PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID, A LONG-ACTING CEPHALOSPORIN, IN AMERICAN FLAMINGOS (PHOENICOPTERUS RUBER)
Antibiotic usage is a vital component of veterinary medicine but the unique anatomy of some species can make administration difficult. The objective of this study was to determine the pharmacokinetic parameters of ceftiofur crystalline free acid (CCFA), a long-acting cephalosporin antibiotic, after...
Published in: | Journal of Zoo and Wildlife Medicine |
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American Association of Zoo Veterinarians
2016
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ftbioone:10.1638/2015-0278.1 2023-07-30T04:02:28+02:00 PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID, A LONG-ACTING CEPHALOSPORIN, IN AMERICAN FLAMINGOS (PHOENICOPTERUS RUBER) Jennifer J. Kilburn Sherry K. Cox Kay A. Backues Jennifer J. Kilburn Sherry K. Cox Kay A. Backues world 2016-06-01 text/HTML https://doi.org/10.1638/2015-0278.1 en eng American Association of Zoo Veterinarians doi:10.1638/2015-0278.1 All rights reserved. https://doi.org/10.1638/2015-0278.1 Text 2016 ftbioone https://doi.org/10.1638/2015-0278.1 2023-07-09T10:51:37Z Antibiotic usage is a vital component of veterinary medicine but the unique anatomy of some species can make administration difficult. The objective of this study was to determine the pharmacokinetic parameters of ceftiofur crystalline free acid (CCFA), a long-acting cephalosporin antibiotic, after parenteral administration in American flamingos (Phoenicopterus ruber). A dose of 10 mg/kg of CCFA was administered intramuscularly to 11 birds and blood was collected at various time points from 0 to 192 hr. Pharmacokinetic parameters for ceftiofur equivalents were determined and reached levels above minimum inhibitory concentrations of various bacterial organisms in other avian species through 96 hr in 9/11 birds. Based on these findings and comparison to other avian studies, ceftiofur crystalline free acid appears to be a long-acting antibiotic option for American flamingos. Administration of this antibiotic should be utilized in conjunction with culture and sensitivity of suspected pathogens. Text Avian Studies BioOne Online Journals Journal of Zoo and Wildlife Medicine 47 2 457 462 |
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English |
description |
Antibiotic usage is a vital component of veterinary medicine but the unique anatomy of some species can make administration difficult. The objective of this study was to determine the pharmacokinetic parameters of ceftiofur crystalline free acid (CCFA), a long-acting cephalosporin antibiotic, after parenteral administration in American flamingos (Phoenicopterus ruber). A dose of 10 mg/kg of CCFA was administered intramuscularly to 11 birds and blood was collected at various time points from 0 to 192 hr. Pharmacokinetic parameters for ceftiofur equivalents were determined and reached levels above minimum inhibitory concentrations of various bacterial organisms in other avian species through 96 hr in 9/11 birds. Based on these findings and comparison to other avian studies, ceftiofur crystalline free acid appears to be a long-acting antibiotic option for American flamingos. Administration of this antibiotic should be utilized in conjunction with culture and sensitivity of suspected pathogens. |
author2 |
Jennifer J. Kilburn Sherry K. Cox Kay A. Backues |
format |
Text |
author |
Jennifer J. Kilburn Sherry K. Cox Kay A. Backues |
spellingShingle |
Jennifer J. Kilburn Sherry K. Cox Kay A. Backues PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID, A LONG-ACTING CEPHALOSPORIN, IN AMERICAN FLAMINGOS (PHOENICOPTERUS RUBER) |
author_facet |
Jennifer J. Kilburn Sherry K. Cox Kay A. Backues |
author_sort |
Jennifer J. Kilburn |
title |
PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID, A LONG-ACTING CEPHALOSPORIN, IN AMERICAN FLAMINGOS (PHOENICOPTERUS RUBER) |
title_short |
PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID, A LONG-ACTING CEPHALOSPORIN, IN AMERICAN FLAMINGOS (PHOENICOPTERUS RUBER) |
title_full |
PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID, A LONG-ACTING CEPHALOSPORIN, IN AMERICAN FLAMINGOS (PHOENICOPTERUS RUBER) |
title_fullStr |
PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID, A LONG-ACTING CEPHALOSPORIN, IN AMERICAN FLAMINGOS (PHOENICOPTERUS RUBER) |
title_full_unstemmed |
PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE FREE ACID, A LONG-ACTING CEPHALOSPORIN, IN AMERICAN FLAMINGOS (PHOENICOPTERUS RUBER) |
title_sort |
pharmacokinetics of ceftiofur crystalline free acid, a long-acting cephalosporin, in american flamingos (phoenicopterus ruber) |
publisher |
American Association of Zoo Veterinarians |
publishDate |
2016 |
url |
https://doi.org/10.1638/2015-0278.1 |
op_coverage |
world |
genre |
Avian Studies |
genre_facet |
Avian Studies |
op_source |
https://doi.org/10.1638/2015-0278.1 |
op_relation |
doi:10.1638/2015-0278.1 |
op_rights |
All rights reserved. |
op_doi |
https://doi.org/10.1638/2015-0278.1 |
container_title |
Journal of Zoo and Wildlife Medicine |
container_volume |
47 |
container_issue |
2 |
container_start_page |
457 |
op_container_end_page |
462 |
_version_ |
1772813290222649344 |