Risk factors, coronary artery disease and mortality in giant cell arteritis: a population-based study
Giant Cell arteritis (GCA) is a systemic inflammatory disease that affects arteries of medium- and large size. Symptoms of GCA such as headache and fever usually promptly improve with treatment of glucocorticoids. Apart from advanced age, female sex and Northern-European descent, risk factors for GC...
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ftbostonuniv:oai:open.bu.edu:2144/16296 2023-05-15T16:52:19+02:00 Risk factors, coronary artery disease and mortality in giant cell arteritis: a population-based study Tómasson, Gunnar 2016-04-08T20:43:13Z https://hdl.handle.net/2144/16296 en_US eng https://hdl.handle.net/2144/16296 Epidemiology Incidence Mortality Coronary heart disease Giant cell arteritis Thesis/Dissertation 2016 ftbostonuniv 2022-07-11T11:51:29Z Giant Cell arteritis (GCA) is a systemic inflammatory disease that affects arteries of medium- and large size. Symptoms of GCA such as headache and fever usually promptly improve with treatment of glucocorticoids. Apart from advanced age, female sex and Northern-European descent, risk factors for GCA are unknown. Most studies have found that life expectancy for patients with GCA is not reduced compared with the general population and studies on cardiovascular disease in GCA have provided conflicting results. Data for the studies of this thesis are drawn from the Reykjavik Study (RS) that is a general population-based cohort study with continuous surveillance for coronary heart disease and vital status. Subjects born in 1907–1934 and living in Reykjavik, Iceland or adjacent communities in 1966 were invited for study visit from 1967-1994. Information on cardiovascular risk factors were collected at study visit. Diagnosis of GCA for this study was based on re-examination of all temporal arteries biopsies (TAB) from members of the RS cohort; however, information was also obtained from the original pathology report. Of 19,360 subjects included in the RS, 194 developed GCA during the follow-up period. Body mass index was inversely associated with the occurrence of GCA. Among men, but not women, hypertension was associated and smoking inversely associated with the occurrence of GCA. Among women, but not men, GCA was associated with coronary heart disease. Subjects with GCA had approximately 50% increase in mortality risk compared with the general population. Increase mortality was mainly observed among GCA patients based on the diagnosis of re-examination of TAB; however, no such an association was found if diagnosis of GCA was made based on the original pathology report. Those subjects were likely not clinically diagnosed with GCA, signaling that treatment for GCA might be beneficial with respect to mortality risk. Thesis Iceland Boston University: OpenBU |
institution |
Open Polar |
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Boston University: OpenBU |
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ftbostonuniv |
language |
English |
topic |
Epidemiology Incidence Mortality Coronary heart disease Giant cell arteritis |
spellingShingle |
Epidemiology Incidence Mortality Coronary heart disease Giant cell arteritis Tómasson, Gunnar Risk factors, coronary artery disease and mortality in giant cell arteritis: a population-based study |
topic_facet |
Epidemiology Incidence Mortality Coronary heart disease Giant cell arteritis |
description |
Giant Cell arteritis (GCA) is a systemic inflammatory disease that affects arteries of medium- and large size. Symptoms of GCA such as headache and fever usually promptly improve with treatment of glucocorticoids. Apart from advanced age, female sex and Northern-European descent, risk factors for GCA are unknown. Most studies have found that life expectancy for patients with GCA is not reduced compared with the general population and studies on cardiovascular disease in GCA have provided conflicting results. Data for the studies of this thesis are drawn from the Reykjavik Study (RS) that is a general population-based cohort study with continuous surveillance for coronary heart disease and vital status. Subjects born in 1907–1934 and living in Reykjavik, Iceland or adjacent communities in 1966 were invited for study visit from 1967-1994. Information on cardiovascular risk factors were collected at study visit. Diagnosis of GCA for this study was based on re-examination of all temporal arteries biopsies (TAB) from members of the RS cohort; however, information was also obtained from the original pathology report. Of 19,360 subjects included in the RS, 194 developed GCA during the follow-up period. Body mass index was inversely associated with the occurrence of GCA. Among men, but not women, hypertension was associated and smoking inversely associated with the occurrence of GCA. Among women, but not men, GCA was associated with coronary heart disease. Subjects with GCA had approximately 50% increase in mortality risk compared with the general population. Increase mortality was mainly observed among GCA patients based on the diagnosis of re-examination of TAB; however, no such an association was found if diagnosis of GCA was made based on the original pathology report. Those subjects were likely not clinically diagnosed with GCA, signaling that treatment for GCA might be beneficial with respect to mortality risk. |
format |
Thesis |
author |
Tómasson, Gunnar |
author_facet |
Tómasson, Gunnar |
author_sort |
Tómasson, Gunnar |
title |
Risk factors, coronary artery disease and mortality in giant cell arteritis: a population-based study |
title_short |
Risk factors, coronary artery disease and mortality in giant cell arteritis: a population-based study |
title_full |
Risk factors, coronary artery disease and mortality in giant cell arteritis: a population-based study |
title_fullStr |
Risk factors, coronary artery disease and mortality in giant cell arteritis: a population-based study |
title_full_unstemmed |
Risk factors, coronary artery disease and mortality in giant cell arteritis: a population-based study |
title_sort |
risk factors, coronary artery disease and mortality in giant cell arteritis: a population-based study |
publishDate |
2016 |
url |
https://hdl.handle.net/2144/16296 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
https://hdl.handle.net/2144/16296 |
_version_ |
1766042462640406528 |