Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits
Abstract Background Low vitamin D status has been shown to be a risk factor for several metabolic traits such as obesity, diabetes and cardiovascular disease. The biological actions of 1, 25-dihydroxyvitamin D, are mediated through the vitamin D receptor (VDR), which heterodimerizes with retinoid X...
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ftbiomed:oai:biomedcentral.com:1471-2156-15-37 2023-05-15T17:42:49+02:00 Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits Vimaleswaran, Karani S Cavadino, Alana Berry, Diane J Mangino, Massimo Andrews, Peter Moore, Jason H Spector, Timothy D Power, Chris Järvelin, Marjo-Riitta Hyppönen, Elina 2014-03-19 http://www.biomedcentral.com/1471-2156/15/37 en eng BioMed Central Ltd. http://www.biomedcentral.com/1471-2156/15/37 Copyright 2014 Vimaleswaran et al.; licensee BioMed Central Ltd. VDR RXRG SNPs SNP-SNP interaction 1958BC Research article 2014 ftbiomed 2014-03-30T01:28:19Z Abstract Background Low vitamin D status has been shown to be a risk factor for several metabolic traits such as obesity, diabetes and cardiovascular disease. The biological actions of 1, 25-dihydroxyvitamin D, are mediated through the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptor, gamma (RXRG). Hence, we examined the potential interactions between the tagging polymorphisms in the VDR (22 tag SNPs) and RXRG (23 tag SNPs) genes on metabolic outcomes such as body mass index, waist circumference, waist-hip ratio (WHR), high- and low-density lipoprotein (LDL) cholesterols, serum triglycerides, systolic and diastolic blood pressures and glycated haemoglobin in the 1958 British Birth Cohort (1958BC, up to n = 5,231). We used Multifactor- dimensionality reduction (MDR) program as a non-parametric test to examine for potential interactions between the VDR and RXRG gene polymorphisms in the 1958BC. We used the data from Northern Finland Birth Cohort 1966 (NFBC66, up to n = 5,316) and Twins UK (up to n = 3,943) to replicate our initial findings from 1958BC. Results After Bonferroni correction, the joint-likelihood ratio test suggested interactions on serum triglycerides (4 SNP - SNP pairs), LDL cholesterol (2 SNP - SNP pairs) and WHR (1 SNP - SNP pair) in the 1958BC. MDR permutation model testing analysis showed one two-way and one three-way interaction to be statistically significant on serum triglycerides in the 1958BC. In meta-analysis of results from two replication cohorts (NFBC66 and Twins UK, total n = 8,183), none of the interactions remained after correction for multiple testing (P interaction >0.17). Conclusions Our results did not provide strong evidence for interactions between allelic variations in VDR and RXRG genes on metabolic outcomes; however, further replication studies on large samples are needed to confirm our findings. Article in Journal/Newspaper Northern Finland BioMed Central |
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BioMed Central |
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ftbiomed |
language |
English |
topic |
VDR RXRG SNPs SNP-SNP interaction 1958BC |
spellingShingle |
VDR RXRG SNPs SNP-SNP interaction 1958BC Vimaleswaran, Karani S Cavadino, Alana Berry, Diane J Mangino, Massimo Andrews, Peter Moore, Jason H Spector, Timothy D Power, Chris Järvelin, Marjo-Riitta Hyppönen, Elina Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits |
topic_facet |
VDR RXRG SNPs SNP-SNP interaction 1958BC |
description |
Abstract Background Low vitamin D status has been shown to be a risk factor for several metabolic traits such as obesity, diabetes and cardiovascular disease. The biological actions of 1, 25-dihydroxyvitamin D, are mediated through the vitamin D receptor (VDR), which heterodimerizes with retinoid X receptor, gamma (RXRG). Hence, we examined the potential interactions between the tagging polymorphisms in the VDR (22 tag SNPs) and RXRG (23 tag SNPs) genes on metabolic outcomes such as body mass index, waist circumference, waist-hip ratio (WHR), high- and low-density lipoprotein (LDL) cholesterols, serum triglycerides, systolic and diastolic blood pressures and glycated haemoglobin in the 1958 British Birth Cohort (1958BC, up to n = 5,231). We used Multifactor- dimensionality reduction (MDR) program as a non-parametric test to examine for potential interactions between the VDR and RXRG gene polymorphisms in the 1958BC. We used the data from Northern Finland Birth Cohort 1966 (NFBC66, up to n = 5,316) and Twins UK (up to n = 3,943) to replicate our initial findings from 1958BC. Results After Bonferroni correction, the joint-likelihood ratio test suggested interactions on serum triglycerides (4 SNP - SNP pairs), LDL cholesterol (2 SNP - SNP pairs) and WHR (1 SNP - SNP pair) in the 1958BC. MDR permutation model testing analysis showed one two-way and one three-way interaction to be statistically significant on serum triglycerides in the 1958BC. In meta-analysis of results from two replication cohorts (NFBC66 and Twins UK, total n = 8,183), none of the interactions remained after correction for multiple testing (P interaction >0.17). Conclusions Our results did not provide strong evidence for interactions between allelic variations in VDR and RXRG genes on metabolic outcomes; however, further replication studies on large samples are needed to confirm our findings. |
format |
Article in Journal/Newspaper |
author |
Vimaleswaran, Karani S Cavadino, Alana Berry, Diane J Mangino, Massimo Andrews, Peter Moore, Jason H Spector, Timothy D Power, Chris Järvelin, Marjo-Riitta Hyppönen, Elina |
author_facet |
Vimaleswaran, Karani S Cavadino, Alana Berry, Diane J Mangino, Massimo Andrews, Peter Moore, Jason H Spector, Timothy D Power, Chris Järvelin, Marjo-Riitta Hyppönen, Elina |
author_sort |
Vimaleswaran, Karani S |
title |
Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits |
title_short |
Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits |
title_full |
Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits |
title_fullStr |
Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits |
title_full_unstemmed |
Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits |
title_sort |
interaction between allelic variations in vitamin d receptor and retinoid x receptor genes on metabolic traits |
publisher |
BioMed Central Ltd. |
publishDate |
2014 |
url |
http://www.biomedcentral.com/1471-2156/15/37 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
http://www.biomedcentral.com/1471-2156/15/37 |
op_rights |
Copyright 2014 Vimaleswaran et al.; licensee BioMed Central Ltd. |
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1766144745193603072 |