Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites
Abstract In this work, we study the consequences of sequence variations of the "2009 H1N1" (swine or Mexican flu) influenza A virus strain neuraminidase for drug treatment and vaccination. We find that it is phylogenetically more closely related to European H1N1 swine flu and H5N1 avian fl...
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BioMed Central Ltd.
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ftbiomed:oai:biomedcentral.com:1745-6150-4-18 2023-05-15T15:34:24+02:00 Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites Maurer-Stroh, Sebastian Ma, Jianmin Lee, Raphael Sirota, Fernanda L Eisenhaber, Frank 2009-05-20 http://www.biology-direct.com/content/4/1/18 en eng BioMed Central Ltd. http://www.biology-direct.com/content/4/1/18 Copyright 2009 Maurer-Stroh et al; licensee BioMed Central Ltd. Discovery notes 2009 ftbiomed 2009-06-26T23:19:15Z Abstract In this work, we study the consequences of sequence variations of the "2009 H1N1" (swine or Mexican flu) influenza A virus strain neuraminidase for drug treatment and vaccination. We find that it is phylogenetically more closely related to European H1N1 swine flu and H5N1 avian flu rather than to the H1N1 counterparts in the Americas. Homology-based 3D structure modeling reveals that the novel mutations are preferentially located at the protein surface and do not interfere with the active site. The latter is the binding cavity for 3 currently used neuraminidase inhibitors: oseltamivir (Tamiflu ® ), zanamivir (Relenza ® ) and peramivir; thus, the drugs should remain effective for treatment. However, the antigenic regions of the neuraminidase relevant for vaccine development, serological typing and passive antibody treatment can differ from those of previous strains and already vary among patients. Reviewers This article was reviewed by Sandor Pongor and L. Aravind. Other/Unknown Material Avian flu BioMed Central |
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BioMed Central |
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ftbiomed |
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English |
description |
Abstract In this work, we study the consequences of sequence variations of the "2009 H1N1" (swine or Mexican flu) influenza A virus strain neuraminidase for drug treatment and vaccination. We find that it is phylogenetically more closely related to European H1N1 swine flu and H5N1 avian flu rather than to the H1N1 counterparts in the Americas. Homology-based 3D structure modeling reveals that the novel mutations are preferentially located at the protein surface and do not interfere with the active site. The latter is the binding cavity for 3 currently used neuraminidase inhibitors: oseltamivir (Tamiflu ® ), zanamivir (Relenza ® ) and peramivir; thus, the drugs should remain effective for treatment. However, the antigenic regions of the neuraminidase relevant for vaccine development, serological typing and passive antibody treatment can differ from those of previous strains and already vary among patients. Reviewers This article was reviewed by Sandor Pongor and L. Aravind. |
format |
Other/Unknown Material |
author |
Maurer-Stroh, Sebastian Ma, Jianmin Lee, Raphael Sirota, Fernanda L Eisenhaber, Frank |
spellingShingle |
Maurer-Stroh, Sebastian Ma, Jianmin Lee, Raphael Sirota, Fernanda L Eisenhaber, Frank Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites |
author_facet |
Maurer-Stroh, Sebastian Ma, Jianmin Lee, Raphael Sirota, Fernanda L Eisenhaber, Frank |
author_sort |
Maurer-Stroh, Sebastian |
title |
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites |
title_short |
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites |
title_full |
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites |
title_fullStr |
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites |
title_full_unstemmed |
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites |
title_sort |
mapping the sequence mutations of the 2009 h1n1 influenza a virus neuraminidase relative to drug and antibody binding sites |
publisher |
BioMed Central Ltd. |
publishDate |
2009 |
url |
http://www.biology-direct.com/content/4/1/18 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_relation |
http://www.biology-direct.com/content/4/1/18 |
op_rights |
Copyright 2009 Maurer-Stroh et al; licensee BioMed Central Ltd. |
_version_ |
1766364814011006976 |