De novo assembly and transcriptome analysis of Atlantic salmon macrophage/dendritic-like TO cells following type I IFN treatment and Salmonid alphavirus subtype-3 infection

• Main Authors: Xu, Cheng, Evensen, Øystein, Munang’andu, Hetron
• Format: Article in Journal/Newspaper
• Language: English
• Published: BioMed Central Ltd. 2015
• Subjects: Interferon; Salmonid alphavirus; Transcriptome; RNA-seq; De novo assembly; Sav’; Atlantic salmon; Salmo salar
• Online Access: http://www.biomedcentral.com/1471-2164/16/96

Abstract Background Interferons (IFN) are cytokines secreted by vertebrate cells involved in activation of signaling pathways that direct the synthesis of antiviral genes. To gain a global understanding of antiviral genes induced by type I IFNs in salmonids, we used RNA-seq to characterize the trans...