Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density
Abstract Background Increased mammographic density is one of the strongest independent risk factors for breast cancer. It is believed that one third of breast cancers are derived from breasts with more than 50% density. Mammographic density is affected by age, BMI, parity, and genetic predisposition...
Main Authors: | , , , , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BioMed Central Ltd.
2010
|
Subjects: | |
Online Access: | http://www.biomedcentral.com/1755-8794/3/9 |
id |
ftbiomed:oai:biomedcentral.com:1755-8794-3-9 |
---|---|
record_format |
openpolar |
spelling |
ftbiomed:oai:biomedcentral.com:1755-8794-3-9 2023-05-15T18:34:52+02:00 Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density Biong, Margarethe Gram, Inger T Brill, Ilene Johansen, Fredrik Solvang, Hiroko K Alnaes, Grethe IG Fagerheim, Toril Bremnes, Yngve Chanock, Stephen J Burdett, Laurie Yeager, Meredith Ursin, Giske Kristensen, Vessela N 2010-03-19 http://www.biomedcentral.com/1755-8794/3/9 en eng BioMed Central Ltd. http://www.biomedcentral.com/1755-8794/3/9 Copyright 2010 Biong et al; licensee BioMed Central Ltd. Research article 2010 ftbiomed 2010-04-18T00:24:24Z Abstract Background Increased mammographic density is one of the strongest independent risk factors for breast cancer. It is believed that one third of breast cancers are derived from breasts with more than 50% density. Mammographic density is affected by age, BMI, parity, and genetic predisposition. It is also greatly influenced by hormonal and growth factor changes in a woman's life cycle, spanning from puberty through adult to menopause. Genetic variations in genes coding for hormones and growth factors involved in development of the breast are therefore of great interest. The associations between genetic polymorphisms in genes from the IGF pathway on mammographic density and circulating levels of IGF1, its binding protein IGFBP3, and their ratio in postmenopausal women are reported here. Methods Samples from 964 postmenopausal Norwegian women aged 55-71 years were collected as a part of the Tromsø Mammography and Breast Cancer Study. All samples were genotyped for 25 SNPs in IGF1, IGF2, IGF1R, IGF2R, IGFALS and IGFBP3 using Taqman (ABI). The main statistical analyses were conducted with the PROC HAPLOTYPE procedure within SAS/GENETICS™ (SAS 9.1.3). Results The haplotype analysis revealed six haploblocks within the studied genes. Of those, four had significant associations with circulating levels of IGF1 or IGFBP3 and/or mammographic density. One haplotype variant in the IGF1 gene was found to be associated with mammographic density. Within the IGF2 gene one haplotype variant was associated with levels of both IGF1 and IGFBP3. Two haplotype variants in the IGF2R were associated with the level of IGF1. Both variants of the IGFBP3 haplotype were associated with the IGFBP3 level and indicate regulation in cis. Conclusion Polymorphisms within the IGF1 gene and related genes were associated with plasma levels of IGF1, IGFBP3 and mammographic density in this study of postmenopausal women. Article in Journal/Newspaper Tromsø BioMed Central Tromsø |
institution |
Open Polar |
collection |
BioMed Central |
op_collection_id |
ftbiomed |
language |
English |
description |
Abstract Background Increased mammographic density is one of the strongest independent risk factors for breast cancer. It is believed that one third of breast cancers are derived from breasts with more than 50% density. Mammographic density is affected by age, BMI, parity, and genetic predisposition. It is also greatly influenced by hormonal and growth factor changes in a woman's life cycle, spanning from puberty through adult to menopause. Genetic variations in genes coding for hormones and growth factors involved in development of the breast are therefore of great interest. The associations between genetic polymorphisms in genes from the IGF pathway on mammographic density and circulating levels of IGF1, its binding protein IGFBP3, and their ratio in postmenopausal women are reported here. Methods Samples from 964 postmenopausal Norwegian women aged 55-71 years were collected as a part of the Tromsø Mammography and Breast Cancer Study. All samples were genotyped for 25 SNPs in IGF1, IGF2, IGF1R, IGF2R, IGFALS and IGFBP3 using Taqman (ABI). The main statistical analyses were conducted with the PROC HAPLOTYPE procedure within SAS/GENETICS™ (SAS 9.1.3). Results The haplotype analysis revealed six haploblocks within the studied genes. Of those, four had significant associations with circulating levels of IGF1 or IGFBP3 and/or mammographic density. One haplotype variant in the IGF1 gene was found to be associated with mammographic density. Within the IGF2 gene one haplotype variant was associated with levels of both IGF1 and IGFBP3. Two haplotype variants in the IGF2R were associated with the level of IGF1. Both variants of the IGFBP3 haplotype were associated with the IGFBP3 level and indicate regulation in cis. Conclusion Polymorphisms within the IGF1 gene and related genes were associated with plasma levels of IGF1, IGFBP3 and mammographic density in this study of postmenopausal women. |
format |
Article in Journal/Newspaper |
author |
Biong, Margarethe Gram, Inger T Brill, Ilene Johansen, Fredrik Solvang, Hiroko K Alnaes, Grethe IG Fagerheim, Toril Bremnes, Yngve Chanock, Stephen J Burdett, Laurie Yeager, Meredith Ursin, Giske Kristensen, Vessela N |
spellingShingle |
Biong, Margarethe Gram, Inger T Brill, Ilene Johansen, Fredrik Solvang, Hiroko K Alnaes, Grethe IG Fagerheim, Toril Bremnes, Yngve Chanock, Stephen J Burdett, Laurie Yeager, Meredith Ursin, Giske Kristensen, Vessela N Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density |
author_facet |
Biong, Margarethe Gram, Inger T Brill, Ilene Johansen, Fredrik Solvang, Hiroko K Alnaes, Grethe IG Fagerheim, Toril Bremnes, Yngve Chanock, Stephen J Burdett, Laurie Yeager, Meredith Ursin, Giske Kristensen, Vessela N |
author_sort |
Biong, Margarethe |
title |
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density |
title_short |
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density |
title_full |
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density |
title_fullStr |
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density |
title_full_unstemmed |
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density |
title_sort |
genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density |
publisher |
BioMed Central Ltd. |
publishDate |
2010 |
url |
http://www.biomedcentral.com/1755-8794/3/9 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
http://www.biomedcentral.com/1755-8794/3/9 |
op_rights |
Copyright 2010 Biong et al; licensee BioMed Central Ltd. |
_version_ |
1766219844182605824 |