Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats
This study was designed to investigate the effects of Ulva rigida, one of the green algae, on the lipid profile and oxidative-antioxidative systems in streptozotocin-induced diabetic rats. Forty Wistar rats randomly divided into four groups: control (C), control + U. rigida extract (C + URE), diabet...
Published in: | Cell Biochemistry and Function |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Wiley
2011
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Online Access: | http://hdl.handle.net/11452/23804 https://doi.org/10.1002/cbf.1729 https://pubmed.ncbi.nlm.nih.gov/21370246/ |
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ftbursauludaguni:oai:acikerisim.uludag.edu.tr:11452/23804 2024-09-15T18:32:07+00:00 Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. orcid:0000-0002-2593-7196 orcid:0000-0002-4177-3478 orcid:0000-0001-6225-774X Taş, Sibel Çelikler, Serap Ziyanok, Sedef Ayvalık Sarandöl, Emre Dirican, Melahat ABE-6873-2020 ABE-1716-2020 AAG-6985-2021 AAH-2767-2021 7004343411 8234554800 15128398000 55943324800 6601919847 2011-03 http://hdl.handle.net/11452/23804 https://doi.org/10.1002/cbf.1729 https://pubmed.ncbi.nlm.nih.gov/21370246/ en eng Wiley Makale - Uluslararası Hakemli Dergi Cell Biochemistry and Function Taş, S. vd. (2011). "Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats". Cell Biochemistry and Function, 29(2), 108-113. 0263-6484 https://doi.org/10.1002/cbf.1729 https://pubmed.ncbi.nlm.nih.gov/21370246/ http://hdl.handle.net/11452/23804 000288079400005 2-s2.0-79952217192 108 113 29 2 21370246 info:eu-repo/semantics/closedAccess Biochemistry & molecular biology Cell biology Ulva rigida Diabetes Oxidative stress Antioxidant status Hyperlipidemia Serum paraoxonase activity Vanadyl sulfate Mellitus Antioxidant Extract Mice Atherosclerosis Aminoguanidine Hyperglycemia Complications Chlorophyta Rattus Rattus norvegicus Animals Blood glucose Carbohydrate metabolism Diabetes mellitus experimental Disease models animal Humans Hyperlipidemias Male Malondialdehyde Plant preparations Random allocation Rats wistar Ulva Aryldialkylphosphatase Arylesterase Human PON1 Protein Algal extract Antidiabetic agent Drinking water Glutathione peroxidase Article 2011 ftbursauludaguni https://doi.org/10.1002/cbf.1729 2024-07-31T03:14:16Z This study was designed to investigate the effects of Ulva rigida, one of the green algae, on the lipid profile and oxidative-antioxidative systems in streptozotocin-induced diabetic rats. Forty Wistar rats randomly divided into four groups: control (C), control + U. rigida extract (C + URE), diabetes (D) and diabetes + U. rigida extract (D + URE). U. rigida (2%) was administered in drinking water for 5 weeks after the induction of diabetes. U. rigida reduced the blood glucose, serum total cholesterol, triglyceride levels and plasma and tissue malondialdehyde (MDA) levels in the D + URE group. Insulin levels were significantly higher in the D + URE than those of the D group. Serum total cholesterol and tissue MDA levels were reduced in the C + URE group. Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities were higher in the D and C + URE groups compared with the C group. Paraoxonase and arylesterase activities were lower in the D group while U. rigida increased paraoxonase activities in C + URE and D + URE groups. This is the first study which showed U. rigida has antidiabetic and antihyperlipidemic effects and improves oxidative stress in diabetic rats. We conclude that U. rigida might have a potential use as a protective and/or therapeutic agent in diabetes mellitus. Article in Journal/Newspaper Rattus rattus Açık Erişim@BUU (Bursa Uludağ Üniversitesi) Cell Biochemistry and Function 29 2 108 113 |
institution |
Open Polar |
collection |
Açık Erişim@BUU (Bursa Uludağ Üniversitesi) |
op_collection_id |
ftbursauludaguni |
language |
English |
topic |
Biochemistry & molecular biology Cell biology Ulva rigida Diabetes Oxidative stress Antioxidant status Hyperlipidemia Serum paraoxonase activity Vanadyl sulfate Mellitus Antioxidant Extract Mice Atherosclerosis Aminoguanidine Hyperglycemia Complications Chlorophyta Rattus Rattus norvegicus Animals Blood glucose Carbohydrate metabolism Diabetes mellitus experimental Disease models animal Humans Hyperlipidemias Male Malondialdehyde Plant preparations Random allocation Rats wistar Ulva Aryldialkylphosphatase Arylesterase Human PON1 Protein Algal extract Antidiabetic agent Drinking water Glutathione peroxidase |
spellingShingle |
Biochemistry & molecular biology Cell biology Ulva rigida Diabetes Oxidative stress Antioxidant status Hyperlipidemia Serum paraoxonase activity Vanadyl sulfate Mellitus Antioxidant Extract Mice Atherosclerosis Aminoguanidine Hyperglycemia Complications Chlorophyta Rattus Rattus norvegicus Animals Blood glucose Carbohydrate metabolism Diabetes mellitus experimental Disease models animal Humans Hyperlipidemias Male Malondialdehyde Plant preparations Random allocation Rats wistar Ulva Aryldialkylphosphatase Arylesterase Human PON1 Protein Algal extract Antidiabetic agent Drinking water Glutathione peroxidase Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats |
topic_facet |
Biochemistry & molecular biology Cell biology Ulva rigida Diabetes Oxidative stress Antioxidant status Hyperlipidemia Serum paraoxonase activity Vanadyl sulfate Mellitus Antioxidant Extract Mice Atherosclerosis Aminoguanidine Hyperglycemia Complications Chlorophyta Rattus Rattus norvegicus Animals Blood glucose Carbohydrate metabolism Diabetes mellitus experimental Disease models animal Humans Hyperlipidemias Male Malondialdehyde Plant preparations Random allocation Rats wistar Ulva Aryldialkylphosphatase Arylesterase Human PON1 Protein Algal extract Antidiabetic agent Drinking water Glutathione peroxidase |
description |
This study was designed to investigate the effects of Ulva rigida, one of the green algae, on the lipid profile and oxidative-antioxidative systems in streptozotocin-induced diabetic rats. Forty Wistar rats randomly divided into four groups: control (C), control + U. rigida extract (C + URE), diabetes (D) and diabetes + U. rigida extract (D + URE). U. rigida (2%) was administered in drinking water for 5 weeks after the induction of diabetes. U. rigida reduced the blood glucose, serum total cholesterol, triglyceride levels and plasma and tissue malondialdehyde (MDA) levels in the D + URE group. Insulin levels were significantly higher in the D + URE than those of the D group. Serum total cholesterol and tissue MDA levels were reduced in the C + URE group. Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities were higher in the D and C + URE groups compared with the C group. Paraoxonase and arylesterase activities were lower in the D group while U. rigida increased paraoxonase activities in C + URE and D + URE groups. This is the first study which showed U. rigida has antidiabetic and antihyperlipidemic effects and improves oxidative stress in diabetic rats. We conclude that U. rigida might have a potential use as a protective and/or therapeutic agent in diabetes mellitus. |
author2 |
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı. orcid:0000-0002-2593-7196 orcid:0000-0002-4177-3478 orcid:0000-0001-6225-774X Taş, Sibel Çelikler, Serap Ziyanok, Sedef Ayvalık Sarandöl, Emre Dirican, Melahat ABE-6873-2020 ABE-1716-2020 AAG-6985-2021 AAH-2767-2021 7004343411 8234554800 15128398000 55943324800 6601919847 |
format |
Article in Journal/Newspaper |
title |
Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats |
title_short |
Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats |
title_full |
Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats |
title_fullStr |
Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats |
title_full_unstemmed |
Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats |
title_sort |
ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats |
publisher |
Wiley |
publishDate |
2011 |
url |
http://hdl.handle.net/11452/23804 https://doi.org/10.1002/cbf.1729 https://pubmed.ncbi.nlm.nih.gov/21370246/ |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
Makale - Uluslararası Hakemli Dergi Cell Biochemistry and Function Taş, S. vd. (2011). "Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats". Cell Biochemistry and Function, 29(2), 108-113. 0263-6484 https://doi.org/10.1002/cbf.1729 https://pubmed.ncbi.nlm.nih.gov/21370246/ http://hdl.handle.net/11452/23804 000288079400005 2-s2.0-79952217192 108 113 29 2 21370246 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1002/cbf.1729 |
container_title |
Cell Biochemistry and Function |
container_volume |
29 |
container_issue |
2 |
container_start_page |
108 |
op_container_end_page |
113 |
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1810473874321571840 |