SUCCESSFUL TREATMENT OF A SEVERE CASE OF FUSARIOMYCOSIS IN A BELUGA WHALE (DELPHINAPTERUS LEUCAS LEUCAS)
An adult male beluga whale (Delphinapterus leucas leucas) was presented with a 4-cm-diameter, raised, firm nodule on the medial aspect of the left pectoral fin. A fissure developed within the center of the nodule, which formed an ulcerated cyst-like lesion. The lesion rapidly progressed in size, and...
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American Association of Zoo Veterinarians
2012
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ftbioone:10.1638/2011-0268R1.1 2023-07-30T04:02:38+02:00 SUCCESSFUL TREATMENT OF A SEVERE CASE OF FUSARIOMYCOSIS IN A BELUGA WHALE (DELPHINAPTERUS LEUCAS LEUCAS) Lisa M. Naples Caryn P. Poll Ilze K. Berzins Lisa M. Naples Caryn P. Poll Ilze K. Berzins world 2012-09-20 text/HTML https://doi.org/10.1638/2011-0268R1.1 en eng American Association of Zoo Veterinarians doi:10.1638/2011-0268R1.1 All rights reserved. https://doi.org/10.1638/2011-0268R1.1 Text 2012 ftbioone https://doi.org/10.1638/2011-0268R1.1 2023-07-09T10:49:17Z An adult male beluga whale (Delphinapterus leucas leucas) was presented with a 4-cm-diameter, raised, firm nodule on the medial aspect of the left pectoral fin. A fissure developed within the center of the nodule, which formed an ulcerated cyst-like lesion. The lesion rapidly progressed in size, and, with peeling of material present within the cyst, the lesion flattened to a 36 × 25-cm cutaneous ulcer that extended into the axilla. Histopathologic features were consistent with lymphocytic and suppurative dermatitis with intralesional fungi. Fusarium solani was diagnosed by polymerase chain reaction (PCR). Fungal susceptibility testing was performed and revealed drug resistance to multiple antifungal medications tested individually and in combination therapies. Treatments used included serial surgical debridement of affected and surrounding tissue, topical application and regional infusion of various azole, and allylamine antifungals combined with either dimethyl sulfoxide or TricideB for absorption potentiation, and oral voriconazole administration. Although susceptibility testing revealed resistance to voriconazole, visible improvement of the lesion was noted after 6 weeks of oral voriconazole therapy. The voriconazole dosage was tapered based on serum levels and was administered over a 12-mo period. No local recurrence or new lesions were visible by 14 mo from first presentation. Text Beluga Beluga whale Beluga* Delphinapterus leucas BioOne Online Journals Journal of Zoo and Wildlife Medicine 43 3 596 602 |
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English |
description |
An adult male beluga whale (Delphinapterus leucas leucas) was presented with a 4-cm-diameter, raised, firm nodule on the medial aspect of the left pectoral fin. A fissure developed within the center of the nodule, which formed an ulcerated cyst-like lesion. The lesion rapidly progressed in size, and, with peeling of material present within the cyst, the lesion flattened to a 36 × 25-cm cutaneous ulcer that extended into the axilla. Histopathologic features were consistent with lymphocytic and suppurative dermatitis with intralesional fungi. Fusarium solani was diagnosed by polymerase chain reaction (PCR). Fungal susceptibility testing was performed and revealed drug resistance to multiple antifungal medications tested individually and in combination therapies. Treatments used included serial surgical debridement of affected and surrounding tissue, topical application and regional infusion of various azole, and allylamine antifungals combined with either dimethyl sulfoxide or TricideB for absorption potentiation, and oral voriconazole administration. Although susceptibility testing revealed resistance to voriconazole, visible improvement of the lesion was noted after 6 weeks of oral voriconazole therapy. The voriconazole dosage was tapered based on serum levels and was administered over a 12-mo period. No local recurrence or new lesions were visible by 14 mo from first presentation. |
author2 |
Lisa M. Naples Caryn P. Poll Ilze K. Berzins |
format |
Text |
author |
Lisa M. Naples Caryn P. Poll Ilze K. Berzins |
spellingShingle |
Lisa M. Naples Caryn P. Poll Ilze K. Berzins SUCCESSFUL TREATMENT OF A SEVERE CASE OF FUSARIOMYCOSIS IN A BELUGA WHALE (DELPHINAPTERUS LEUCAS LEUCAS) |
author_facet |
Lisa M. Naples Caryn P. Poll Ilze K. Berzins |
author_sort |
Lisa M. Naples |
title |
SUCCESSFUL TREATMENT OF A SEVERE CASE OF FUSARIOMYCOSIS IN A BELUGA WHALE (DELPHINAPTERUS LEUCAS LEUCAS) |
title_short |
SUCCESSFUL TREATMENT OF A SEVERE CASE OF FUSARIOMYCOSIS IN A BELUGA WHALE (DELPHINAPTERUS LEUCAS LEUCAS) |
title_full |
SUCCESSFUL TREATMENT OF A SEVERE CASE OF FUSARIOMYCOSIS IN A BELUGA WHALE (DELPHINAPTERUS LEUCAS LEUCAS) |
title_fullStr |
SUCCESSFUL TREATMENT OF A SEVERE CASE OF FUSARIOMYCOSIS IN A BELUGA WHALE (DELPHINAPTERUS LEUCAS LEUCAS) |
title_full_unstemmed |
SUCCESSFUL TREATMENT OF A SEVERE CASE OF FUSARIOMYCOSIS IN A BELUGA WHALE (DELPHINAPTERUS LEUCAS LEUCAS) |
title_sort |
successful treatment of a severe case of fusariomycosis in a beluga whale (delphinapterus leucas leucas) |
publisher |
American Association of Zoo Veterinarians |
publishDate |
2012 |
url |
https://doi.org/10.1638/2011-0268R1.1 |
op_coverage |
world |
genre |
Beluga Beluga whale Beluga* Delphinapterus leucas |
genre_facet |
Beluga Beluga whale Beluga* Delphinapterus leucas |
op_source |
https://doi.org/10.1638/2011-0268R1.1 |
op_relation |
doi:10.1638/2011-0268R1.1 |
op_rights |
All rights reserved. |
op_doi |
https://doi.org/10.1638/2011-0268R1.1 |
container_title |
Journal of Zoo and Wildlife Medicine |
container_volume |
43 |
container_issue |
3 |
container_start_page |
596 |
op_container_end_page |
602 |
_version_ |
1772813459740688384 |