Apparent resistance to brodifacoum in Rattus rattus in a New Zealand site with no history of anticoagulant-based rodent control
Context. Anticoagulants have been used in New Zealand for decades, but few data are available on the sustainability of these toxins for rodent control. It is important to regularly monitor for resistance in long-term brodifacoum-use areas and establish a database for future references. Aims. This st...
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ftbioone:10.1071/WR21064 2024-06-02T08:13:44+00:00 Apparent resistance to brodifacoum in Rattus rattus in a New Zealand site with no history of anticoagulant-based rodent control Suman P. K. Sran Brett G. Gartrell Penny Fisher Doug P. Armstrong Suman P. K. Sran Brett G. Gartrell Penny Fisher Doug P. Armstrong world 2022-07-07 text/HTML https://doi.org/10.1071/WR21064 en eng CSIRO Publishing doi:10.1071/WR21064 All rights reserved. https://doi.org/10.1071/WR21064 blood clotting response test Text 2022 ftbioone https://doi.org/10.1071/WR21064 2024-05-07T00:50:12Z Context. Anticoagulants have been used in New Zealand for decades, but few data are available on the sustainability of these toxins for rodent control. It is important to regularly monitor for resistance in long-term brodifacoum-use areas and establish a database for future references. Aims. This study aimed to estimate the effective dose (ED50) of brodifacoum for ship rats from an area of New Zealand with no history of brodifacoum use, in order to establish a blood-clotting response test for assessing resistance in rodent populations from other areas. Methods. A ranging study was conducted whereby successive groups of ship rats were administered brodifacoum doses that were increased or decreased progressively, until an International Normalised Ratio (INR) of 3.6 was reached. Linear regression was used to model the relationship between dose and INR, and ED50 dose was estimated using the resulting model. Results. None of the rats appeared susceptible to brodifacoum at previously reported LD50 exposures for this species. The ED50 of brodifacoum was estimated to be 2.88 mg/kg for males and 3.81 mg/kg for females. These values are 6–8 times greater than the previously published lethal dose values for ship rats in New Zealand. Conclusions. Blood-clotting inhibition was detected in the rats only following high doses of brodifacoum, which may indicate resistance within the sampled population. Implications. Relatively low susceptibility, or resistance, to brodifacoum in New Zealand ship rats may be mediated by spatial connections between areas with different histories and patterns of anticoagulant rodenticide use. Text Rattus rattus BioOne Online Journals New Zealand Wildlife Research 50 1 28 38 |
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blood clotting response test |
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blood clotting response test Suman P. K. Sran Brett G. Gartrell Penny Fisher Doug P. Armstrong Apparent resistance to brodifacoum in Rattus rattus in a New Zealand site with no history of anticoagulant-based rodent control |
topic_facet |
blood clotting response test |
description |
Context. Anticoagulants have been used in New Zealand for decades, but few data are available on the sustainability of these toxins for rodent control. It is important to regularly monitor for resistance in long-term brodifacoum-use areas and establish a database for future references. Aims. This study aimed to estimate the effective dose (ED50) of brodifacoum for ship rats from an area of New Zealand with no history of brodifacoum use, in order to establish a blood-clotting response test for assessing resistance in rodent populations from other areas. Methods. A ranging study was conducted whereby successive groups of ship rats were administered brodifacoum doses that were increased or decreased progressively, until an International Normalised Ratio (INR) of 3.6 was reached. Linear regression was used to model the relationship between dose and INR, and ED50 dose was estimated using the resulting model. Results. None of the rats appeared susceptible to brodifacoum at previously reported LD50 exposures for this species. The ED50 of brodifacoum was estimated to be 2.88 mg/kg for males and 3.81 mg/kg for females. These values are 6–8 times greater than the previously published lethal dose values for ship rats in New Zealand. Conclusions. Blood-clotting inhibition was detected in the rats only following high doses of brodifacoum, which may indicate resistance within the sampled population. Implications. Relatively low susceptibility, or resistance, to brodifacoum in New Zealand ship rats may be mediated by spatial connections between areas with different histories and patterns of anticoagulant rodenticide use. |
author2 |
Suman P. K. Sran Brett G. Gartrell Penny Fisher Doug P. Armstrong |
format |
Text |
author |
Suman P. K. Sran Brett G. Gartrell Penny Fisher Doug P. Armstrong |
author_facet |
Suman P. K. Sran Brett G. Gartrell Penny Fisher Doug P. Armstrong |
author_sort |
Suman P. K. Sran |
title |
Apparent resistance to brodifacoum in Rattus rattus in a New Zealand site with no history of anticoagulant-based rodent control |
title_short |
Apparent resistance to brodifacoum in Rattus rattus in a New Zealand site with no history of anticoagulant-based rodent control |
title_full |
Apparent resistance to brodifacoum in Rattus rattus in a New Zealand site with no history of anticoagulant-based rodent control |
title_fullStr |
Apparent resistance to brodifacoum in Rattus rattus in a New Zealand site with no history of anticoagulant-based rodent control |
title_full_unstemmed |
Apparent resistance to brodifacoum in Rattus rattus in a New Zealand site with no history of anticoagulant-based rodent control |
title_sort |
apparent resistance to brodifacoum in rattus rattus in a new zealand site with no history of anticoagulant-based rodent control |
publisher |
CSIRO Publishing |
publishDate |
2022 |
url |
https://doi.org/10.1071/WR21064 |
op_coverage |
world |
geographic |
New Zealand |
geographic_facet |
New Zealand |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_source |
https://doi.org/10.1071/WR21064 |
op_relation |
doi:10.1071/WR21064 |
op_rights |
All rights reserved. |
op_doi |
https://doi.org/10.1071/WR21064 |
container_title |
Wildlife Research |
container_volume |
50 |
container_issue |
1 |
container_start_page |
28 |
op_container_end_page |
38 |
_version_ |
1800737328204873728 |