Xenoestrogenic activity in blood of European and Inuit populations
Abstract Background Human exposure to persistent organic pollutants (POPs) is ubiquitous and found in all individuals. Studies have documented endocrine disrupting effects and impact on reproduction. The aim of the present study was to compare the level of xenoestrogenic activity in serum of groups...
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ftbiomed:oai:biomedcentral.com:1476-069X-5-12 2023-05-15T16:31:12+02:00 Xenoestrogenic activity in blood of European and Inuit populations Bonefeld-Jorgensen, Eva C Hjelmborg, Philip S Reinert, Thayaline S Andersen, Birgitte S Lesovoy, Vladimir Lindh, Christian H Hagmar, Lars Giwercman, Aleksander Erlandsen, Mogens Manicardi, Gian-Carlo Spanò, Marcello Toft, Gunnar Bonde, Jens 2006-05-05 http://www.ehjournal.net/content/5/1/12 en eng BioMed Central Ltd. http://www.ehjournal.net/content/5/1/12 Copyright 2006 Bonefeld-Jorgensen et al; licensee BioMed Central Ltd. Research 2006 ftbiomed 2007-11-11T15:30:49Z Abstract Background Human exposure to persistent organic pollutants (POPs) is ubiquitous and found in all individuals. Studies have documented endocrine disrupting effects and impact on reproduction. The aim of the present study was to compare the level of xenoestrogenic activity in serum of groups with varying POP exposure, and to evaluate correlations to the POP biomarkers, 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis ( p -chlorophenyl)-ethylene ( p,p' -DDE). Methods The study included 358 men: Greenlandic Inuit's, Swedish fishermen, and Warsaw (Poland) and Kharkiv (Ukraine) inhabitants. Xenoestrogenicity of serum extracts alone (XER) and XER competitive (XERcomp) effect on 17β-estradiol induced estrogen receptor (ER) transactivity were assessed in the hormone free, lipophilic serum fraction containing the POPs using the MVLN human breast cancer cell line. Results No agonistic XER activity was exhibited for Inuit serum samples, while 12 – 24% of the European samples had detectable agonistic XER activity. On the contrary, 71% of Inuit serum samples antagonized XERcomp compared to 7 – 30 % in the other regions. XER and XERcomp were not or weakly correlated to the two POP markers. XER activity of Inuit samples was negatively associated to levels of CB-153 and p,p '-DDE. For the Warsaw group a positive and negative correlation between XER and p,p' -DDE and estradiol equivalence level and CB-153 levels was found. Conclusion No strong consistent association between xenoestrogenic net activity and the two POP markers was found. The results showed that the selected POP markers alone can not predict the integrated xenoestrogenic serum activity. Correlations to the POP markers were found at the extreme edge; the Inuit's and Warsaw study groups eliciting high frequency of samples with ER antagonistic and agonistic activity, respectively. We suggest that the variation in xenoestrogenic serum activity reflects differences in POP exposure mixture, genetic factors and/or life style factors. Other/Unknown Material greenlandic inuit BioMed Central |
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BioMed Central |
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ftbiomed |
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English |
description |
Abstract Background Human exposure to persistent organic pollutants (POPs) is ubiquitous and found in all individuals. Studies have documented endocrine disrupting effects and impact on reproduction. The aim of the present study was to compare the level of xenoestrogenic activity in serum of groups with varying POP exposure, and to evaluate correlations to the POP biomarkers, 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis ( p -chlorophenyl)-ethylene ( p,p' -DDE). Methods The study included 358 men: Greenlandic Inuit's, Swedish fishermen, and Warsaw (Poland) and Kharkiv (Ukraine) inhabitants. Xenoestrogenicity of serum extracts alone (XER) and XER competitive (XERcomp) effect on 17β-estradiol induced estrogen receptor (ER) transactivity were assessed in the hormone free, lipophilic serum fraction containing the POPs using the MVLN human breast cancer cell line. Results No agonistic XER activity was exhibited for Inuit serum samples, while 12 – 24% of the European samples had detectable agonistic XER activity. On the contrary, 71% of Inuit serum samples antagonized XERcomp compared to 7 – 30 % in the other regions. XER and XERcomp were not or weakly correlated to the two POP markers. XER activity of Inuit samples was negatively associated to levels of CB-153 and p,p '-DDE. For the Warsaw group a positive and negative correlation between XER and p,p' -DDE and estradiol equivalence level and CB-153 levels was found. Conclusion No strong consistent association between xenoestrogenic net activity and the two POP markers was found. The results showed that the selected POP markers alone can not predict the integrated xenoestrogenic serum activity. Correlations to the POP markers were found at the extreme edge; the Inuit's and Warsaw study groups eliciting high frequency of samples with ER antagonistic and agonistic activity, respectively. We suggest that the variation in xenoestrogenic serum activity reflects differences in POP exposure mixture, genetic factors and/or life style factors. |
format |
Other/Unknown Material |
author |
Bonefeld-Jorgensen, Eva C Hjelmborg, Philip S Reinert, Thayaline S Andersen, Birgitte S Lesovoy, Vladimir Lindh, Christian H Hagmar, Lars Giwercman, Aleksander Erlandsen, Mogens Manicardi, Gian-Carlo Spanò, Marcello Toft, Gunnar Bonde, Jens |
spellingShingle |
Bonefeld-Jorgensen, Eva C Hjelmborg, Philip S Reinert, Thayaline S Andersen, Birgitte S Lesovoy, Vladimir Lindh, Christian H Hagmar, Lars Giwercman, Aleksander Erlandsen, Mogens Manicardi, Gian-Carlo Spanò, Marcello Toft, Gunnar Bonde, Jens Xenoestrogenic activity in blood of European and Inuit populations |
author_facet |
Bonefeld-Jorgensen, Eva C Hjelmborg, Philip S Reinert, Thayaline S Andersen, Birgitte S Lesovoy, Vladimir Lindh, Christian H Hagmar, Lars Giwercman, Aleksander Erlandsen, Mogens Manicardi, Gian-Carlo Spanò, Marcello Toft, Gunnar Bonde, Jens |
author_sort |
Bonefeld-Jorgensen, Eva C |
title |
Xenoestrogenic activity in blood of European and Inuit populations |
title_short |
Xenoestrogenic activity in blood of European and Inuit populations |
title_full |
Xenoestrogenic activity in blood of European and Inuit populations |
title_fullStr |
Xenoestrogenic activity in blood of European and Inuit populations |
title_full_unstemmed |
Xenoestrogenic activity in blood of European and Inuit populations |
title_sort |
xenoestrogenic activity in blood of european and inuit populations |
publisher |
BioMed Central Ltd. |
publishDate |
2006 |
url |
http://www.ehjournal.net/content/5/1/12 |
genre |
greenlandic inuit |
genre_facet |
greenlandic inuit |
op_relation |
http://www.ehjournal.net/content/5/1/12 |
op_rights |
Copyright 2006 Bonefeld-Jorgensen et al; licensee BioMed Central Ltd. |
_version_ |
1766020966902661120 |