Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus)
In this study we investigated the hepatotoxic effect of DNOC in rats, using biochemical serum parameters as indicators of liver disease. Experimental groups were injected intraperitoneally with 2.8 mg/kg DNOC. While an increase was determined in LDH activities for all periods, an increase was determ...
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Online Access: | http://hdl.handle.net/11452/29267 http://www.doiserbia.nb.rs/img/doi/0567-8315/2007/0567-83150706497D.pdf https://doi.org/10.2298/AVB0706497D |
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ftbursauludaguni:oai:localhost:11452/29267 2023-05-15T18:05:16+02:00 Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus) Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü. orcid:0000-0002-6729-7908 Dere, Egemen Arı, Ferda Özdikicioğlu Tosunoğlu, Hakan AAH-5068-2021 AAG-7012-2021 6603627015 6504081459 23478447500 2007 application/pdf http://hdl.handle.net/11452/29267 http://www.doiserbia.nb.rs/img/doi/0567-8315/2007/0567-83150706497D.pdf https://doi.org/10.2298/AVB0706497D en eng Sciendo Makale - Uluslararası Hakemli Dergi Acta Veterinaria-Beograd Dere, E. vd. (2007). "Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus)". Acta Veterinaria-Beograd, 57(5-6), 497-507. 0567-8315 1820-7448 http://www.doiserbia.nb.rs/img/doi/0567-8315/2007/0567-83150706497D.pdf https://doi.org/10.2298/AVB0706497D http://hdl.handle.net/11452/29267 000251981100011 2-s2.0-38549130149 497 507 57 5-6 info:eu-repo/semantics/openAccess Atıf Gayri Ticari Türetilemez 4.0 Uluslararası http://creativecommons.org/licenses/by-nc-nd/4.0/ CC-BY-NC-ND ALP Rattus Rattus norvegicus ALT AST DNOC LDH Rat Veterinary sciences Cyprinus-carpio L Liver Pesticides Exposure Benzene Enzymes Tissues Heptachlor Persistent Organic Pollutants Photocatalytic Activity Article 2007 ftbursauludaguni https://doi.org/10.2298/AVB0706497D 2023-01-05T17:50:56Z In this study we investigated the hepatotoxic effect of DNOC in rats, using biochemical serum parameters as indicators of liver disease. Experimental groups were injected intraperitoneally with 2.8 mg/kg DNOC. While an increase was determined in LDH activities for all periods, an increase was determined for urea values only up to 16 hours. In general, increased AST and ALP activities were recorded up to the 8(th) hour. Thereof, at later periods inhibition was observed. Inhibition was observed in female rats, while ALT activation was observed in male rats. Amylase activity inhibition was observed in both groups. Increased values were observed for cholesterol and HDL at the initial hours. No significant changes were observed in triglyceride levels. As a result, it has been observed that DNOC caused changes in serum enzyme activities and in biochemical parameters in female and male rats. Article in Journal/Newspaper Rattus rattus Açık Erişim@BUU (Bursa Uludağ Üniversitesi) Acta veterinaria 57 5-6 497 507 |
institution |
Open Polar |
collection |
Açık Erişim@BUU (Bursa Uludağ Üniversitesi) |
op_collection_id |
ftbursauludaguni |
language |
English |
topic |
ALP Rattus Rattus norvegicus ALT AST DNOC LDH Rat Veterinary sciences Cyprinus-carpio L Liver Pesticides Exposure Benzene Enzymes Tissues Heptachlor Persistent Organic Pollutants Photocatalytic Activity |
spellingShingle |
ALP Rattus Rattus norvegicus ALT AST DNOC LDH Rat Veterinary sciences Cyprinus-carpio L Liver Pesticides Exposure Benzene Enzymes Tissues Heptachlor Persistent Organic Pollutants Photocatalytic Activity Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus) |
topic_facet |
ALP Rattus Rattus norvegicus ALT AST DNOC LDH Rat Veterinary sciences Cyprinus-carpio L Liver Pesticides Exposure Benzene Enzymes Tissues Heptachlor Persistent Organic Pollutants Photocatalytic Activity |
description |
In this study we investigated the hepatotoxic effect of DNOC in rats, using biochemical serum parameters as indicators of liver disease. Experimental groups were injected intraperitoneally with 2.8 mg/kg DNOC. While an increase was determined in LDH activities for all periods, an increase was determined for urea values only up to 16 hours. In general, increased AST and ALP activities were recorded up to the 8(th) hour. Thereof, at later periods inhibition was observed. Inhibition was observed in female rats, while ALT activation was observed in male rats. Amylase activity inhibition was observed in both groups. Increased values were observed for cholesterol and HDL at the initial hours. No significant changes were observed in triglyceride levels. As a result, it has been observed that DNOC caused changes in serum enzyme activities and in biochemical parameters in female and male rats. |
author2 |
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü. orcid:0000-0002-6729-7908 Dere, Egemen Arı, Ferda Özdikicioğlu Tosunoğlu, Hakan AAH-5068-2021 AAG-7012-2021 6603627015 6504081459 23478447500 |
format |
Article in Journal/Newspaper |
title |
Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus) |
title_short |
Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus) |
title_full |
Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus) |
title_fullStr |
Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus) |
title_full_unstemmed |
Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus) |
title_sort |
hepatotoxicity of dinitro-o-cresol in rats (rattus norvegicus) |
publisher |
Sciendo |
publishDate |
2007 |
url |
http://hdl.handle.net/11452/29267 http://www.doiserbia.nb.rs/img/doi/0567-8315/2007/0567-83150706497D.pdf https://doi.org/10.2298/AVB0706497D |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
Makale - Uluslararası Hakemli Dergi Acta Veterinaria-Beograd Dere, E. vd. (2007). "Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus)". Acta Veterinaria-Beograd, 57(5-6), 497-507. 0567-8315 1820-7448 http://www.doiserbia.nb.rs/img/doi/0567-8315/2007/0567-83150706497D.pdf https://doi.org/10.2298/AVB0706497D http://hdl.handle.net/11452/29267 000251981100011 2-s2.0-38549130149 497 507 57 5-6 |
op_rights |
info:eu-repo/semantics/openAccess Atıf Gayri Ticari Türetilemez 4.0 Uluslararası http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.2298/AVB0706497D |
container_title |
Acta veterinaria |
container_volume |
57 |
container_issue |
5-6 |
container_start_page |
497 |
op_container_end_page |
507 |
_version_ |
1766176738804498432 |