A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis)
Abstract Background The androgen receptor , an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen recep...
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ftbiomed:oai:biomedcentral.com:s12863-015-0284-y 2023-05-15T18:50:19+02:00 A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) Prentice, Melanie Bowman, Jeff Wilson, Paul 2015-10-26 http://www.biomedcentral.com/1471-2156/16/125 en eng BioMed Central Ltd. http://www.biomedcentral.com/1471-2156/16/125 Copyright 2015 Prentice et al. Somatic mosaicism Androgen receptor Canada lynx Trinucleotide repeats Research article 2015 ftbiomed 2015-11-01T01:09:44Z Abstract Background The androgen receptor , an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene in carnivores reported somatic mosaicism in the tissues of a number of species including Eurasian lynx ( Lynx lynx ). We investigated this claim in a closely related species, Canada lynx ( Lynx canadensis ). The presence of somatic mosaicism in lynx tissues could have implications for the future study of exonic trinucleotide repeats in landscape genomic studies, in which the accurate reporting of genotypes would be highly problematic. Methods To determine whether mosaicism occurs in Canada lynx, two lynx individuals were sampled for a variety of tissue types (lynx 1) and tissue locations (lynx 1 and 2), and 1,672 individuals of known sex were genotyped to further rule out mosaicism. Results We found no evidence of mosaicism in tissues from the two necropsied individuals, or any of our genotyped samples. Conclusions Our results indicate that mosaicism does not manifest in Canada lynx. Therefore, the use of hide samples for further work involving trinucleotide repeat polymorphisms in Canada lynx is warranted. Article in Journal/Newspaper Lynx Lynx lynx lynx BioMed Central Canada |
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language |
English |
topic |
Somatic mosaicism Androgen receptor Canada lynx Trinucleotide repeats |
spellingShingle |
Somatic mosaicism Androgen receptor Canada lynx Trinucleotide repeats Prentice, Melanie Bowman, Jeff Wilson, Paul A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
topic_facet |
Somatic mosaicism Androgen receptor Canada lynx Trinucleotide repeats |
description |
Abstract Background The androgen receptor , an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene in carnivores reported somatic mosaicism in the tissues of a number of species including Eurasian lynx ( Lynx lynx ). We investigated this claim in a closely related species, Canada lynx ( Lynx canadensis ). The presence of somatic mosaicism in lynx tissues could have implications for the future study of exonic trinucleotide repeats in landscape genomic studies, in which the accurate reporting of genotypes would be highly problematic. Methods To determine whether mosaicism occurs in Canada lynx, two lynx individuals were sampled for a variety of tissue types (lynx 1) and tissue locations (lynx 1 and 2), and 1,672 individuals of known sex were genotyped to further rule out mosaicism. Results We found no evidence of mosaicism in tissues from the two necropsied individuals, or any of our genotyped samples. Conclusions Our results indicate that mosaicism does not manifest in Canada lynx. Therefore, the use of hide samples for further work involving trinucleotide repeat polymorphisms in Canada lynx is warranted. |
format |
Article in Journal/Newspaper |
author |
Prentice, Melanie Bowman, Jeff Wilson, Paul |
author_facet |
Prentice, Melanie Bowman, Jeff Wilson, Paul |
author_sort |
Prentice, Melanie |
title |
A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_short |
A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_full |
A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_fullStr |
A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_full_unstemmed |
A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_sort |
test of somatic mosaicism in the androgen receptor gene of canada lynx (lynx canadensis) |
publisher |
BioMed Central Ltd. |
publishDate |
2015 |
url |
http://www.biomedcentral.com/1471-2156/16/125 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
Lynx Lynx lynx lynx |
genre_facet |
Lynx Lynx lynx lynx |
op_relation |
http://www.biomedcentral.com/1471-2156/16/125 |
op_rights |
Copyright 2015 Prentice et al. |
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1766244034676785152 |