SUBACUTE ATROPINE TOXICITY IN A PYGMY SPERM WHALE, KOGIA BREVICEPS
Atropine, an anticholinergic agent commonly used in human and veterinary medicine, is reported to cause toxicity associated with its antimuscarinic action. A juvenile pygmy sperm whale, Kogia breviceps, was treated with atropine in an attempt to relieve symptoms similar to pyloric stenosis, as has b...
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American Association of Zoo Veterinarians
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ftbioone:10.1638/1042-7260(2002)033[0066:SATIAP]2.0.CO;2 2023-07-30T04:07:06+02:00 SUBACUTE ATROPINE TOXICITY IN A PYGMY SPERM WHALE, KOGIA BREVICEPS Charles A. Manire Lynne Byrd Howard L. Rhinehart Petra Cunningham-Smith David R. Smith Charles A. Manire Lynne Byrd Howard L. Rhinehart Petra Cunningham-Smith David R. Smith world 2002-03-01 text/HTML https://doi.org/10.1638/1042-7260(2002)033[0066:SATIAP]2.0.CO;2 en eng American Association of Zoo Veterinarians doi:10.1638/1042-7260(2002)033[0066:SATIAP]2.0.CO;2 All rights reserved. https://doi.org/10.1638/1042-7260(2002)033[0066:SATIAP]2.0.CO;2 Text 2002 ftbioone https://doi.org/10.1638/1042-7260(2002)033[0066:SATIAP]2.0.CO;2 2023-07-09T10:45:43Z Atropine, an anticholinergic agent commonly used in human and veterinary medicine, is reported to cause toxicity associated with its antimuscarinic action. A juvenile pygmy sperm whale, Kogia breviceps, was treated with atropine in an attempt to relieve symptoms similar to pyloric stenosis, as has been used in humans. Two doses of 0.01 mg/kg were given i.m., 12 hr apart, followed by three doses of 0.005 mg/kg i.m. s.i.d. over the next 3 days. Symptoms associated with atropine toxicity developed gradually and included hyperexcitability, a generalized ascending paralysis of body musculature, shallow, rapid respiration, vomiting, aspiration of seawater, and pulmonary edema. Treatment with physostigmine salicylate (two doses of 2 mg i.m., 1 hr apart) was effective in counteracting the paralysis, as well as other symptoms, beginning in as little as 17 min after the first dose, and the whale was back to swimming on its own after 8 hr. All overt symptoms of atropine toxicity were gone in about 24 hr, but there were other possible sequella that lasted much longer. Text Sperm whale BioOne Online Journals |
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English |
description |
Atropine, an anticholinergic agent commonly used in human and veterinary medicine, is reported to cause toxicity associated with its antimuscarinic action. A juvenile pygmy sperm whale, Kogia breviceps, was treated with atropine in an attempt to relieve symptoms similar to pyloric stenosis, as has been used in humans. Two doses of 0.01 mg/kg were given i.m., 12 hr apart, followed by three doses of 0.005 mg/kg i.m. s.i.d. over the next 3 days. Symptoms associated with atropine toxicity developed gradually and included hyperexcitability, a generalized ascending paralysis of body musculature, shallow, rapid respiration, vomiting, aspiration of seawater, and pulmonary edema. Treatment with physostigmine salicylate (two doses of 2 mg i.m., 1 hr apart) was effective in counteracting the paralysis, as well as other symptoms, beginning in as little as 17 min after the first dose, and the whale was back to swimming on its own after 8 hr. All overt symptoms of atropine toxicity were gone in about 24 hr, but there were other possible sequella that lasted much longer. |
author2 |
Charles A. Manire Lynne Byrd Howard L. Rhinehart Petra Cunningham-Smith David R. Smith |
format |
Text |
author |
Charles A. Manire Lynne Byrd Howard L. Rhinehart Petra Cunningham-Smith David R. Smith |
spellingShingle |
Charles A. Manire Lynne Byrd Howard L. Rhinehart Petra Cunningham-Smith David R. Smith SUBACUTE ATROPINE TOXICITY IN A PYGMY SPERM WHALE, KOGIA BREVICEPS |
author_facet |
Charles A. Manire Lynne Byrd Howard L. Rhinehart Petra Cunningham-Smith David R. Smith |
author_sort |
Charles A. Manire |
title |
SUBACUTE ATROPINE TOXICITY IN A PYGMY SPERM WHALE, KOGIA BREVICEPS |
title_short |
SUBACUTE ATROPINE TOXICITY IN A PYGMY SPERM WHALE, KOGIA BREVICEPS |
title_full |
SUBACUTE ATROPINE TOXICITY IN A PYGMY SPERM WHALE, KOGIA BREVICEPS |
title_fullStr |
SUBACUTE ATROPINE TOXICITY IN A PYGMY SPERM WHALE, KOGIA BREVICEPS |
title_full_unstemmed |
SUBACUTE ATROPINE TOXICITY IN A PYGMY SPERM WHALE, KOGIA BREVICEPS |
title_sort |
subacute atropine toxicity in a pygmy sperm whale, kogia breviceps |
publisher |
American Association of Zoo Veterinarians |
publishDate |
2002 |
url |
https://doi.org/10.1638/1042-7260(2002)033[0066:SATIAP]2.0.CO;2 |
op_coverage |
world |
genre |
Sperm whale |
genre_facet |
Sperm whale |
op_source |
https://doi.org/10.1638/1042-7260(2002)033[0066:SATIAP]2.0.CO;2 |
op_relation |
doi:10.1638/1042-7260(2002)033[0066:SATIAP]2.0.CO;2 |
op_rights |
All rights reserved. |
op_doi |
https://doi.org/10.1638/1042-7260(2002)033[0066:SATIAP]2.0.CO;2 |
_version_ |
1772820202337075200 |