Absence or Reduction of Carbonic Anhydrase II in the Red Cells of the Beluga Whale and Llama: Implications for Adaptation to Hypoxia
Carbonic anhydrase (CA) expression was examined in the red cells of two mammals that have adapted to low oxygen stress: the llama, which has adapted to high altitudes, and the beluga (or white) whale, which routinely dives for extended periods. Immunodiffusion analyses of their Hb-free hemolysates a...
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ftbryantuniv:oai:digitalcommons.bryant.edu:sci_jou-1010 2023-05-15T15:41:30+02:00 Absence or Reduction of Carbonic Anhydrase II in the Red Cells of the Beluga Whale and Llama: Implications for Adaptation to Hypoxia Yang, Hong Hewett-Emmett, David Tashian, Richard E. 2000-08-01T07:00:00Z https://digitalcommons.bryant.edu/sci_jou/11 English eng Bryant Digital Repository https://digitalcommons.bryant.edu/sci_jou/11 Science and Technology Faculty Journal Articles hypoxia;red cell carbonic anhydrases;beluga whale;llama text 2000 ftbryantuniv 2022-06-06T07:28:58Z Carbonic anhydrase (CA) expression was examined in the red cells of two mammals that have adapted to low oxygen stress: the llama, which has adapted to high altitudes, and the beluga (or white) whale, which routinely dives for extended periods. Immunodiffusion analyses of their Hb-free hemolysates and partial amino acid sequencing of their HPLC-separated nonheme proteins indicate that the low-activity CA I isozyme is the major nonheme protein in erythrocytes of both the beluga whale and the llama. The high-activity CA II isozyme was not detected in the whale red cells but was present at low levels in erythrocytes of the llama. These results suggest that the absence or decrease in the expression of the high-activity CA II isozyme may be advantageous under hypoxic conditions. Text Beluga Beluga whale Beluga* White whale DigitalCommons@Bryant University |
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Open Polar |
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DigitalCommons@Bryant University |
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ftbryantuniv |
language |
English |
topic |
hypoxia;red cell carbonic anhydrases;beluga whale;llama |
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hypoxia;red cell carbonic anhydrases;beluga whale;llama Yang, Hong Hewett-Emmett, David Tashian, Richard E. Absence or Reduction of Carbonic Anhydrase II in the Red Cells of the Beluga Whale and Llama: Implications for Adaptation to Hypoxia |
topic_facet |
hypoxia;red cell carbonic anhydrases;beluga whale;llama |
description |
Carbonic anhydrase (CA) expression was examined in the red cells of two mammals that have adapted to low oxygen stress: the llama, which has adapted to high altitudes, and the beluga (or white) whale, which routinely dives for extended periods. Immunodiffusion analyses of their Hb-free hemolysates and partial amino acid sequencing of their HPLC-separated nonheme proteins indicate that the low-activity CA I isozyme is the major nonheme protein in erythrocytes of both the beluga whale and the llama. The high-activity CA II isozyme was not detected in the whale red cells but was present at low levels in erythrocytes of the llama. These results suggest that the absence or decrease in the expression of the high-activity CA II isozyme may be advantageous under hypoxic conditions. |
format |
Text |
author |
Yang, Hong Hewett-Emmett, David Tashian, Richard E. |
author_facet |
Yang, Hong Hewett-Emmett, David Tashian, Richard E. |
author_sort |
Yang, Hong |
title |
Absence or Reduction of Carbonic Anhydrase II in the Red Cells of the Beluga Whale and Llama: Implications for Adaptation to Hypoxia |
title_short |
Absence or Reduction of Carbonic Anhydrase II in the Red Cells of the Beluga Whale and Llama: Implications for Adaptation to Hypoxia |
title_full |
Absence or Reduction of Carbonic Anhydrase II in the Red Cells of the Beluga Whale and Llama: Implications for Adaptation to Hypoxia |
title_fullStr |
Absence or Reduction of Carbonic Anhydrase II in the Red Cells of the Beluga Whale and Llama: Implications for Adaptation to Hypoxia |
title_full_unstemmed |
Absence or Reduction of Carbonic Anhydrase II in the Red Cells of the Beluga Whale and Llama: Implications for Adaptation to Hypoxia |
title_sort |
absence or reduction of carbonic anhydrase ii in the red cells of the beluga whale and llama: implications for adaptation to hypoxia |
publisher |
Bryant Digital Repository |
publishDate |
2000 |
url |
https://digitalcommons.bryant.edu/sci_jou/11 |
genre |
Beluga Beluga whale Beluga* White whale |
genre_facet |
Beluga Beluga whale Beluga* White whale |
op_source |
Science and Technology Faculty Journal Articles |
op_relation |
https://digitalcommons.bryant.edu/sci_jou/11 |
_version_ |
1766374392565071872 |