Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study
Abstract Background Both diabetic and non-diabetic end stage renal disease (ESRD) are more common among Canadian First Nations people than among the general Canadian population. The purpose of this research was to determine the prevalence of and risk factors for albuminuria in a Canadian First Natio...
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ftbiomed:oai:biomedcentral.com:1471-2458-12-290 2023-05-15T16:17:05+02:00 Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study Zacharias, James Young, T Riediger, Natalie D Roulette, Joanne Bruce, Sharon G 2012-04-20 http://www.biomedcentral.com/1471-2458/12/290 en eng BioMed Central Ltd. http://www.biomedcentral.com/1471-2458/12/290 Copyright 2012 Zacharias et al; licensee BioMed Central Ltd. Canada First Nation Albuminuria End-stage renal disease Kidney Diabetes Research article 2012 ftbiomed 2012-07-21T23:52:44Z Abstract Background Both diabetic and non-diabetic end stage renal disease (ESRD) are more common among Canadian First Nations people than among the general Canadian population. The purpose of this research was to determine the prevalence of and risk factors for albuminuria in a Canadian First Nation population at high risk for ESRD and dialysis. Methods Data from a community-based screening study of 483 residents of a Plains Ojibway First Nation in Manitoba was used. Participants provided random urine samples. Proteinuria was defined as any dipstick positive for protein (≥1 g/L) or those with ACR in the macroalbuminuric range (≥30 mg/mmol) on at least one sample. Microalbuminuria was defined as ACR ≥2 mg/mmol for males and ≥2.8 mg/mmol for females. Other measures included fasting glucose, haemoglobin A 1c , triglycerides, cholesterol, blood pressure, height, weight and waist and hip circumferences. Results Twenty percent of study participants had albuminuria, (5% proteinuria and 15% microalbuminuria). Of participants with diabetes, 42% (56/132) had albuminuria compared to 26% (7/27) among those with impaired fasting glucose and 10% (30/303) among those with normal glucose tolerance. Only 5.3% of those with albuminuria were aware of any degree of renal disease. In a multivariate logistic regression, independent associations with albuminuria were male gender [p = 0.002], increasing fasting glucose [p <0.0001], years diagnosed with diabetes [p = 0.03], increasing systolic blood pressure [p = 0.009], and increasing body mass index (BMI) [p = 0.04]. Conclusions The independent association between BMI and albuminuria has not been previously reported among indigenous populations. There is a high prevalence of albuminuria in this Canadian First Nation population; the high proportion of patients with diabetes and undiagnosed kidney disease demonstrates the need for screening, education and intervention to halt the progression and development of albuminuria and ultimately ESRD and CVD. Article in Journal/Newspaper First Nations BioMed Central Canada |
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English |
topic |
Canada First Nation Albuminuria End-stage renal disease Kidney Diabetes |
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Canada First Nation Albuminuria End-stage renal disease Kidney Diabetes Zacharias, James Young, T Riediger, Natalie D Roulette, Joanne Bruce, Sharon G Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
topic_facet |
Canada First Nation Albuminuria End-stage renal disease Kidney Diabetes |
description |
Abstract Background Both diabetic and non-diabetic end stage renal disease (ESRD) are more common among Canadian First Nations people than among the general Canadian population. The purpose of this research was to determine the prevalence of and risk factors for albuminuria in a Canadian First Nation population at high risk for ESRD and dialysis. Methods Data from a community-based screening study of 483 residents of a Plains Ojibway First Nation in Manitoba was used. Participants provided random urine samples. Proteinuria was defined as any dipstick positive for protein (≥1 g/L) or those with ACR in the macroalbuminuric range (≥30 mg/mmol) on at least one sample. Microalbuminuria was defined as ACR ≥2 mg/mmol for males and ≥2.8 mg/mmol for females. Other measures included fasting glucose, haemoglobin A 1c , triglycerides, cholesterol, blood pressure, height, weight and waist and hip circumferences. Results Twenty percent of study participants had albuminuria, (5% proteinuria and 15% microalbuminuria). Of participants with diabetes, 42% (56/132) had albuminuria compared to 26% (7/27) among those with impaired fasting glucose and 10% (30/303) among those with normal glucose tolerance. Only 5.3% of those with albuminuria were aware of any degree of renal disease. In a multivariate logistic regression, independent associations with albuminuria were male gender [p = 0.002], increasing fasting glucose [p <0.0001], years diagnosed with diabetes [p = 0.03], increasing systolic blood pressure [p = 0.009], and increasing body mass index (BMI) [p = 0.04]. Conclusions The independent association between BMI and albuminuria has not been previously reported among indigenous populations. There is a high prevalence of albuminuria in this Canadian First Nation population; the high proportion of patients with diabetes and undiagnosed kidney disease demonstrates the need for screening, education and intervention to halt the progression and development of albuminuria and ultimately ESRD and CVD. |
format |
Article in Journal/Newspaper |
author |
Zacharias, James Young, T Riediger, Natalie D Roulette, Joanne Bruce, Sharon G |
author_facet |
Zacharias, James Young, T Riediger, Natalie D Roulette, Joanne Bruce, Sharon G |
author_sort |
Zacharias, James |
title |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_short |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_full |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_fullStr |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_full_unstemmed |
Prevalence, risk factors and awareness of albuminuria on a Canadian First Nation: A community-based screening study |
title_sort |
prevalence, risk factors and awareness of albuminuria on a canadian first nation: a community-based screening study |
publisher |
BioMed Central Ltd. |
publishDate |
2012 |
url |
http://www.biomedcentral.com/1471-2458/12/290 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
First Nations |
genre_facet |
First Nations |
op_relation |
http://www.biomedcentral.com/1471-2458/12/290 |
op_rights |
Copyright 2012 Zacharias et al; licensee BioMed Central Ltd. |
_version_ |
1766002923022581760 |