Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5–9 years in Greenland, Ukraine and Poland
Abstract Background Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland)...
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ftbiomed:oai:biomedcentral.com:s12889-015-1465-3 2023-05-15T16:28:21+02:00 Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5–9 years in Greenland, Ukraine and Poland Høyer, Birgit Ramlau-Hansen, Cecilia Pedersen, Henning Góralczyk, Katarzyna Chumak, Lyubov Jönsson, Bo Bonde, Jens Toft, Gunnar 2015-02-14 http://www.biomedcentral.com/1471-2458/15/146 en eng BioMed Central Ltd. http://www.biomedcentral.com/1471-2458/15/146 Copyright 2015 Høyer et al.; licensee BioMed Central. Child motor development Developmental milestones Dichlorodiphenyldichloroethylene (DDE) Organochlorines Polychlorinated biphenyls (PCBs) Prenatal exposure Research article 2015 ftbiomed 2015-02-22T00:51:41Z Abstract Background Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland) and Greenland (N = 1,103) between the years 2002 and 2012, we examined relations of prenatal exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p′-DDE) and 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB-153) on motor development and developmental milestones; crawling, standing-up and walking. Methods CB-153 and p,p′-DDE were measured in maternal blood in second or third trimester of pregnancy. Motor development was measured in terms of the parentally assessed screening tool Developmental Coordination Disorder Questionnaire 2007 and developmental milestones were assessed via retrospective parental reports of child age at the first time of crawling, standing-up and walking. Results We saw no associations between tertiles of CB-153 and p,p′-DDE or log-transformed exposures and retrospective reports of the developmental milestones crawling, standing-up and walking in infancy or the motor skills measured as developmental coordination disorder at young school age. Conclusions In utero exposure to CB-153 and p,p′-DDE was not associated with parentally retrospectively assessed developmental milestones in infancy or parentally assessed motor skills at young school age. The use of a more sensitive outcome measure may be warranted if subtle effects should be identified. Article in Journal/Newspaper Greenland BioMed Central Greenland |
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Open Polar |
collection |
BioMed Central |
op_collection_id |
ftbiomed |
language |
English |
topic |
Child motor development Developmental milestones Dichlorodiphenyldichloroethylene (DDE) Organochlorines Polychlorinated biphenyls (PCBs) Prenatal exposure |
spellingShingle |
Child motor development Developmental milestones Dichlorodiphenyldichloroethylene (DDE) Organochlorines Polychlorinated biphenyls (PCBs) Prenatal exposure Høyer, Birgit Ramlau-Hansen, Cecilia Pedersen, Henning Góralczyk, Katarzyna Chumak, Lyubov Jönsson, Bo Bonde, Jens Toft, Gunnar Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5–9 years in Greenland, Ukraine and Poland |
topic_facet |
Child motor development Developmental milestones Dichlorodiphenyldichloroethylene (DDE) Organochlorines Polychlorinated biphenyls (PCBs) Prenatal exposure |
description |
Abstract Background Prior studies on the association between prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) and child motor development have found contradicting results. Using data collected in the INUENDO cohort in Kharkiv (Ukraine), Warsaw (Poland) and Greenland (N = 1,103) between the years 2002 and 2012, we examined relations of prenatal exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p′-DDE) and 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB-153) on motor development and developmental milestones; crawling, standing-up and walking. Methods CB-153 and p,p′-DDE were measured in maternal blood in second or third trimester of pregnancy. Motor development was measured in terms of the parentally assessed screening tool Developmental Coordination Disorder Questionnaire 2007 and developmental milestones were assessed via retrospective parental reports of child age at the first time of crawling, standing-up and walking. Results We saw no associations between tertiles of CB-153 and p,p′-DDE or log-transformed exposures and retrospective reports of the developmental milestones crawling, standing-up and walking in infancy or the motor skills measured as developmental coordination disorder at young school age. Conclusions In utero exposure to CB-153 and p,p′-DDE was not associated with parentally retrospectively assessed developmental milestones in infancy or parentally assessed motor skills at young school age. The use of a more sensitive outcome measure may be warranted if subtle effects should be identified. |
format |
Article in Journal/Newspaper |
author |
Høyer, Birgit Ramlau-Hansen, Cecilia Pedersen, Henning Góralczyk, Katarzyna Chumak, Lyubov Jönsson, Bo Bonde, Jens Toft, Gunnar |
author_facet |
Høyer, Birgit Ramlau-Hansen, Cecilia Pedersen, Henning Góralczyk, Katarzyna Chumak, Lyubov Jönsson, Bo Bonde, Jens Toft, Gunnar |
author_sort |
Høyer, Birgit |
title |
Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5–9 years in Greenland, Ukraine and Poland |
title_short |
Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5–9 years in Greenland, Ukraine and Poland |
title_full |
Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5–9 years in Greenland, Ukraine and Poland |
title_fullStr |
Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5–9 years in Greenland, Ukraine and Poland |
title_full_unstemmed |
Motor development following in utero exposure to organochlorines: a follow-up study of children aged 5–9 years in Greenland, Ukraine and Poland |
title_sort |
motor development following in utero exposure to organochlorines: a follow-up study of children aged 5–9 years in greenland, ukraine and poland |
publisher |
BioMed Central Ltd. |
publishDate |
2015 |
url |
http://www.biomedcentral.com/1471-2458/15/146 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_relation |
http://www.biomedcentral.com/1471-2458/15/146 |
op_rights |
Copyright 2015 Høyer et al.; licensee BioMed Central. |
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1766017988882857984 |