The relative estrogenic activity of toxaphene and isolated T2 and T12 congeners /
Toxaphene is the most abundant persistent organic pollutant in the Arctic and in the Great Lakes. Toxaphene technical mixture (Tox) applied as a pesticide consists of over 800 congeners. Through processes of environmental degradation, selected metabolism, and bioaccumulation, 2 congeners are promine...
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ftcanadathes:oai:collectionscanada.gc.ca:QMM.21647 2023-05-15T15:06:21+02:00 The relative estrogenic activity of toxaphene and isolated T2 and T12 congeners / Stelzer, Andreas. Chan, Laurie (advisor) Master of Science (Department of Natural Resource Sciences.) 1998 application/pdf http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21647 en eng McGill University alephsysno: 001657767 proquestno: MQ50887 Theses scanned by UMI/ProQuest. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21647 All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. Toxaphene Estrogen Electronic Thesis or Dissertation 1998 ftcanadathes 2014-02-16T00:44:04Z Toxaphene is the most abundant persistent organic pollutant in the Arctic and in the Great Lakes. Toxaphene technical mixture (Tox) applied as a pesticide consists of over 800 congeners. Through processes of environmental degradation, selected metabolism, and bioaccumulation, 2 congeners are prominent in humans; 2-exo,3-endo,5-exo,6-endo,8,8,10,10-octachlorobornane (T2) and 2-exo,3-endo,5-exo,6-endo,8,8,9,10,10-nonachlorocamphene (T12). The MCF7-E3 human breast cancer cell model was used to screen for the estrogenic activities of Tox, T2, and T12. A concentration of 10muM was required by all 3 compounds to elicit an estrogenic response (a proliferative effect (PE) upon the cells). The congeners however, showed slightly different PEs from Tox. Both T2 and T12 had a lower PE than Tox, and T2 had a higher PE than T12. Results from binary combination studies showed that effects of Tox, T2, and T12 were additive. Tox, T2, and T12 had no significant effects on estrogen receptor and progesterone receptor levels. It was shown that the environmental prevalent congeners had lower estrogenic activities than Tox and there is no synergistic effect. Thesis Arctic Theses Canada/Thèses Canada (Library and Archives Canada) Arctic |
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Open Polar |
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Theses Canada/Thèses Canada (Library and Archives Canada) |
op_collection_id |
ftcanadathes |
language |
English |
topic |
Toxaphene Estrogen |
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Toxaphene Estrogen Stelzer, Andreas. The relative estrogenic activity of toxaphene and isolated T2 and T12 congeners / |
topic_facet |
Toxaphene Estrogen |
description |
Toxaphene is the most abundant persistent organic pollutant in the Arctic and in the Great Lakes. Toxaphene technical mixture (Tox) applied as a pesticide consists of over 800 congeners. Through processes of environmental degradation, selected metabolism, and bioaccumulation, 2 congeners are prominent in humans; 2-exo,3-endo,5-exo,6-endo,8,8,10,10-octachlorobornane (T2) and 2-exo,3-endo,5-exo,6-endo,8,8,9,10,10-nonachlorocamphene (T12). The MCF7-E3 human breast cancer cell model was used to screen for the estrogenic activities of Tox, T2, and T12. A concentration of 10muM was required by all 3 compounds to elicit an estrogenic response (a proliferative effect (PE) upon the cells). The congeners however, showed slightly different PEs from Tox. Both T2 and T12 had a lower PE than Tox, and T2 had a higher PE than T12. Results from binary combination studies showed that effects of Tox, T2, and T12 were additive. Tox, T2, and T12 had no significant effects on estrogen receptor and progesterone receptor levels. It was shown that the environmental prevalent congeners had lower estrogenic activities than Tox and there is no synergistic effect. |
author2 |
Chan, Laurie (advisor) |
format |
Thesis |
author |
Stelzer, Andreas. |
author_facet |
Stelzer, Andreas. |
author_sort |
Stelzer, Andreas. |
title |
The relative estrogenic activity of toxaphene and isolated T2 and T12 congeners / |
title_short |
The relative estrogenic activity of toxaphene and isolated T2 and T12 congeners / |
title_full |
The relative estrogenic activity of toxaphene and isolated T2 and T12 congeners / |
title_fullStr |
The relative estrogenic activity of toxaphene and isolated T2 and T12 congeners / |
title_full_unstemmed |
The relative estrogenic activity of toxaphene and isolated T2 and T12 congeners / |
title_sort |
relative estrogenic activity of toxaphene and isolated t2 and t12 congeners / |
publisher |
McGill University |
publishDate |
1998 |
url |
http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21647 |
op_coverage |
Master of Science (Department of Natural Resource Sciences.) |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
alephsysno: 001657767 proquestno: MQ50887 Theses scanned by UMI/ProQuest. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21647 |
op_rights |
All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
_version_ |
1766337979212627968 |