The conserved Phe GH5 of importance for hemoglobin intersubunit contact is mutated in gadoid fish

• Main Authors: Andersen, Øivind, De Rosa, Maria, Yadav, Prakash, Pirolli, Davide, Fernandes, Jorge MO, Berg, Paul R, Jentoft, Sissel, Andrè, Carl
• Format: Article in Journal/Newspaper
• Language: English
• Published: BioMed Central Ltd. 2014
• Subjects: Atlantic cod; Hemoglobin; Polymorphism; Coelacanth; Spotted gar; Positive selection; Gar’; atlantic cod; Burbot; Northeast Atlantic; Northwest Atlantic
• Online Access: http://www.biomedcentral.com/1471-2148/14/54

Abstract Background Functionality of the tetrameric hemoglobin molecule seems to be determined by a few amino acids located in key positions. Oxygen binding encompasses structural changes at the interfaces between the α1β2 and α2β1 dimers, but also subunit interactions are important for the oxygen b...