Emerging players in the initiation of eukaryotic DNA replication
Abstract Faithful duplication of the genome in eukaryotes requires ordered assembly of a multi-protein complex called the pre-replicative complex (pre-RC) prior to S phase; transition to the pre-initiation complex (pre-IC) at the beginning of DNA replication; coordinated progression of the replisome...
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ftbiomed:oai:biomedcentral.com:1747-1028-7-22 2023-05-15T17:53:48+02:00 Emerging players in the initiation of eukaryotic DNA replication Shen, Zhen Prasanth, Supriya G 2012-10-17 http://www.celldiv.com/content/7/1/22 en eng BioMed Central Ltd. http://www.celldiv.com/content/7/1/22 Copyright 2012 Shen and Prasanth; licensee BioMed Central Ltd. ORC ORCA/LRWD1 Cdt1 Geminin MCM Pre-RC Pre-IC RPC Non-coding RNA DNA replication Review 2012 ftbiomed 2012-12-16T00:58:49Z Abstract Faithful duplication of the genome in eukaryotes requires ordered assembly of a multi-protein complex called the pre-replicative complex (pre-RC) prior to S phase; transition to the pre-initiation complex (pre-IC) at the beginning of DNA replication; coordinated progression of the replisome during S phase; and well-controlled regulation of replication licensing to prevent re-replication. These events are achieved by the formation of distinct protein complexes that form in a cell cycle-dependent manner. Several components of the pre-RC and pre-IC are highly conserved across all examined eukaryotic species. Many of these proteins, in addition to their bona fide roles in DNA replication are also required for other cell cycle events including heterochromatin organization, chromosome segregation and centrosome biology. As the complexity of the genome increases dramatically from yeast to human, additional proteins have been identified in higher eukaryotes that dictate replication initiation, progression and licensing. In this review, we discuss the newly discovered components and their roles in cell cycle progression. Review Orca BioMed Central |
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BioMed Central |
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ftbiomed |
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English |
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ORC ORCA/LRWD1 Cdt1 Geminin MCM Pre-RC Pre-IC RPC Non-coding RNA DNA replication |
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ORC ORCA/LRWD1 Cdt1 Geminin MCM Pre-RC Pre-IC RPC Non-coding RNA DNA replication Shen, Zhen Prasanth, Supriya G Emerging players in the initiation of eukaryotic DNA replication |
topic_facet |
ORC ORCA/LRWD1 Cdt1 Geminin MCM Pre-RC Pre-IC RPC Non-coding RNA DNA replication |
description |
Abstract Faithful duplication of the genome in eukaryotes requires ordered assembly of a multi-protein complex called the pre-replicative complex (pre-RC) prior to S phase; transition to the pre-initiation complex (pre-IC) at the beginning of DNA replication; coordinated progression of the replisome during S phase; and well-controlled regulation of replication licensing to prevent re-replication. These events are achieved by the formation of distinct protein complexes that form in a cell cycle-dependent manner. Several components of the pre-RC and pre-IC are highly conserved across all examined eukaryotic species. Many of these proteins, in addition to their bona fide roles in DNA replication are also required for other cell cycle events including heterochromatin organization, chromosome segregation and centrosome biology. As the complexity of the genome increases dramatically from yeast to human, additional proteins have been identified in higher eukaryotes that dictate replication initiation, progression and licensing. In this review, we discuss the newly discovered components and their roles in cell cycle progression. |
format |
Review |
author |
Shen, Zhen Prasanth, Supriya G |
author_facet |
Shen, Zhen Prasanth, Supriya G |
author_sort |
Shen, Zhen |
title |
Emerging players in the initiation of eukaryotic DNA replication |
title_short |
Emerging players in the initiation of eukaryotic DNA replication |
title_full |
Emerging players in the initiation of eukaryotic DNA replication |
title_fullStr |
Emerging players in the initiation of eukaryotic DNA replication |
title_full_unstemmed |
Emerging players in the initiation of eukaryotic DNA replication |
title_sort |
emerging players in the initiation of eukaryotic dna replication |
publisher |
BioMed Central Ltd. |
publishDate |
2012 |
url |
http://www.celldiv.com/content/7/1/22 |
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Orca |
genre_facet |
Orca |
op_relation |
http://www.celldiv.com/content/7/1/22 |
op_rights |
Copyright 2012 Shen and Prasanth; licensee BioMed Central Ltd. |
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1766161499111292928 |