The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis
Age-related hearing impairment (ARHI) is the most common sensory disorder in older adults. We conducted a genome-wide association meta-analysis of 121,934 ARHI cases and 591,699 controls from Iceland and the UK. We identified 21 novel sequence variants, of which 13 are rare, under either additive or...
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ftcaltechauth:oai:authors.library.caltech.edu:9cx95-nz677 2024-09-09T19:47:56+00:00 The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis Ivarsdottir, Erna V. Holm, Hilma Benonisdottir, Stefania Olafsdottir, Thorhildur Sveinbjornsson, Gardar Thorleifsson, Gudmar Eggertsson, Hannes P. Halldorsson, Gisli H. Hjorleifsson, Kristjan E. Melsted, Páll Gylfason, Arnaldur Arnadottir, Gudny A. Oddsson, Asmundur Jensson, Brynjar O. Jonasdottir, Aslaug Jonasdottir, Adalbjorg Juliusdottir, Thorhildur Stefansdottir, Lilja Tragante, Vinicius Halldorsson, Bjarni V. Petersen, Hannes Thorgeirsson, Gudmundur Thorsteinsdottir, Unnur Sulem, Patrick Hinriksdottir, Ingibjorg Jonsdottir, Ingileif Gudbjartsson, Daniel F. Stefansson, Kari 2021-06-09 https://doi.org/10.1038/s42003-021-02224-9 https://www.ncbi.nlm.nih.gov/pmc/PMC8190123 unknown Nature Publishing Group http://www.decode.com/summarydata https://github.com/lh3/bwa https://broadinstitute.github.io/picard/ http://samtools.github.io/ https://github.com/arq5x/bedtools2/ https://github.com/DecodeGenetics/graphtyper https://github.com/Ensembl/ensembl-vep https://doi.org/10.1038/s42003-021-02224-9 oai:authors.library.caltech.edu:9cx95-nz677 https://www.ncbi.nlm.nih.gov/pmc/PMC8190123 eprintid:109760 resolverid:CaltechAUTHORS:20210709-204110916 info:eu-repo/semantics/openAccess Other Communications Biology, 4, Art. No. 706, (2021-06-09) Ageing Genetic association study Genome-wide association studies info:eu-repo/semantics/article 2021 ftcaltechauth https://doi.org/10.1038/s42003-021-02224-9 2024-08-06T15:35:05Z Age-related hearing impairment (ARHI) is the most common sensory disorder in older adults. We conducted a genome-wide association meta-analysis of 121,934 ARHI cases and 591,699 controls from Iceland and the UK. We identified 21 novel sequence variants, of which 13 are rare, under either additive or recessive models. Of special interest are a missense variant in LOXHD1 (MAF = 1.96%) and a tandem duplication in FBF1 covering 4 exons (MAF = 0.22%) associating with ARHI (OR = 3.7 for homozygotes, P = 1.7 × 10â»Â²Â² and OR = 4.2 for heterozygotes, P = 5.7 × 10â»Â²â·, respectively). We constructed an ARHI genetic risk score (GRS) using common variants and showed that a common variant GRS can identify individuals at risk comparable to carriers of rare high penetrance variants. Furthermore, we found that ARHI and tinnitus share genetic causes. This study sheds a new light on the genetic architecture of ARHI, through several rare variants in both Mendelian deafness genes and genes not previously linked to hearing. © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Received 06 August 2020; Accepted 17 May 2021; Published 09 June 2021. We would like to thank all study participants for their ... Article in Journal/Newspaper Iceland Caltech Authors (California Institute of Technology) Communications Biology 4 1 |
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Caltech Authors (California Institute of Technology) |
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Ageing Genetic association study Genome-wide association studies |
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Ageing Genetic association study Genome-wide association studies Ivarsdottir, Erna V. Holm, Hilma Benonisdottir, Stefania Olafsdottir, Thorhildur Sveinbjornsson, Gardar Thorleifsson, Gudmar Eggertsson, Hannes P. Halldorsson, Gisli H. Hjorleifsson, Kristjan E. Melsted, Páll Gylfason, Arnaldur Arnadottir, Gudny A. Oddsson, Asmundur Jensson, Brynjar O. Jonasdottir, Aslaug Jonasdottir, Adalbjorg Juliusdottir, Thorhildur Stefansdottir, Lilja Tragante, Vinicius Halldorsson, Bjarni V. Petersen, Hannes Thorgeirsson, Gudmundur Thorsteinsdottir, Unnur Sulem, Patrick Hinriksdottir, Ingibjorg Jonsdottir, Ingileif Gudbjartsson, Daniel F. Stefansson, Kari The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis |
topic_facet |
Ageing Genetic association study Genome-wide association studies |
description |
Age-related hearing impairment (ARHI) is the most common sensory disorder in older adults. We conducted a genome-wide association meta-analysis of 121,934 ARHI cases and 591,699 controls from Iceland and the UK. We identified 21 novel sequence variants, of which 13 are rare, under either additive or recessive models. Of special interest are a missense variant in LOXHD1 (MAF = 1.96%) and a tandem duplication in FBF1 covering 4 exons (MAF = 0.22%) associating with ARHI (OR = 3.7 for homozygotes, P = 1.7 × 10â»Â²Â² and OR = 4.2 for heterozygotes, P = 5.7 × 10â»Â²â·, respectively). We constructed an ARHI genetic risk score (GRS) using common variants and showed that a common variant GRS can identify individuals at risk comparable to carriers of rare high penetrance variants. Furthermore, we found that ARHI and tinnitus share genetic causes. This study sheds a new light on the genetic architecture of ARHI, through several rare variants in both Mendelian deafness genes and genes not previously linked to hearing. © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Received 06 August 2020; Accepted 17 May 2021; Published 09 June 2021. We would like to thank all study participants for their ... |
format |
Article in Journal/Newspaper |
author |
Ivarsdottir, Erna V. Holm, Hilma Benonisdottir, Stefania Olafsdottir, Thorhildur Sveinbjornsson, Gardar Thorleifsson, Gudmar Eggertsson, Hannes P. Halldorsson, Gisli H. Hjorleifsson, Kristjan E. Melsted, Páll Gylfason, Arnaldur Arnadottir, Gudny A. Oddsson, Asmundur Jensson, Brynjar O. Jonasdottir, Aslaug Jonasdottir, Adalbjorg Juliusdottir, Thorhildur Stefansdottir, Lilja Tragante, Vinicius Halldorsson, Bjarni V. Petersen, Hannes Thorgeirsson, Gudmundur Thorsteinsdottir, Unnur Sulem, Patrick Hinriksdottir, Ingibjorg Jonsdottir, Ingileif Gudbjartsson, Daniel F. Stefansson, Kari |
author_facet |
Ivarsdottir, Erna V. Holm, Hilma Benonisdottir, Stefania Olafsdottir, Thorhildur Sveinbjornsson, Gardar Thorleifsson, Gudmar Eggertsson, Hannes P. Halldorsson, Gisli H. Hjorleifsson, Kristjan E. Melsted, Páll Gylfason, Arnaldur Arnadottir, Gudny A. Oddsson, Asmundur Jensson, Brynjar O. Jonasdottir, Aslaug Jonasdottir, Adalbjorg Juliusdottir, Thorhildur Stefansdottir, Lilja Tragante, Vinicius Halldorsson, Bjarni V. Petersen, Hannes Thorgeirsson, Gudmundur Thorsteinsdottir, Unnur Sulem, Patrick Hinriksdottir, Ingibjorg Jonsdottir, Ingileif Gudbjartsson, Daniel F. Stefansson, Kari |
author_sort |
Ivarsdottir, Erna V. |
title |
The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis |
title_short |
The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis |
title_full |
The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis |
title_fullStr |
The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis |
title_full_unstemmed |
The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis |
title_sort |
genetic architecture of age-related hearing impairment revealed by genome-wide association analysis |
publisher |
Nature Publishing Group |
publishDate |
2021 |
url |
https://doi.org/10.1038/s42003-021-02224-9 https://www.ncbi.nlm.nih.gov/pmc/PMC8190123 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Communications Biology, 4, Art. No. 706, (2021-06-09) |
op_relation |
http://www.decode.com/summarydata https://github.com/lh3/bwa https://broadinstitute.github.io/picard/ http://samtools.github.io/ https://github.com/arq5x/bedtools2/ https://github.com/DecodeGenetics/graphtyper https://github.com/Ensembl/ensembl-vep https://doi.org/10.1038/s42003-021-02224-9 oai:authors.library.caltech.edu:9cx95-nz677 https://www.ncbi.nlm.nih.gov/pmc/PMC8190123 eprintid:109760 resolverid:CaltechAUTHORS:20210709-204110916 |
op_rights |
info:eu-repo/semantics/openAccess Other |
op_doi |
https://doi.org/10.1038/s42003-021-02224-9 |
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Communications Biology |
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1809917337036390400 |