Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966
Objective: Life stress resulting from early-life experiences and domestic stress is linked with shorter leukocyte telomere length (LTL), but evidence on employment-related stress is scarce. We explored whether unemployment in early adulthood is associated with shorter LTL, a potential biomarker of p...
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Public Library of Science
2013
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ftbruneluniv:oai:bura.brunel.ac.uk:2438/14653 2023-05-15T17:42:20+02:00 Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966 Ala-Mursula, L Buxton, JL Ek, E Koiranen, M Taanila, A Blakemore, AIF Jarvelin, M-R 2013 ? - ? (8) http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327313100074&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 http://bura.brunel.ac.uk/handle/2438/14653 https://doi.org/10.1371/journal.pone.0080094 English en eng Public Library of Science PLOS ONE PLOS ONE, 8 (11): (2013) http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327313100074&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 UNSP e80094 1932-6203 http://bura.brunel.ac.uk/handle/2438/14653 http://dx.doi.org/10.1371/journal.pone.0080094 Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics LIFE STRESS FOLLOW-UP LENGTH WOMEN DISEASE HEALTH EPIDEMIOLOGY EMPLOYMENT BIOMARKER CANCER Article 2013 ftbruneluniv https://doi.org/10.1371/journal.pone.0080094 2021-08-08T08:36:43Z Objective: Life stress resulting from early-life experiences and domestic stress is linked with shorter leukocyte telomere length (LTL), but evidence on employment-related stress is scarce. We explored whether unemployment in early adulthood is associated with shorter LTL, a potential biomarker of premature aging. Methods: We used data from 5620 men and women belonging to the Northern Finland Birth Cohort 1966. Individually registered unemployment days in 1995–97 were compared with data on biological, behavioral and socioeconomic health predictors and existing medical conditions obtained by surveys and clinical examinations at follow-up in 1997–98. Mean LTL at follow-up was measured by multiplex quantitative real-time PCR. We calculated odds ratios and their 95% confidence intervals (CI) of belonging to the sex-stratified shortest decile of standardized relative mean LTL according to the categories of: 0, ,260, ,500 and over 500 unemployment days, representing 0, ,1, ,2 and over 2 calendar years.Results: Among men, unemployment exceeding 500 days during three years was associated with having shorter LTL at follow-up, compared to being continuously employed. The corresponding odds ratio was 2.61 (95% CI 1.16 to 5.85) in the fully adjusted model. Such an association was not found among women in this study. Conclusions: Long-term unemployment in early adulthood is associated with shorter LTL among men. Citation: Article in Journal/Newspaper Northern Finland Brunel University London: Brunel University Research Archive (BURA) PLoS ONE 8 11 e80094 |
institution |
Open Polar |
collection |
Brunel University London: Brunel University Research Archive (BURA) |
op_collection_id |
ftbruneluniv |
language |
English |
topic |
Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics LIFE STRESS FOLLOW-UP LENGTH WOMEN DISEASE HEALTH EPIDEMIOLOGY EMPLOYMENT BIOMARKER CANCER |
spellingShingle |
Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics LIFE STRESS FOLLOW-UP LENGTH WOMEN DISEASE HEALTH EPIDEMIOLOGY EMPLOYMENT BIOMARKER CANCER Ala-Mursula, L Buxton, JL Ek, E Koiranen, M Taanila, A Blakemore, AIF Jarvelin, M-R Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966 |
topic_facet |
Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics LIFE STRESS FOLLOW-UP LENGTH WOMEN DISEASE HEALTH EPIDEMIOLOGY EMPLOYMENT BIOMARKER CANCER |
description |
Objective: Life stress resulting from early-life experiences and domestic stress is linked with shorter leukocyte telomere length (LTL), but evidence on employment-related stress is scarce. We explored whether unemployment in early adulthood is associated with shorter LTL, a potential biomarker of premature aging. Methods: We used data from 5620 men and women belonging to the Northern Finland Birth Cohort 1966. Individually registered unemployment days in 1995–97 were compared with data on biological, behavioral and socioeconomic health predictors and existing medical conditions obtained by surveys and clinical examinations at follow-up in 1997–98. Mean LTL at follow-up was measured by multiplex quantitative real-time PCR. We calculated odds ratios and their 95% confidence intervals (CI) of belonging to the sex-stratified shortest decile of standardized relative mean LTL according to the categories of: 0, ,260, ,500 and over 500 unemployment days, representing 0, ,1, ,2 and over 2 calendar years.Results: Among men, unemployment exceeding 500 days during three years was associated with having shorter LTL at follow-up, compared to being continuously employed. The corresponding odds ratio was 2.61 (95% CI 1.16 to 5.85) in the fully adjusted model. Such an association was not found among women in this study. Conclusions: Long-term unemployment in early adulthood is associated with shorter LTL among men. Citation: |
format |
Article in Journal/Newspaper |
author |
Ala-Mursula, L Buxton, JL Ek, E Koiranen, M Taanila, A Blakemore, AIF Jarvelin, M-R |
author_facet |
Ala-Mursula, L Buxton, JL Ek, E Koiranen, M Taanila, A Blakemore, AIF Jarvelin, M-R |
author_sort |
Ala-Mursula, L |
title |
Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966 |
title_short |
Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966 |
title_full |
Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966 |
title_fullStr |
Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966 |
title_full_unstemmed |
Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966 |
title_sort |
long-term unemployment is associated with short telomeres in 31-year-old men: an observational study in the northern finland birth cohort 1966 |
publisher |
Public Library of Science |
publishDate |
2013 |
url |
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327313100074&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 http://bura.brunel.ac.uk/handle/2438/14653 https://doi.org/10.1371/journal.pone.0080094 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
PLOS ONE PLOS ONE, 8 (11): (2013) http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000327313100074&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=f12c8c83318cf2733e615e54d9ed7ad5 UNSP e80094 1932-6203 http://bura.brunel.ac.uk/handle/2438/14653 http://dx.doi.org/10.1371/journal.pone.0080094 |
op_doi |
https://doi.org/10.1371/journal.pone.0080094 |
container_title |
PLoS ONE |
container_volume |
8 |
container_issue |
11 |
container_start_page |
e80094 |
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1766144177917132800 |