The genetics of neural tube defects and twinning /
Several investigators have suggested that "upper" neural tube defects (NTD's)--anencephaly, encephalocele, and thoracic spina bifida--are etiologically different from "lower" NTD's (lumbo-sacral spina bifida). This hypothesis was primarily based on the observations that...
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ftcanadathes:oai:collectionscanada.gc.ca:QMM.56978 2023-05-15T17:22:16+02:00 The genetics of neural tube defects and twinning / Garabedian, Berdj Hratchia Fraser, F. Clarke (advisor) Master of Science (Department of Biology.) 1992 application/pdf http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56978 en eng McGill University alephsysno: 001325466 proquestno: AAIMM87719 Theses scanned by UMI/ProQuest. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56978 All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. Neural tube -- Abnormalities Twins Electronic Thesis or Dissertation 1992 ftcanadathes 2014-02-16T00:51:56Z Several investigators have suggested that "upper" neural tube defects (NTD's)--anencephaly, encephalocele, and thoracic spina bifida--are etiologically different from "lower" NTD's (lumbo-sacral spina bifida). This hypothesis was primarily based on the observations that the two types have different sex ratios and recurrence rates and that the NTD cases within one sibship are concordant for NTD type. In order to test this, the above figures were calculated in a sample of NTD probands from Montreal and Newfoundland. The findings were not consistent with the hypothesis. However, a previously unreported finding was observed: the frequency of twinning was significantly higher in the near relatives of upper NTD probands than in those of lower NTD probands or of controls. This curious association between upper NTD's and twinning may be explained by a familial factor predisposing to a delay early in development. This delay could also explain any differences observed in upper and lower NTD groups. Thesis Newfoundland Theses Canada/Thèses Canada (Library and Archives Canada) |
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Theses Canada/Thèses Canada (Library and Archives Canada) |
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English |
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Neural tube -- Abnormalities Twins |
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Neural tube -- Abnormalities Twins Garabedian, Berdj Hratchia The genetics of neural tube defects and twinning / |
topic_facet |
Neural tube -- Abnormalities Twins |
description |
Several investigators have suggested that "upper" neural tube defects (NTD's)--anencephaly, encephalocele, and thoracic spina bifida--are etiologically different from "lower" NTD's (lumbo-sacral spina bifida). This hypothesis was primarily based on the observations that the two types have different sex ratios and recurrence rates and that the NTD cases within one sibship are concordant for NTD type. In order to test this, the above figures were calculated in a sample of NTD probands from Montreal and Newfoundland. The findings were not consistent with the hypothesis. However, a previously unreported finding was observed: the frequency of twinning was significantly higher in the near relatives of upper NTD probands than in those of lower NTD probands or of controls. This curious association between upper NTD's and twinning may be explained by a familial factor predisposing to a delay early in development. This delay could also explain any differences observed in upper and lower NTD groups. |
author2 |
Fraser, F. Clarke (advisor) |
format |
Thesis |
author |
Garabedian, Berdj Hratchia |
author_facet |
Garabedian, Berdj Hratchia |
author_sort |
Garabedian, Berdj Hratchia |
title |
The genetics of neural tube defects and twinning / |
title_short |
The genetics of neural tube defects and twinning / |
title_full |
The genetics of neural tube defects and twinning / |
title_fullStr |
The genetics of neural tube defects and twinning / |
title_full_unstemmed |
The genetics of neural tube defects and twinning / |
title_sort |
genetics of neural tube defects and twinning / |
publisher |
McGill University |
publishDate |
1992 |
url |
http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56978 |
op_coverage |
Master of Science (Department of Biology.) |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_relation |
alephsysno: 001325466 proquestno: AAIMM87719 Theses scanned by UMI/ProQuest. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56978 |
op_rights |
All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
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1766108782846279680 |