Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats

• Published in: Cell Biochemistry and Function
• Other Authors: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı., orcid:0000-0002-2593-7196, orcid:0000-0002-4177-3478, orcid:0000-0001-6225-774X, Taş, Sibel, Çelikler, Serap, Ziyanok, Sedef Ayvalık, Sarandöl, Emre, Dirican, Melahat, ABE-6873-2020, ABE-1716-2020, AAG-6985-2021, AAH-2767-2021, 7004343411, 8234554800, 15128398000, 55943324800, 6601919847
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wiley 2011
• Subjects: Biochemistry & molecular biology; Cell biology; Ulva rigida; Diabetes; Oxidative stress; Antioxidant status; Hyperlipidemia; Serum paraoxonase activity; Vanadyl sulfate; Mellitus; Antioxidant; Extract; Mice; Atherosclerosis; Aminoguanidine; Hyperglycemia; Complications; Chlorophyta; Rattus; Rattus norvegicus; Animals; Blood glucose; Carbohydrate metabolism; Diabetes mellitus; experimental; Disease models; animal; Humans; Hyperlipidemias; Male; Malondialdehyde; Plant preparations; Random allocation; Rats; wistar; Ulva; Aryldialkylphosphatase; Arylesterase; Human PON1 Protein; Algal extract; Antidiabetic agent; Drinking water; Glutathione peroxidase; Rattus rattus
• Online Access: http://hdl.handle.net/11452/23804; https://doi.org/10.1002/cbf.1729; https://pubmed.ncbi.nlm.nih.gov/21370246/

This study was designed to investigate the effects of Ulva rigida, one of the green algae, on the lipid profile and oxidative-antioxidative systems in streptozotocin-induced diabetic rats. Forty Wistar rats randomly divided into four groups: control (C), control + U. rigida extract (C + URE), diabetes (D) and diabetes + U. rigida extract (D + URE). U. rigida (2%) was administered in drinking water for 5 weeks after the induction of diabetes. U. rigida reduced the blood glucose, serum total cholesterol, triglyceride levels and plasma and tissue malondialdehyde (MDA) levels in the D + URE group. Insulin levels were significantly higher in the D + URE than those of the D group. Serum total cholesterol and tissue MDA levels were reduced in the C + URE group. Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities were higher in the D and C + URE groups compared with the C group. Paraoxonase and arylesterase activities were lower in the D group while U. rigida increased paraoxonase activities in C + URE and D + URE groups. This is the first study which showed U. rigida has antidiabetic and antihyperlipidemic effects and improves oxidative stress in diabetic rats. We conclude that U. rigida might have a potential use as a protective and/or therapeutic agent in diabetes mellitus.