Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study
Abstract Background The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population. Adjustments for additional cardiovascular risk factors have not been consistent. We examined the association of serum uric acid with all-cause morta...
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ftbiomed:oai:biomedcentral.com:1471-2261-13-115 2023-05-15T18:34:45+02:00 Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study Storhaug, Hilde M Norvik, Jon V Toft, Ingrid Eriksen, Bjorn O Løchen, Maja-Lisa Zykova, Svetlana Solbu, Marit White, Sarah Chadban, Steve Jenssen, Trond 2013-12-11 http://www.biomedcentral.com/1471-2261/13/115 en eng BioMed Central Ltd. http://www.biomedcentral.com/1471-2261/13/115 Copyright 2013 Storhaug et al.; licensee BioMed Central Ltd. All-cause mortality Gender Myocardial infarction Stroke Uric acid Research article 2013 ftbiomed 2013-12-22T01:24:51Z Abstract Background The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population. Adjustments for additional cardiovascular risk factors have not been consistent. We examined the association of serum uric acid with all-cause mortality, ischemic stroke and myocardial infarction in a prospective population based study, with several traditional and non-traditional risk factors for cardiovascular disease included in the model. Methods A population-based prospective cohort study was performed among 2696 men and 3004 women. Endpoints were all-cause mortality after 15 years, and fatal or non-fatal myocardial infarction (MI) and ischemic stroke after 12 years. Results 1433 deaths, 659 MIs and 430 ischemic strokes occurred during follow-up. Fully adjusted Cox regression analyses showed that per 1 SD (87 μmol/L) increase in serum uric acid level, the risk of all-cause mortality increased in both genders (hazard ratios, HR men; 1.11, 95% CI 1.02-1.20, women; 1.16, 1.05-1.29). HRs and 95% CI for stroke were 1.31, 1.14-1.50 in men, 1.13, 0.94-1.36 in women, and 1.22 (1.09, 1.35) in the overall population. No independent associations were observed with MI. Conclusion Serum uric acid was associated with all-cause mortality in men and women, even after adjustment for blood pressure, estimated GFR, urinary albumin/creatinine ratio, drug intake and traditional cardiovascular risk factors. After the same adjustments, serum uric acid was associated with 31% increased risk of stroke in men. Article in Journal/Newspaper Tromsø BioMed Central Tromsø |
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BioMed Central |
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ftbiomed |
language |
English |
topic |
All-cause mortality Gender Myocardial infarction Stroke Uric acid |
spellingShingle |
All-cause mortality Gender Myocardial infarction Stroke Uric acid Storhaug, Hilde M Norvik, Jon V Toft, Ingrid Eriksen, Bjorn O Løchen, Maja-Lisa Zykova, Svetlana Solbu, Marit White, Sarah Chadban, Steve Jenssen, Trond Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study |
topic_facet |
All-cause mortality Gender Myocardial infarction Stroke Uric acid |
description |
Abstract Background The role of serum uric acid as an independent predictor of cardiovascular disease and death is uncertain in the general population. Adjustments for additional cardiovascular risk factors have not been consistent. We examined the association of serum uric acid with all-cause mortality, ischemic stroke and myocardial infarction in a prospective population based study, with several traditional and non-traditional risk factors for cardiovascular disease included in the model. Methods A population-based prospective cohort study was performed among 2696 men and 3004 women. Endpoints were all-cause mortality after 15 years, and fatal or non-fatal myocardial infarction (MI) and ischemic stroke after 12 years. Results 1433 deaths, 659 MIs and 430 ischemic strokes occurred during follow-up. Fully adjusted Cox regression analyses showed that per 1 SD (87 μmol/L) increase in serum uric acid level, the risk of all-cause mortality increased in both genders (hazard ratios, HR men; 1.11, 95% CI 1.02-1.20, women; 1.16, 1.05-1.29). HRs and 95% CI for stroke were 1.31, 1.14-1.50 in men, 1.13, 0.94-1.36 in women, and 1.22 (1.09, 1.35) in the overall population. No independent associations were observed with MI. Conclusion Serum uric acid was associated with all-cause mortality in men and women, even after adjustment for blood pressure, estimated GFR, urinary albumin/creatinine ratio, drug intake and traditional cardiovascular risk factors. After the same adjustments, serum uric acid was associated with 31% increased risk of stroke in men. |
format |
Article in Journal/Newspaper |
author |
Storhaug, Hilde M Norvik, Jon V Toft, Ingrid Eriksen, Bjorn O Løchen, Maja-Lisa Zykova, Svetlana Solbu, Marit White, Sarah Chadban, Steve Jenssen, Trond |
author_facet |
Storhaug, Hilde M Norvik, Jon V Toft, Ingrid Eriksen, Bjorn O Løchen, Maja-Lisa Zykova, Svetlana Solbu, Marit White, Sarah Chadban, Steve Jenssen, Trond |
author_sort |
Storhaug, Hilde M |
title |
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study |
title_short |
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study |
title_full |
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study |
title_fullStr |
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study |
title_full_unstemmed |
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study |
title_sort |
uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from the tromsø study |
publisher |
BioMed Central Ltd. |
publishDate |
2013 |
url |
http://www.biomedcentral.com/1471-2261/13/115 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
http://www.biomedcentral.com/1471-2261/13/115 |
op_rights |
Copyright 2013 Storhaug et al.; licensee BioMed Central Ltd. |
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1766219659399397376 |