Enzyme-catalyzed resolution of aromatic ring fused cyclic tertiary alcohols

WOS:000263218600013 An efficient chemoenzymatic route for the synthesis of optically active aromatic ring fused cyclic tertiary alcohols (S)-(-)-1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol (-)-1b and (S)-(+)-1-methyl-2,3-dihydro-1H-inden-1-ol (+)-1a has been developed. Different lipases have been tes...

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Published in:Tetrahedron: Asymmetry
Main Authors: Özdemirhan, Devrim, Sezer, Serdar, Sönmez, Yasemin
Other Authors: BAİBÜ, Fen Edebiyat Fakültesi, Kimya Bölümü
Format: Article in Journal/Newspaper
Language:English
Published: Pergamon-Elsevier Science Ltd 2008
Subjects:
Fused Cyclic Tertiary Alcohols
Antarc*
Antarctica
Online Access:https://hdl.handle.net/20.500.12491/6194
https://doi.org/10.1016/j.tetasy.2008.12.002
id ftbaibuniv:oai:acikerisim.ibu.edu.tr:20.500.12491/6194
record_format openpolar
spelling ftbaibuniv:oai:acikerisim.ibu.edu.tr:20.500.12491/6194 2023-07-02T03:30:41+02:00 Enzyme-catalyzed resolution of aromatic ring fused cyclic tertiary alcohols Özdemirhan, Devrim Sezer, Serdar Sönmez, Yasemin BAİBÜ, Fen Edebiyat Fakültesi, Kimya Bölümü Özdemirhan, Devrim Sönmez, Yasemin 2008 application/pdf https://hdl.handle.net/20.500.12491/6194 https://doi.org/10.1016/j.tetasy.2008.12.002 eng eng Pergamon-Elsevier Science Ltd Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı Tetrahedron-Asymmetry 0957-4166 https://doi.org/10.1016/j.tetasy.2008.12.002 https://hdl.handle.net/20.500.12491/6194 doi:10.1016/j.tetasy.2008.12.002 19 23 2717 2720 info:eu-repo/semantics/closedAccess Fused Cyclic Tertiary Alcohols article 2008 ftbaibuniv https://doi.org/20.500.12491/619410.1016/j.tetasy.2008.12.002 2023-06-13T16:10:47Z WOS:000263218600013 An efficient chemoenzymatic route for the synthesis of optically active aromatic ring fused cyclic tertiary alcohols (S)-(-)-1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol (-)-1b and (S)-(+)-1-methyl-2,3-dihydro-1H-inden-1-ol (+)-1a has been developed. Different lipases have been tested in the transesterification of these tertiary alcohols; CAL-A (Candida antarctica Lipase A) was found to be the best biocatalyst for 1b and CAL-A-CLEA (Lipase A, C. antarctica, cross-linked enzyme aggregate) for la, obtained with ee values of 20% and 45%, respectively, and the corresponding esters 2b and 2a with the ee values of 99% and 71%, respectively. (C) 2008 Elsevier Ltd. All rights reserved. Article in Journal/Newspaper Antarc* Antarctica Bolu Abant İzzet Baysal University Institutional Repository Tetrahedron: Asymmetry 19 23 2717 2720
institution Open Polar
collection Bolu Abant İzzet Baysal University Institutional Repository
op_collection_id ftbaibuniv
language English
topic Fused Cyclic Tertiary Alcohols
spellingShingle Fused Cyclic Tertiary Alcohols
Özdemirhan, Devrim
Sezer, Serdar
Sönmez, Yasemin
Enzyme-catalyzed resolution of aromatic ring fused cyclic tertiary alcohols
topic_facet Fused Cyclic Tertiary Alcohols
description WOS:000263218600013 An efficient chemoenzymatic route for the synthesis of optically active aromatic ring fused cyclic tertiary alcohols (S)-(-)-1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol (-)-1b and (S)-(+)-1-methyl-2,3-dihydro-1H-inden-1-ol (+)-1a has been developed. Different lipases have been tested in the transesterification of these tertiary alcohols; CAL-A (Candida antarctica Lipase A) was found to be the best biocatalyst for 1b and CAL-A-CLEA (Lipase A, C. antarctica, cross-linked enzyme aggregate) for la, obtained with ee values of 20% and 45%, respectively, and the corresponding esters 2b and 2a with the ee values of 99% and 71%, respectively. (C) 2008 Elsevier Ltd. All rights reserved.
author2 BAİBÜ, Fen Edebiyat Fakültesi, Kimya Bölümü
Özdemirhan, Devrim
Sönmez, Yasemin
format Article in Journal/Newspaper
author Özdemirhan, Devrim
Sezer, Serdar
Sönmez, Yasemin
author_facet Özdemirhan, Devrim
Sezer, Serdar
Sönmez, Yasemin
author_sort Özdemirhan, Devrim
title Enzyme-catalyzed resolution of aromatic ring fused cyclic tertiary alcohols
title_short Enzyme-catalyzed resolution of aromatic ring fused cyclic tertiary alcohols
title_full Enzyme-catalyzed resolution of aromatic ring fused cyclic tertiary alcohols
title_fullStr Enzyme-catalyzed resolution of aromatic ring fused cyclic tertiary alcohols
title_full_unstemmed Enzyme-catalyzed resolution of aromatic ring fused cyclic tertiary alcohols
title_sort enzyme-catalyzed resolution of aromatic ring fused cyclic tertiary alcohols
publisher Pergamon-Elsevier Science Ltd
publishDate 2008
url https://hdl.handle.net/20.500.12491/6194
https://doi.org/10.1016/j.tetasy.2008.12.002
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_relation Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
Tetrahedron-Asymmetry
0957-4166
https://doi.org/10.1016/j.tetasy.2008.12.002
https://hdl.handle.net/20.500.12491/6194
doi:10.1016/j.tetasy.2008.12.002
19
23
2717
2720
op_rights info:eu-repo/semantics/closedAccess
op_doi https://doi.org/20.500.12491/619410.1016/j.tetasy.2008.12.002
container_title Tetrahedron: Asymmetry
container_volume 19
container_issue 23
container_start_page 2717
op_container_end_page 2720
_version_ 1770274930076680192

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