Identification of Acute Phase Proteins and Assays Applicable in Nondomesticated Mammals
The serum concentration of acute phase proteins (APPs) increases dramatically in response to inflammation and tissue injury. APPs are clinically useful in a range of domesticated mammals; however, knowledge is limited in nondomesticated mammals. The detective ability of two assays for each of three...
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American Association of Zoo Veterinarians
2009
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ftbioone:10.1638/2007-0125.1 2023-07-30T04:04:57+02:00 Identification of Acute Phase Proteins and Assays Applicable in Nondomesticated Mammals Mads F. Bertelsen Mads Kjelgaard-Hansen Carsten Grøndahl Peter M. H. Heegaard Stine Jacobsen Mads F. Bertelsen Mads Kjelgaard-Hansen Carsten Grøndahl Peter M. H. Heegaard Stine Jacobsen world 2009-03-01 text/HTML https://doi.org/10.1638/2007-0125.1 en eng American Association of Zoo Veterinarians doi:10.1638/2007-0125.1 All rights reserved. https://doi.org/10.1638/2007-0125.1 Text 2009 ftbioone https://doi.org/10.1638/2007-0125.1 2023-07-09T10:47:38Z The serum concentration of acute phase proteins (APPs) increases dramatically in response to inflammation and tissue injury. APPs are clinically useful in a range of domesticated mammals; however, knowledge is limited in nondomesticated mammals. The detective ability of two assays for each of three potential APPs—serum amyloid A (SAA), C-reactive protein (CRP), and haptoglobin (Hp)—was evaluated in eight species. For SAA, a turbidimetric immunoassay (TIA) demonstrated significant detective abilities in the Asian elephant (Elaphas maximus), impala (Aepyceros melampus), musk ox (Ovibos moschatus), and chimpanzee (Pan troglodytes), as did an SAA enzyme-linked immunosorbent assay (ELISA) in the impala. For CRP, both TIA and ELISA had significant detective abilities in the chimpanzee. For Hp, a colorimetric assay demonstrated significant detective abilities in impala, musk ox, sitatunga (Tragelaphus spekeii), and chimpanzee, as did the Hp ELISA in the impala, musk ox, and sitatunga. In conclusion, these results suggest that assays for detection of relevant APPs in several nondomesticated animals are available. Text musk ox ovibos moschatus BioOne Online Journals Journal of Zoo and Wildlife Medicine 40 1 199 203 |
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The serum concentration of acute phase proteins (APPs) increases dramatically in response to inflammation and tissue injury. APPs are clinically useful in a range of domesticated mammals; however, knowledge is limited in nondomesticated mammals. The detective ability of two assays for each of three potential APPs—serum amyloid A (SAA), C-reactive protein (CRP), and haptoglobin (Hp)—was evaluated in eight species. For SAA, a turbidimetric immunoassay (TIA) demonstrated significant detective abilities in the Asian elephant (Elaphas maximus), impala (Aepyceros melampus), musk ox (Ovibos moschatus), and chimpanzee (Pan troglodytes), as did an SAA enzyme-linked immunosorbent assay (ELISA) in the impala. For CRP, both TIA and ELISA had significant detective abilities in the chimpanzee. For Hp, a colorimetric assay demonstrated significant detective abilities in impala, musk ox, sitatunga (Tragelaphus spekeii), and chimpanzee, as did the Hp ELISA in the impala, musk ox, and sitatunga. In conclusion, these results suggest that assays for detection of relevant APPs in several nondomesticated animals are available. |
author2 |
Mads F. Bertelsen Mads Kjelgaard-Hansen Carsten Grøndahl Peter M. H. Heegaard Stine Jacobsen |
format |
Text |
author |
Mads F. Bertelsen Mads Kjelgaard-Hansen Carsten Grøndahl Peter M. H. Heegaard Stine Jacobsen |
spellingShingle |
Mads F. Bertelsen Mads Kjelgaard-Hansen Carsten Grøndahl Peter M. H. Heegaard Stine Jacobsen Identification of Acute Phase Proteins and Assays Applicable in Nondomesticated Mammals |
author_facet |
Mads F. Bertelsen Mads Kjelgaard-Hansen Carsten Grøndahl Peter M. H. Heegaard Stine Jacobsen |
author_sort |
Mads F. Bertelsen |
title |
Identification of Acute Phase Proteins and Assays Applicable in Nondomesticated Mammals |
title_short |
Identification of Acute Phase Proteins and Assays Applicable in Nondomesticated Mammals |
title_full |
Identification of Acute Phase Proteins and Assays Applicable in Nondomesticated Mammals |
title_fullStr |
Identification of Acute Phase Proteins and Assays Applicable in Nondomesticated Mammals |
title_full_unstemmed |
Identification of Acute Phase Proteins and Assays Applicable in Nondomesticated Mammals |
title_sort |
identification of acute phase proteins and assays applicable in nondomesticated mammals |
publisher |
American Association of Zoo Veterinarians |
publishDate |
2009 |
url |
https://doi.org/10.1638/2007-0125.1 |
op_coverage |
world |
genre |
musk ox ovibos moschatus |
genre_facet |
musk ox ovibos moschatus |
op_source |
https://doi.org/10.1638/2007-0125.1 |
op_relation |
doi:10.1638/2007-0125.1 |
op_rights |
All rights reserved. |
op_doi |
https://doi.org/10.1638/2007-0125.1 |
container_title |
Journal of Zoo and Wildlife Medicine |
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40 |
container_issue |
1 |
container_start_page |
199 |
op_container_end_page |
203 |
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1772816604735733760 |