MEDULLOBLASTOMA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBLIS)
A 3-yr-old female spayed grizzly bear (Ursus arctos horribilis) was evaluated for seizure activity along with lethargy, inappetence, dull mentation, and aggressive behavior. Magnetic resonance (MR) examination of the brain revealed a contrast-enhanced right cerebellar mass with multifocal smaller no...
Published in: | Journal of Zoo and Wildlife Medicine |
---|---|
Main Authors: | , , , , , , |
Format: | Text |
Language: | English |
Published: |
American Association of Zoo Veterinarians
2015
|
Subjects: | |
Online Access: | https://doi.org/10.1638/2014-0118.1 |
id |
ftbioone:10.1638/2014-0118.1 |
---|---|
record_format |
openpolar |
spelling |
ftbioone:10.1638/2014-0118.1 2023-07-30T04:07:22+02:00 MEDULLOBLASTOMA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBLIS) Jeffrey W. Mitchell Stephanie A. Thomovsky Annie V. Chen Arthur W. Layton Gary Haldorson Russell L. Tucker Gregory Roberts Jeffrey W. Mitchell Stephanie A. Thomovsky Annie V. Chen Arthur W. Layton Gary Haldorson Russell L. Tucker Gregory Roberts world 2015-09-01 text/HTML https://doi.org/10.1638/2014-0118.1 en eng American Association of Zoo Veterinarians doi:10.1638/2014-0118.1 All rights reserved. https://doi.org/10.1638/2014-0118.1 Text 2015 ftbioone https://doi.org/10.1638/2014-0118.1 2023-07-09T10:50:38Z A 3-yr-old female spayed grizzly bear (Ursus arctos horribilis) was evaluated for seizure activity along with lethargy, inappetence, dull mentation, and aggressive behavior. Magnetic resonance (MR) examination of the brain revealed a contrast-enhanced right cerebellar mass with multifocal smaller nodules located in the left cerebellum, thalamus, hippocampus, and cerebrum with resultant obstructive hydrocephalus. Cerebrospinal fluid analysis revealed mild mononuclear pleocytosis, with differentials including inflammatory versus neoplastic processes. Blood and cerebrospinal fluid were also submitted for polymerase chain reaction and agar gel immunodiffusion to rule out infectious causes of meningitis/encephalitis. While awaiting these results, the bear was placed on steroid and antibiotic therapy. Over the next week, the bear deteriorated; she died 1 wk after MR. A complete postmortem examination, including immunohistochemisty, revealed the cerebellar mass to be a medulloblastoma. This is the only case report, to the authors' knowledge, describing a medulloblastoma in a grizzly bear. Text Ursus arctos BioOne Online Journals Journal of Zoo and Wildlife Medicine 46 3 624 628 |
institution |
Open Polar |
collection |
BioOne Online Journals |
op_collection_id |
ftbioone |
language |
English |
description |
A 3-yr-old female spayed grizzly bear (Ursus arctos horribilis) was evaluated for seizure activity along with lethargy, inappetence, dull mentation, and aggressive behavior. Magnetic resonance (MR) examination of the brain revealed a contrast-enhanced right cerebellar mass with multifocal smaller nodules located in the left cerebellum, thalamus, hippocampus, and cerebrum with resultant obstructive hydrocephalus. Cerebrospinal fluid analysis revealed mild mononuclear pleocytosis, with differentials including inflammatory versus neoplastic processes. Blood and cerebrospinal fluid were also submitted for polymerase chain reaction and agar gel immunodiffusion to rule out infectious causes of meningitis/encephalitis. While awaiting these results, the bear was placed on steroid and antibiotic therapy. Over the next week, the bear deteriorated; she died 1 wk after MR. A complete postmortem examination, including immunohistochemisty, revealed the cerebellar mass to be a medulloblastoma. This is the only case report, to the authors' knowledge, describing a medulloblastoma in a grizzly bear. |
author2 |
Jeffrey W. Mitchell Stephanie A. Thomovsky Annie V. Chen Arthur W. Layton Gary Haldorson Russell L. Tucker Gregory Roberts |
format |
Text |
author |
Jeffrey W. Mitchell Stephanie A. Thomovsky Annie V. Chen Arthur W. Layton Gary Haldorson Russell L. Tucker Gregory Roberts |
spellingShingle |
Jeffrey W. Mitchell Stephanie A. Thomovsky Annie V. Chen Arthur W. Layton Gary Haldorson Russell L. Tucker Gregory Roberts MEDULLOBLASTOMA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBLIS) |
author_facet |
Jeffrey W. Mitchell Stephanie A. Thomovsky Annie V. Chen Arthur W. Layton Gary Haldorson Russell L. Tucker Gregory Roberts |
author_sort |
Jeffrey W. Mitchell |
title |
MEDULLOBLASTOMA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBLIS) |
title_short |
MEDULLOBLASTOMA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBLIS) |
title_full |
MEDULLOBLASTOMA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBLIS) |
title_fullStr |
MEDULLOBLASTOMA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBLIS) |
title_full_unstemmed |
MEDULLOBLASTOMA IN A GRIZZLY BEAR (URSUS ARCTOS HORRIBLIS) |
title_sort |
medulloblastoma in a grizzly bear (ursus arctos horriblis) |
publisher |
American Association of Zoo Veterinarians |
publishDate |
2015 |
url |
https://doi.org/10.1638/2014-0118.1 |
op_coverage |
world |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
https://doi.org/10.1638/2014-0118.1 |
op_relation |
doi:10.1638/2014-0118.1 |
op_rights |
All rights reserved. |
op_doi |
https://doi.org/10.1638/2014-0118.1 |
container_title |
Journal of Zoo and Wildlife Medicine |
container_volume |
46 |
container_issue |
3 |
container_start_page |
624 |
op_container_end_page |
628 |
_version_ |
1772820652001067008 |