTS: The median age of the 299 children was 2.2 years (interquartile range 1.5-3.7), 168 (56%) males and most were First Nations (92%). Overall, bronchiectasis was high over time, particularly among First Nations children. In the later period, numbers of non-First Nations more than tripled, but did not reach statistical significance. In period-2 compared to period-1, fewer First Nations children had chronic cough (period-1=61%, period-2=47%, p=0.03), were younger, less likely to have received azithromycin (period-1=42%, period-2=21%, p<0.001) and their BAL had lower Haemophilus influenzae and Moraxella catarrhalis infection. HTLV-1 was not detected and vitamin D deficiency/insufficiency did not correlate with severity of bronchiectasis. INTERPRETATION: Bronchiectasis remains high particularly among First Nations children. Important changes that arguably reflect improvements were present, but overall, profiles remained similar. Although Vitamin D ...