Integrated assessment of predicted MHC binding and cross-conservation with self reveals patterns of viral camouflage

• Main Authors: He, Lu, De Groot, Anne S, Gutierrez, Andres H, Martin, William D, Moise, Lenny, Bailey-Kellogg, Chris
• Format: Other/Unknown Material
• Language: English
• Published: BioMed Central Ltd. 2014
• Subjects: Janus; Avian flu
• Online Access: http://www.biomedcentral.com/1471-2105/15/S4/S1

Abstract Background Immune recognition of foreign proteins by T cells hinges on the formation of a ternary complex sandwiching a constituent peptide of the protein between a major histocompatibility complex (MHC) molecule and a T cell receptor (TCR). Viruses have evolved means of "camouflaging&...