Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study
Abstract Background Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-di...
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ftbiomed:oai:biomedcentral.com:s12882-016-0386-4 2023-05-15T18:34:49+02:00 Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study Stefansson, Vidar Schei, Jørgen Jenssen, Trond Melsom, Toralf Eriksen, Bjørn 2016-11-10 http://www.biomedcentral.com/1471-2369/17/172 en eng BioMed Central Ltd. http://www.biomedcentral.com/1471-2369/17/172 Copyright 2016 The Author(s). Body mass index Chronic kidney disease Glomerular filtration rate Glomerular hyperfiltration Waist circumference Waist-hip ratio Research article 2016 ftbiomed 2016-11-27T01:39:34Z Abstract Background Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition of hyperfiltration and the limited precision of high-range GFR estimations with creatinine and/or cystatin C. Methods 1555 middle-aged participants without diabetes, renal or cardiovascular disease were enrolled from the general population in the Renal Iohexol Clearance Survey from the 6th Tromsø Study (RENIS-T6) between 2007 and 2009. Obesity was assessed using the body mass index (BMI), waist circumference (WC) and the waist-hip ratio (WHR). GFR was measured by iohexol clearance. Dichotomous variables for hyperfiltration were based on two alternative definitions using unadjusted GFR (mL/min) above the 90th percentile. The 90th percentile was age-, sex- and height-specific in one definition and age-, sex-, height- and weight-specific in the other. Results In multivariable adjusted logistic regression models, only WHR was consistently associated with hyperfiltration based on both definitions. For the definition based on the age-, sex-, height- and weight-specific 90th percentile, the association with the WHR (odds ratios (95 % confidence intervals)) for hyperfiltration was 1.48 (1.08–2.02) per 0.10 WHR increase. Conclusions Central obesity is associated with hyperfiltration in the general population. The WHR may serve as a better indicator of the renal effects of obesity than BMI or WC. Article in Journal/Newspaper Tromsø BioMed Central The Waist ENVELOPE(-61.404,-61.404,-64.639,-64.639) Tromsø |
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Open Polar |
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BioMed Central |
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ftbiomed |
language |
English |
topic |
Body mass index Chronic kidney disease Glomerular filtration rate Glomerular hyperfiltration Waist circumference Waist-hip ratio |
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Body mass index Chronic kidney disease Glomerular filtration rate Glomerular hyperfiltration Waist circumference Waist-hip ratio Stefansson, Vidar Schei, Jørgen Jenssen, Trond Melsom, Toralf Eriksen, Bjørn Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
topic_facet |
Body mass index Chronic kidney disease Glomerular filtration rate Glomerular hyperfiltration Waist circumference Waist-hip ratio |
description |
Abstract Background Obesity is a risk factor for end-stage renal disease. Renal hyperfiltration, defined as an abnormally high glomerular filtration rate (GFR), is a link in the causal chain between diabetes and chronic kidney disease. Whether obesity is associated with hyperfiltration in the non-diabetic general population, remains unresolved due to a lack of consensus regarding the definition of hyperfiltration and the limited precision of high-range GFR estimations with creatinine and/or cystatin C. Methods 1555 middle-aged participants without diabetes, renal or cardiovascular disease were enrolled from the general population in the Renal Iohexol Clearance Survey from the 6th Tromsø Study (RENIS-T6) between 2007 and 2009. Obesity was assessed using the body mass index (BMI), waist circumference (WC) and the waist-hip ratio (WHR). GFR was measured by iohexol clearance. Dichotomous variables for hyperfiltration were based on two alternative definitions using unadjusted GFR (mL/min) above the 90th percentile. The 90th percentile was age-, sex- and height-specific in one definition and age-, sex-, height- and weight-specific in the other. Results In multivariable adjusted logistic regression models, only WHR was consistently associated with hyperfiltration based on both definitions. For the definition based on the age-, sex-, height- and weight-specific 90th percentile, the association with the WHR (odds ratios (95 % confidence intervals)) for hyperfiltration was 1.48 (1.08–2.02) per 0.10 WHR increase. Conclusions Central obesity is associated with hyperfiltration in the general population. The WHR may serve as a better indicator of the renal effects of obesity than BMI or WC. |
format |
Article in Journal/Newspaper |
author |
Stefansson, Vidar Schei, Jørgen Jenssen, Trond Melsom, Toralf Eriksen, Bjørn |
author_facet |
Stefansson, Vidar Schei, Jørgen Jenssen, Trond Melsom, Toralf Eriksen, Bjørn |
author_sort |
Stefansson, Vidar |
title |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_short |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_full |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_fullStr |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_full_unstemmed |
Central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
title_sort |
central obesity associates with renal hyperfiltration in the non-diabetic general population: a cross-sectional study |
publisher |
BioMed Central Ltd. |
publishDate |
2016 |
url |
http://www.biomedcentral.com/1471-2369/17/172 |
long_lat |
ENVELOPE(-61.404,-61.404,-64.639,-64.639) |
geographic |
The Waist Tromsø |
geographic_facet |
The Waist Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
http://www.biomedcentral.com/1471-2369/17/172 |
op_rights |
Copyright 2016 The Author(s). |
_version_ |
1766219749884166144 |