Human Puumala hantavirus infection in northern Sweden; increased seroprevalence and association to risk and health factors
Abstract Background The rodent borne Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome in central and northern Europe. The number of cases has increased and northern Sweden has experienced large outbreaks in 1998 and 2006–2007 which raised questions regarding the level of immun...
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ftbiomed:oai:biomedcentral.com:s12879-016-1879-2 2023-05-15T17:44:18+02:00 Human Puumala hantavirus infection in northern Sweden; increased seroprevalence and association to risk and health factors Bergstedt Oscarsson, Kristina Brorstad, Alette Baudin, Maria Lindberg, Anne Forssén, Annika Evander, Magnus Eriksson, Marie Ahlm, Clas 2016-10-13 http://www.biomedcentral.com/1471-2334/16/566 en eng BioMed Central Ltd. http://www.biomedcentral.com/1471-2334/16/566 Copyright 2016 The Author(s). Emerging infection Hantavirus Haemhorrhagic fever with renal syndrome Puumala seroepidemiology Risk factors Research article 2016 ftbiomed 2016-10-16T00:01:07Z Abstract Background The rodent borne Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome in central and northern Europe. The number of cases has increased and northern Sweden has experienced large outbreaks in 1998 and 2006–2007 which raised questions regarding the level of immunity in the human population. Methods A randomly selected population aged between 25 and 74 years from northern Sweden were invited during 2009 to participate in a WHO project for monitoring of trends and determinants in cardiovascular disease. Health and risk factors were evaluated and sera from 1,600 participants were available for analysis for specific PUUV IgG antibodies using a recombinant PUUV nucleocapsid protein ELISA. Results The overall seroprevalence in the investigated population was 13.4 %, which is a 50 % increase compared to a similar study only two decades previously. The prevalence of PUUV IgG increased with age, and among 65–75 years it was 22 %. More men (15.3 %) than women (11.4 %) were seropositive ( p < 0.05). The identified risk factors were smoking (OR = 1.67), living in rural areas (OR = 1.92), and owning farmland or forest (OR = 2.44). No associations were found between previous PUUV exposure and chronic lung disease, diabetes, hypertension, renal dysfunction, stroke or myocardial infarction. Conclusions PUUV is a common infection in northern Sweden and there is a high life time risk to acquire PUUV infection in endemic areas. Certain risk factors as living in rural areas and smoking were identified. Groups with increased risk should be targeted for future vaccination when available, and should also be informed about appropriate protection from rodent secreta. Article in Journal/Newspaper Northern Sweden BioMed Central |
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Open Polar |
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BioMed Central |
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ftbiomed |
language |
English |
topic |
Emerging infection Hantavirus Haemhorrhagic fever with renal syndrome Puumala seroepidemiology Risk factors |
spellingShingle |
Emerging infection Hantavirus Haemhorrhagic fever with renal syndrome Puumala seroepidemiology Risk factors Bergstedt Oscarsson, Kristina Brorstad, Alette Baudin, Maria Lindberg, Anne Forssén, Annika Evander, Magnus Eriksson, Marie Ahlm, Clas Human Puumala hantavirus infection in northern Sweden; increased seroprevalence and association to risk and health factors |
topic_facet |
Emerging infection Hantavirus Haemhorrhagic fever with renal syndrome Puumala seroepidemiology Risk factors |
description |
Abstract Background The rodent borne Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome in central and northern Europe. The number of cases has increased and northern Sweden has experienced large outbreaks in 1998 and 2006–2007 which raised questions regarding the level of immunity in the human population. Methods A randomly selected population aged between 25 and 74 years from northern Sweden were invited during 2009 to participate in a WHO project for monitoring of trends and determinants in cardiovascular disease. Health and risk factors were evaluated and sera from 1,600 participants were available for analysis for specific PUUV IgG antibodies using a recombinant PUUV nucleocapsid protein ELISA. Results The overall seroprevalence in the investigated population was 13.4 %, which is a 50 % increase compared to a similar study only two decades previously. The prevalence of PUUV IgG increased with age, and among 65–75 years it was 22 %. More men (15.3 %) than women (11.4 %) were seropositive ( p < 0.05). The identified risk factors were smoking (OR = 1.67), living in rural areas (OR = 1.92), and owning farmland or forest (OR = 2.44). No associations were found between previous PUUV exposure and chronic lung disease, diabetes, hypertension, renal dysfunction, stroke or myocardial infarction. Conclusions PUUV is a common infection in northern Sweden and there is a high life time risk to acquire PUUV infection in endemic areas. Certain risk factors as living in rural areas and smoking were identified. Groups with increased risk should be targeted for future vaccination when available, and should also be informed about appropriate protection from rodent secreta. |
format |
Article in Journal/Newspaper |
author |
Bergstedt Oscarsson, Kristina Brorstad, Alette Baudin, Maria Lindberg, Anne Forssén, Annika Evander, Magnus Eriksson, Marie Ahlm, Clas |
author_facet |
Bergstedt Oscarsson, Kristina Brorstad, Alette Baudin, Maria Lindberg, Anne Forssén, Annika Evander, Magnus Eriksson, Marie Ahlm, Clas |
author_sort |
Bergstedt Oscarsson, Kristina |
title |
Human Puumala hantavirus infection in northern Sweden; increased seroprevalence and association to risk and health factors |
title_short |
Human Puumala hantavirus infection in northern Sweden; increased seroprevalence and association to risk and health factors |
title_full |
Human Puumala hantavirus infection in northern Sweden; increased seroprevalence and association to risk and health factors |
title_fullStr |
Human Puumala hantavirus infection in northern Sweden; increased seroprevalence and association to risk and health factors |
title_full_unstemmed |
Human Puumala hantavirus infection in northern Sweden; increased seroprevalence and association to risk and health factors |
title_sort |
human puumala hantavirus infection in northern sweden; increased seroprevalence and association to risk and health factors |
publisher |
BioMed Central Ltd. |
publishDate |
2016 |
url |
http://www.biomedcentral.com/1471-2334/16/566 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
http://www.biomedcentral.com/1471-2334/16/566 |
op_rights |
Copyright 2016 The Author(s). |
_version_ |
1766146513110564864 |