AN IMMUNOHISTOCHEMICAL STUDY OF RETINOL-BINDING PROTEIN (RBP) IN LIVERS OF FREE-LIVING POLAR BEARS (URSUS MARITIMUS) FROM EAST GREENLAND
From 1999 to 2002 samples from 114 free-ranging polar bears (Ursus maritimus) were collected in the municipality of Scoresby Sound, East Greenland, to detect levels of organochlorines and potential histopathologic changes. Livers of 16 female polar bears from this group were evaluated histologically...
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American Association of Zoo Veterinarians
2005
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ftbioone:10.1638/03-058.1 2023-07-30T04:03:14+02:00 AN IMMUNOHISTOCHEMICAL STUDY OF RETINOL-BINDING PROTEIN (RBP) IN LIVERS OF FREE-LIVING POLAR BEARS (URSUS MARITIMUS) FROM EAST GREENLAND Annabelle Heier Christian Sonne Andrea Gröne Pall S. Leifsson Rune Dietz Erik W. Born Luca N. Bacciarini Annabelle Heier Christian Sonne Andrea Gröne Pall S. Leifsson Rune Dietz Erik W. Born Luca N. Bacciarini world 2005-09-01 text/HTML https://doi.org/10.1638/03-058.1 en eng American Association of Zoo Veterinarians doi:10.1638/03-058.1 All rights reserved. https://doi.org/10.1638/03-058.1 Text 2005 ftbioone https://doi.org/10.1638/03-058.1 2023-07-09T10:44:24Z From 1999 to 2002 samples from 114 free-ranging polar bears (Ursus maritimus) were collected in the municipality of Scoresby Sound, East Greenland, to detect levels of organochlorines and potential histopathologic changes. Livers of 16 female polar bears from this group were evaluated histologically and analyzed for hepatic retinol-binding protein by immunohistochemistry. Retinol-binding protein is the main transport protein for retinol, an important vitamin A metabolite in the polar bear. Only mild pathologic changes were noted on histologic evaluation of the livers. Small lymphocytic or lymphohistiocytic infiltrates were present in all the livers. Small lipid granulomas, mild periportal fibrosis, and bile duct proliferation were found in several cases. Immunohistochemistry for retinol-binding protein of hepatic tissue from free-ranging polar bears showed no distinct difference in staining intensity by a number of criteria: age, season (fasting and nonfasting), or lactation status. The staining was diffuse to finely stippled in the cytoplasm and showed very little variation among the animals. Because of the lack of macroscopic changes and the absence of severe histologic liver lesions, these polar bears were assumed to be healthy. The diffuse cytoplasmic retinol-binding protein staining in hepatocytes of free-ranging polar bears varies markedly from the prominent granular, less intense staining of captive polar bears investigated previously. Text East Greenland Greenland polar bear Scoresby Sound Ursus maritimus BioOne Online Journals Greenland Scoresby ENVELOPE(162.750,162.750,-66.567,-66.567) Journal of Zoo and Wildlife Medicine 36 3 440 446 |
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Open Polar |
collection |
BioOne Online Journals |
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ftbioone |
language |
English |
description |
From 1999 to 2002 samples from 114 free-ranging polar bears (Ursus maritimus) were collected in the municipality of Scoresby Sound, East Greenland, to detect levels of organochlorines and potential histopathologic changes. Livers of 16 female polar bears from this group were evaluated histologically and analyzed for hepatic retinol-binding protein by immunohistochemistry. Retinol-binding protein is the main transport protein for retinol, an important vitamin A metabolite in the polar bear. Only mild pathologic changes were noted on histologic evaluation of the livers. Small lymphocytic or lymphohistiocytic infiltrates were present in all the livers. Small lipid granulomas, mild periportal fibrosis, and bile duct proliferation were found in several cases. Immunohistochemistry for retinol-binding protein of hepatic tissue from free-ranging polar bears showed no distinct difference in staining intensity by a number of criteria: age, season (fasting and nonfasting), or lactation status. The staining was diffuse to finely stippled in the cytoplasm and showed very little variation among the animals. Because of the lack of macroscopic changes and the absence of severe histologic liver lesions, these polar bears were assumed to be healthy. The diffuse cytoplasmic retinol-binding protein staining in hepatocytes of free-ranging polar bears varies markedly from the prominent granular, less intense staining of captive polar bears investigated previously. |
author2 |
Annabelle Heier Christian Sonne Andrea Gröne Pall S. Leifsson Rune Dietz Erik W. Born Luca N. Bacciarini |
format |
Text |
author |
Annabelle Heier Christian Sonne Andrea Gröne Pall S. Leifsson Rune Dietz Erik W. Born Luca N. Bacciarini |
spellingShingle |
Annabelle Heier Christian Sonne Andrea Gröne Pall S. Leifsson Rune Dietz Erik W. Born Luca N. Bacciarini AN IMMUNOHISTOCHEMICAL STUDY OF RETINOL-BINDING PROTEIN (RBP) IN LIVERS OF FREE-LIVING POLAR BEARS (URSUS MARITIMUS) FROM EAST GREENLAND |
author_facet |
Annabelle Heier Christian Sonne Andrea Gröne Pall S. Leifsson Rune Dietz Erik W. Born Luca N. Bacciarini |
author_sort |
Annabelle Heier |
title |
AN IMMUNOHISTOCHEMICAL STUDY OF RETINOL-BINDING PROTEIN (RBP) IN LIVERS OF FREE-LIVING POLAR BEARS (URSUS MARITIMUS) FROM EAST GREENLAND |
title_short |
AN IMMUNOHISTOCHEMICAL STUDY OF RETINOL-BINDING PROTEIN (RBP) IN LIVERS OF FREE-LIVING POLAR BEARS (URSUS MARITIMUS) FROM EAST GREENLAND |
title_full |
AN IMMUNOHISTOCHEMICAL STUDY OF RETINOL-BINDING PROTEIN (RBP) IN LIVERS OF FREE-LIVING POLAR BEARS (URSUS MARITIMUS) FROM EAST GREENLAND |
title_fullStr |
AN IMMUNOHISTOCHEMICAL STUDY OF RETINOL-BINDING PROTEIN (RBP) IN LIVERS OF FREE-LIVING POLAR BEARS (URSUS MARITIMUS) FROM EAST GREENLAND |
title_full_unstemmed |
AN IMMUNOHISTOCHEMICAL STUDY OF RETINOL-BINDING PROTEIN (RBP) IN LIVERS OF FREE-LIVING POLAR BEARS (URSUS MARITIMUS) FROM EAST GREENLAND |
title_sort |
immunohistochemical study of retinol-binding protein (rbp) in livers of free-living polar bears (ursus maritimus) from east greenland |
publisher |
American Association of Zoo Veterinarians |
publishDate |
2005 |
url |
https://doi.org/10.1638/03-058.1 |
op_coverage |
world |
long_lat |
ENVELOPE(162.750,162.750,-66.567,-66.567) |
geographic |
Greenland Scoresby |
geographic_facet |
Greenland Scoresby |
genre |
East Greenland Greenland polar bear Scoresby Sound Ursus maritimus |
genre_facet |
East Greenland Greenland polar bear Scoresby Sound Ursus maritimus |
op_source |
https://doi.org/10.1638/03-058.1 |
op_relation |
doi:10.1638/03-058.1 |
op_rights |
All rights reserved. |
op_doi |
https://doi.org/10.1638/03-058.1 |
container_title |
Journal of Zoo and Wildlife Medicine |
container_volume |
36 |
container_issue |
3 |
container_start_page |
440 |
op_container_end_page |
446 |
_version_ |
1772814190329724928 |