Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu.
Chickens suffering from avian flu caused by H5N1 influenza virus are destined to die within 2 days due to a systemic inflammatory response. Since HVJ infection (1,2) and influenza virus infection (3,4) cause infected cells to activate homologous serum complement, the systemic inflammatory response e...
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2010
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ftbbaunivipb:oai:repository.ipb.ac.id:123456789/28373 2023-05-15T15:34:18+02:00 Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu. Okada, Noriko Tsukamoto, Yasuhiro Adachi, Kazuhide Handharyani, Ekowati Soejoedono, Retno Damajanti Imai, Masaki Okada, Alan Okada, Hidechika 2010 http://repository.ipb.ac.id/handle/123456789/28373 unknown IPB (Bogor Agricultural University) http://repository.ipb.ac.id/handle/123456789/28373 2010 ftbbaunivipb 2011-09-02T09:55:51Z Chickens suffering from avian flu caused by H5N1 influenza virus are destined to die within 2 days due to a systemic inflammatory response. Since HVJ infection (1,2) and influenza virus infection (3,4) cause infected cells to activate homologous serum complement, the systemic inflammatory response elicited could be attributed to the unlimited generation of C5a anaphylatoxin of the complement system, which is a causative peptide of serious inflammation. In monkeys inoculated with a lethal dose of LPS (4 mg/kg body weight), inhibition of C5a by an inhibitory peptide termed AcPepA (5) rescued these animals from serious septic shock which would have resulted in death within a day (6). Therefore, we tested whether AcPepA could also have a beneficial effect on chickens with bird flu. On another front, enhanced production of endothelin-1 (ET-1) and the activation of mast cells (MCs) have been implicated in granulocyte sequestration (7). An endothelin receptor derived antisense homology box peptide (8) designated ETR-P1/fl was shown to antagonize endothelin A receptor (ET-A receptor) (9) and reduce such inflammatory responses as endotoxin-shock (10) and hemorrhagic shock (11), thereby suppressing histamine release in the circulation (12). Thus, we also administered ETR-P1/fl to bird flu chickens expecting suppression of a systemic inflammatory response. Other/Unknown Material Avian flu Bogor Agricultural University: IPB Scientific Repository (Institut Pertanian Bogoar) |
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Bogor Agricultural University: IPB Scientific Repository (Institut Pertanian Bogoar) |
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Chickens suffering from avian flu caused by H5N1 influenza virus are destined to die within 2 days due to a systemic inflammatory response. Since HVJ infection (1,2) and influenza virus infection (3,4) cause infected cells to activate homologous serum complement, the systemic inflammatory response elicited could be attributed to the unlimited generation of C5a anaphylatoxin of the complement system, which is a causative peptide of serious inflammation. In monkeys inoculated with a lethal dose of LPS (4 mg/kg body weight), inhibition of C5a by an inhibitory peptide termed AcPepA (5) rescued these animals from serious septic shock which would have resulted in death within a day (6). Therefore, we tested whether AcPepA could also have a beneficial effect on chickens with bird flu. On another front, enhanced production of endothelin-1 (ET-1) and the activation of mast cells (MCs) have been implicated in granulocyte sequestration (7). An endothelin receptor derived antisense homology box peptide (8) designated ETR-P1/fl was shown to antagonize endothelin A receptor (ET-A receptor) (9) and reduce such inflammatory responses as endotoxin-shock (10) and hemorrhagic shock (11), thereby suppressing histamine release in the circulation (12). Thus, we also administered ETR-P1/fl to bird flu chickens expecting suppression of a systemic inflammatory response. |
author |
Okada, Noriko Tsukamoto, Yasuhiro Adachi, Kazuhide Handharyani, Ekowati Soejoedono, Retno Damajanti Imai, Masaki Okada, Alan Okada, Hidechika |
spellingShingle |
Okada, Noriko Tsukamoto, Yasuhiro Adachi, Kazuhide Handharyani, Ekowati Soejoedono, Retno Damajanti Imai, Masaki Okada, Alan Okada, Hidechika Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu. |
author_facet |
Okada, Noriko Tsukamoto, Yasuhiro Adachi, Kazuhide Handharyani, Ekowati Soejoedono, Retno Damajanti Imai, Masaki Okada, Alan Okada, Hidechika |
author_sort |
Okada, Noriko |
title |
Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu. |
title_short |
Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu. |
title_full |
Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu. |
title_fullStr |
Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu. |
title_full_unstemmed |
Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu. |
title_sort |
rescue with an anti-inflammatory peptide of chickens infected h5n1 avian flu. |
publisher |
IPB (Bogor Agricultural University) |
publishDate |
2010 |
url |
http://repository.ipb.ac.id/handle/123456789/28373 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_relation |
http://repository.ipb.ac.id/handle/123456789/28373 |
_version_ |
1766364749987053568 |