Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine
Abstract Background Perfluoroalkyl substances (PFAS) are suggested to affect human fecundity through longer time to pregnancy (TTP). We studied the relationship between four abundant PFAS and TTP in pregnant women from Greenland, Poland and Ukraine representing varying PFAS exposures and pregnancy p...
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ftbiomed:oai:biomedcentral.com:1476-069X-13-116 2023-05-15T16:26:18+02:00 Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine Jørgensen, Kristian T Specht, Ina O Lenters, Virissa Bach, Cathrine C Rylander, Lars Jönsson, Bo AG Lindh, Christian H Giwercman, Aleksander Heederik, Dick Toft, Gunnar Bonde, Jens 2014-12-22 http://www.ehjournal.net/content/13/1/116 en eng BioMed Central Ltd. http://www.ehjournal.net/content/13/1/116 Copyright 2014 Jørgensen et al.; licensee BioMed Central. Fecundity Perfluorinated compounds Infertility Persistent environmental pollutants Research 2014 ftbiomed 2015-03-15T00:53:50Z Abstract Background Perfluoroalkyl substances (PFAS) are suggested to affect human fecundity through longer time to pregnancy (TTP). We studied the relationship between four abundant PFAS and TTP in pregnant women from Greenland, Poland and Ukraine representing varying PFAS exposures and pregnancy planning behaviors. Methods We measured serum levels of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) in 938 women from Greenland (448 women), Poland (203 women) and Ukraine (287 women). PFAS exposure was assessed on a continuous logarithm transformed scale and in country-specific tertiles. We used Cox discrete-time models and logistic regression to estimate fecundability ratios (FRs) and infertility (TTP >13 months) odds ratios (ORs), respectively, and 95% confidence intervals (CI) according to PFAS levels. Adjusted analyses of the association between PFAS and TTP were done for each study population and in a pooled sample. Results Higher PFNA levels were associated with longer TTP in the pooled sample (log-scale FR = 0.80; 95% CI 0.69-0.94) and specifically in women from Greenland (log-scale FR = 0.72; 95% CI 0.58-0.89). ORs for infertility were also increased in the pooled sample (log-scale OR = 1.53; 95% CI 1.08-2.15) and in women from Greenland (log-scale OR = 1.97; 95% CI 1.22-3.19). However, in a sensitivity analysis of primiparous women these associations could not be replicated. Associations with PFNA were weaker for women from Poland and Ukraine. PFOS, PFOA and PFHxS were not consistently associated with TTP. Conclusions Findings do not provide consistent evidence that environmental exposure to PFAS is impairing female fecundity by delaying time taken to conceive. Other/Unknown Material Greenland BioMed Central Greenland |
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BioMed Central |
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ftbiomed |
language |
English |
topic |
Fecundity Perfluorinated compounds Infertility Persistent environmental pollutants |
spellingShingle |
Fecundity Perfluorinated compounds Infertility Persistent environmental pollutants Jørgensen, Kristian T Specht, Ina O Lenters, Virissa Bach, Cathrine C Rylander, Lars Jönsson, Bo AG Lindh, Christian H Giwercman, Aleksander Heederik, Dick Toft, Gunnar Bonde, Jens Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
topic_facet |
Fecundity Perfluorinated compounds Infertility Persistent environmental pollutants |
description |
Abstract Background Perfluoroalkyl substances (PFAS) are suggested to affect human fecundity through longer time to pregnancy (TTP). We studied the relationship between four abundant PFAS and TTP in pregnant women from Greenland, Poland and Ukraine representing varying PFAS exposures and pregnancy planning behaviors. Methods We measured serum levels of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonic acid (PFHxS) and perfluorononanoic acid (PFNA) in 938 women from Greenland (448 women), Poland (203 women) and Ukraine (287 women). PFAS exposure was assessed on a continuous logarithm transformed scale and in country-specific tertiles. We used Cox discrete-time models and logistic regression to estimate fecundability ratios (FRs) and infertility (TTP >13 months) odds ratios (ORs), respectively, and 95% confidence intervals (CI) according to PFAS levels. Adjusted analyses of the association between PFAS and TTP were done for each study population and in a pooled sample. Results Higher PFNA levels were associated with longer TTP in the pooled sample (log-scale FR = 0.80; 95% CI 0.69-0.94) and specifically in women from Greenland (log-scale FR = 0.72; 95% CI 0.58-0.89). ORs for infertility were also increased in the pooled sample (log-scale OR = 1.53; 95% CI 1.08-2.15) and in women from Greenland (log-scale OR = 1.97; 95% CI 1.22-3.19). However, in a sensitivity analysis of primiparous women these associations could not be replicated. Associations with PFNA were weaker for women from Poland and Ukraine. PFOS, PFOA and PFHxS were not consistently associated with TTP. Conclusions Findings do not provide consistent evidence that environmental exposure to PFAS is impairing female fecundity by delaying time taken to conceive. |
format |
Other/Unknown Material |
author |
Jørgensen, Kristian T Specht, Ina O Lenters, Virissa Bach, Cathrine C Rylander, Lars Jönsson, Bo AG Lindh, Christian H Giwercman, Aleksander Heederik, Dick Toft, Gunnar Bonde, Jens |
author_facet |
Jørgensen, Kristian T Specht, Ina O Lenters, Virissa Bach, Cathrine C Rylander, Lars Jönsson, Bo AG Lindh, Christian H Giwercman, Aleksander Heederik, Dick Toft, Gunnar Bonde, Jens |
author_sort |
Jørgensen, Kristian T |
title |
Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
title_short |
Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
title_full |
Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
title_fullStr |
Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
title_full_unstemmed |
Perfluoroalkyl substances and time to pregnancy in couples from Greenland, Poland and Ukraine |
title_sort |
perfluoroalkyl substances and time to pregnancy in couples from greenland, poland and ukraine |
publisher |
BioMed Central Ltd. |
publishDate |
2014 |
url |
http://www.ehjournal.net/content/13/1/116 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_relation |
http://www.ehjournal.net/content/13/1/116 |
op_rights |
Copyright 2014 Jørgensen et al.; licensee BioMed Central. |
_version_ |
1766015201998536704 |