Association between Occupation and Knee and Hip Replacement Due to Osteoarthritis: A Case-Control Study
INTRODUCTION. The objective of this study was to examine the association between occupation and osteoarthritis (OA) leading to total knee (TKR) or hip (THR) joint replacement. METHODS. The following is the case-control study design. All patients still living in Iceland who had had a TKR or THR due t...
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ftbostonuniv:oai:open.bu.edu:2144/2872 2023-05-15T13:08:33+02:00 Association between Occupation and Knee and Hip Replacement Due to Osteoarthritis: A Case-Control Study Franklin, Jonas Ingvarsson, Thorvaldur Englund, Martin Lohmander, Stefan 2010-5-24 https://hdl.handle.net/2144/2872 https://doi.org/10.1186/ar3033 en eng BioMed Central Franklin, Jonas, Thorvaldur Ingvarsson, Martin Englund, Stefan Lohmander. "Association between occupation and knee and hip replacement due to osteoarthritis: a case-control study" Arthritis Research & Therapy 12(3):R102. (2010) 1478-6362 https://hdl.handle.net/2144/2872 doi:10.1186/ar3033 20497530 2911890 Copyright 2010 Franklin et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/2.0 CC-BY Article 2010 ftbostonuniv https://doi.org/10.1186/ar3033 2022-07-11T11:40:59Z INTRODUCTION. The objective of this study was to examine the association between occupation and osteoarthritis (OA) leading to total knee (TKR) or hip (THR) joint replacement. METHODS. The following is the case-control study design. All patients still living in Iceland who had had a TKR or THR due to OA as of the end of 2002 were invited to participate. First degree relatives of participating patients served as controls. N = 1,408 cases (832 women) and n = 1,082 controls (592 women), 60 years or older and who had adequately answered a questionnaire were analyzed. Occupations were classified according to international standards. Inheritance of occupations was calculated by using the Icelandic Genealogy Database. RESULTS. The age adjusted odds ratio (OR) for male farmers getting a TKR due to OA was 5.1 (95% confidence interval (CI) 2.1 to 12.4) and for a male farmer getting a THR due to OA the OR was 3.6 (95% CI 2.1 to 6.2). The OR for a fisherman getting a TKR was 3.3 (95% CI 1.3 to 8.4). No other occupations showed increased risk for men. For women there was no increased risk for any occupation. Farming and fishing were also the occupations that showed the greatest degree of inheritance. CONCLUSIONS. These results support an association in males between occupations with heavy physical load and both TKR and THR for OA. Scientific Foundation of Akureyri Central Hospital; Swedish Research Council (Medicine); Lund Medical Faculty and University Hospital; King Gustaf V 80-year Fund; Swedish Rheumatism Association; Kock Foundations Article in Journal/Newspaper Akureyri Akureyri Akureyri Iceland Boston University: OpenBU Akureyri Arthritis Research & Therapy 12 3 R102 |
institution |
Open Polar |
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Boston University: OpenBU |
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ftbostonuniv |
language |
English |
description |
INTRODUCTION. The objective of this study was to examine the association between occupation and osteoarthritis (OA) leading to total knee (TKR) or hip (THR) joint replacement. METHODS. The following is the case-control study design. All patients still living in Iceland who had had a TKR or THR due to OA as of the end of 2002 were invited to participate. First degree relatives of participating patients served as controls. N = 1,408 cases (832 women) and n = 1,082 controls (592 women), 60 years or older and who had adequately answered a questionnaire were analyzed. Occupations were classified according to international standards. Inheritance of occupations was calculated by using the Icelandic Genealogy Database. RESULTS. The age adjusted odds ratio (OR) for male farmers getting a TKR due to OA was 5.1 (95% confidence interval (CI) 2.1 to 12.4) and for a male farmer getting a THR due to OA the OR was 3.6 (95% CI 2.1 to 6.2). The OR for a fisherman getting a TKR was 3.3 (95% CI 1.3 to 8.4). No other occupations showed increased risk for men. For women there was no increased risk for any occupation. Farming and fishing were also the occupations that showed the greatest degree of inheritance. CONCLUSIONS. These results support an association in males between occupations with heavy physical load and both TKR and THR for OA. Scientific Foundation of Akureyri Central Hospital; Swedish Research Council (Medicine); Lund Medical Faculty and University Hospital; King Gustaf V 80-year Fund; Swedish Rheumatism Association; Kock Foundations |
format |
Article in Journal/Newspaper |
author |
Franklin, Jonas Ingvarsson, Thorvaldur Englund, Martin Lohmander, Stefan |
spellingShingle |
Franklin, Jonas Ingvarsson, Thorvaldur Englund, Martin Lohmander, Stefan Association between Occupation and Knee and Hip Replacement Due to Osteoarthritis: A Case-Control Study |
author_facet |
Franklin, Jonas Ingvarsson, Thorvaldur Englund, Martin Lohmander, Stefan |
author_sort |
Franklin, Jonas |
title |
Association between Occupation and Knee and Hip Replacement Due to Osteoarthritis: A Case-Control Study |
title_short |
Association between Occupation and Knee and Hip Replacement Due to Osteoarthritis: A Case-Control Study |
title_full |
Association between Occupation and Knee and Hip Replacement Due to Osteoarthritis: A Case-Control Study |
title_fullStr |
Association between Occupation and Knee and Hip Replacement Due to Osteoarthritis: A Case-Control Study |
title_full_unstemmed |
Association between Occupation and Knee and Hip Replacement Due to Osteoarthritis: A Case-Control Study |
title_sort |
association between occupation and knee and hip replacement due to osteoarthritis: a case-control study |
publisher |
BioMed Central |
publishDate |
2010 |
url |
https://hdl.handle.net/2144/2872 https://doi.org/10.1186/ar3033 |
geographic |
Akureyri |
geographic_facet |
Akureyri |
genre |
Akureyri Akureyri Akureyri Iceland |
genre_facet |
Akureyri Akureyri Akureyri Iceland |
op_relation |
Franklin, Jonas, Thorvaldur Ingvarsson, Martin Englund, Stefan Lohmander. "Association between occupation and knee and hip replacement due to osteoarthritis: a case-control study" Arthritis Research & Therapy 12(3):R102. (2010) 1478-6362 https://hdl.handle.net/2144/2872 doi:10.1186/ar3033 20497530 2911890 |
op_rights |
Copyright 2010 Franklin et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/2.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1186/ar3033 |
container_title |
Arthritis Research & Therapy |
container_volume |
12 |
container_issue |
3 |
container_start_page |
R102 |
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1766096808591753216 |