Funneled angle landscapes for helical proteins
We use crystallographic data for four helical iron proteins (cytochrome c-b₅₆₂, cytochrome c′, sperm whale myoglobin, human cytoglobin) to calculate radial and angular signatures as each unfolds from the native state stepwise though four unfolded states. From these data we construct an angle phase d...
Published in: | Journal of Inorganic Biochemistry |
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ftcaltechauth:oai:authors.library.caltech.edu:103106 2023-05-15T18:26:42+02:00 Funneled angle landscapes for helical proteins Kozak, John J. Gray, Harry B. Garza-López, Roberto A. 2020-07 application/pdf application/msword https://authors.library.caltech.edu/103106/ https://authors.library.caltech.edu/103106/1/1-s2.0-S0162013420301197-main.pdf https://authors.library.caltech.edu/103106/9/nihms-1601242.pdf https://authors.library.caltech.edu/103106/5/1-s2.0-S0162013420301197-mmc1.docx https://resolver.caltech.edu/CaltechAUTHORS:20200511-125453032 en eng Elsevier https://authors.library.caltech.edu/103106/1/1-s2.0-S0162013420301197-main.pdf https://authors.library.caltech.edu/103106/9/nihms-1601242.pdf https://authors.library.caltech.edu/103106/5/1-s2.0-S0162013420301197-mmc1.docx Kozak, John J. and Gray, Harry B. and Garza-López, Roberto A. (2020) Funneled angle landscapes for helical proteins. Journal of Inorganic Biochemistry, 208 . Art. No. 111091. ISSN 0162-0134. PMCID PMC7453651. doi:10.1016/j.jinorgbio.2020.111091. https://resolver.caltech.edu/CaltechAUTHORS:20200511-125453032 <https://resolver.caltech.edu/CaltechAUTHORS:20200511-125453032> other Article PeerReviewed 2020 ftcaltechauth https://doi.org/10.1016/j.jinorgbio.2020.111091 2022-02-17T18:46:06Z We use crystallographic data for four helical iron proteins (cytochrome c-b₅₆₂, cytochrome c′, sperm whale myoglobin, human cytoglobin) to calculate radial and angular signatures as each unfolds from the native state stepwise though four unfolded states. From these data we construct an angle phase diagram to display the evolution of each protein from its native state; and, in turn, the phase diagram is used to construct a funneled angle landscape for comparison with the topography of its folding energy landscape. We quantify the departure of individual helical and turning regions from the areal, angular profile of corresponding regions of the native state. This procedure allows us to identify the similarities and differences among individual helical and turning regions in the early stages of unfolding of the four helical heme proteins. Article in Journal/Newspaper Sperm whale Caltech Authors (California Institute of Technology) Journal of Inorganic Biochemistry 208 111091 |
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Open Polar |
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Caltech Authors (California Institute of Technology) |
op_collection_id |
ftcaltechauth |
language |
English |
description |
We use crystallographic data for four helical iron proteins (cytochrome c-b₅₆₂, cytochrome c′, sperm whale myoglobin, human cytoglobin) to calculate radial and angular signatures as each unfolds from the native state stepwise though four unfolded states. From these data we construct an angle phase diagram to display the evolution of each protein from its native state; and, in turn, the phase diagram is used to construct a funneled angle landscape for comparison with the topography of its folding energy landscape. We quantify the departure of individual helical and turning regions from the areal, angular profile of corresponding regions of the native state. This procedure allows us to identify the similarities and differences among individual helical and turning regions in the early stages of unfolding of the four helical heme proteins. |
format |
Article in Journal/Newspaper |
author |
Kozak, John J. Gray, Harry B. Garza-López, Roberto A. |
spellingShingle |
Kozak, John J. Gray, Harry B. Garza-López, Roberto A. Funneled angle landscapes for helical proteins |
author_facet |
Kozak, John J. Gray, Harry B. Garza-López, Roberto A. |
author_sort |
Kozak, John J. |
title |
Funneled angle landscapes for helical proteins |
title_short |
Funneled angle landscapes for helical proteins |
title_full |
Funneled angle landscapes for helical proteins |
title_fullStr |
Funneled angle landscapes for helical proteins |
title_full_unstemmed |
Funneled angle landscapes for helical proteins |
title_sort |
funneled angle landscapes for helical proteins |
publisher |
Elsevier |
publishDate |
2020 |
url |
https://authors.library.caltech.edu/103106/ https://authors.library.caltech.edu/103106/1/1-s2.0-S0162013420301197-main.pdf https://authors.library.caltech.edu/103106/9/nihms-1601242.pdf https://authors.library.caltech.edu/103106/5/1-s2.0-S0162013420301197-mmc1.docx https://resolver.caltech.edu/CaltechAUTHORS:20200511-125453032 |
genre |
Sperm whale |
genre_facet |
Sperm whale |
op_relation |
https://authors.library.caltech.edu/103106/1/1-s2.0-S0162013420301197-main.pdf https://authors.library.caltech.edu/103106/9/nihms-1601242.pdf https://authors.library.caltech.edu/103106/5/1-s2.0-S0162013420301197-mmc1.docx Kozak, John J. and Gray, Harry B. and Garza-López, Roberto A. (2020) Funneled angle landscapes for helical proteins. Journal of Inorganic Biochemistry, 208 . Art. No. 111091. ISSN 0162-0134. PMCID PMC7453651. doi:10.1016/j.jinorgbio.2020.111091. https://resolver.caltech.edu/CaltechAUTHORS:20200511-125453032 <https://resolver.caltech.edu/CaltechAUTHORS:20200511-125453032> |
op_rights |
other |
op_doi |
https://doi.org/10.1016/j.jinorgbio.2020.111091 |
container_title |
Journal of Inorganic Biochemistry |
container_volume |
208 |
container_start_page |
111091 |
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1766208678374932480 |