Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica
The shortening of telomeres as a causative factor in ageing is a widely discussed hypothesis in ageing research. The study of telomere length and its regenerating enzyme telomerase in the longest-lived non-colonial animal on earth, Arctica islandica, should inform whether the maintenance of telomere...
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ftawi:oai:epic.awi.de:34993 2024-09-15T17:54:28+00:00 Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica Gruber, Heike Schaible, Ralf Ridgway, Iain D. Chow, Tracy T. Held, Christoph Philipp, Eva E.R. 2014-03 application/pdf https://epic.awi.de/id/eprint/34993/ https://epic.awi.de/id/eprint/34993/1/Gruber.pdf http://www.sciencedirect.com/science/article/pii/S0531556513003707 https://hdl.handle.net/10013/epic.43114 https://hdl.handle.net/10013/epic.43114.d001 unknown Elsevier https://epic.awi.de/id/eprint/34993/1/Gruber.pdf https://hdl.handle.net/10013/epic.43114.d001 Gruber, H. , Schaible, R. , Ridgway, I. D. , Chow, T. T. , Held, C. orcid:0000-0001-8854-3234 and Philipp, E. E. (2014) Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica , Experimental Gerontology, 51 , pp. 38-45 . doi:10.1016/j.exger.2013.12.014 <https://doi.org/10.1016/j.exger.2013.12.014> , hdl:10013/epic.43114 EPIC3Experimental Gerontology, Elsevier, 51, pp. 38-45, ISSN: 0531-5565 Article isiRev 2014 ftawi https://doi.org/10.1016/j.exger.2013.12.014 2024-06-24T04:08:32Z The shortening of telomeres as a causative factor in ageing is a widely discussed hypothesis in ageing research. The study of telomere length and its regenerating enzyme telomerase in the longest-lived non-colonial animal on earth, Arctica islandica, should inform whether the maintenance of telomere length plays a role in reaching the extreme maximum lifespan (MLSP) of > 500 years in this species. Since longitudinal measurements on living animals cannot be achieved, a cross-sectional analysis of a short-lived (MLSP 40 years from the Baltic Sea) and a long-lived population (MLSP 226 years Northeast of Iceland) and in different tissues of young and old animals from the Irish Sea was performed. A high heterogeneity of telomere length was observed in investigated A. islandica over a wide age range (10–36 years for the Baltic Sea, 11–194 years for Irish Sea, 6–226 years for Iceland). Constant telomerase activity and telomere lengths were detected at any age and in different tissues; neither correlated with age or population habitat. Stable telomere maintenance might contribute to the long lifespan of A. islandica. Telomere dynamics are no explanation for the distinct MLSPs of the examined populations and thus the cause of it remains to be investigated. Article in Journal/Newspaper Arctica islandica Iceland Alfred Wegener Institute for Polar- and Marine Research (AWI): ePIC (electronic Publication Information Center) Experimental Gerontology 51 38 45 |
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Alfred Wegener Institute for Polar- and Marine Research (AWI): ePIC (electronic Publication Information Center) |
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ftawi |
language |
unknown |
description |
The shortening of telomeres as a causative factor in ageing is a widely discussed hypothesis in ageing research. The study of telomere length and its regenerating enzyme telomerase in the longest-lived non-colonial animal on earth, Arctica islandica, should inform whether the maintenance of telomere length plays a role in reaching the extreme maximum lifespan (MLSP) of > 500 years in this species. Since longitudinal measurements on living animals cannot be achieved, a cross-sectional analysis of a short-lived (MLSP 40 years from the Baltic Sea) and a long-lived population (MLSP 226 years Northeast of Iceland) and in different tissues of young and old animals from the Irish Sea was performed. A high heterogeneity of telomere length was observed in investigated A. islandica over a wide age range (10–36 years for the Baltic Sea, 11–194 years for Irish Sea, 6–226 years for Iceland). Constant telomerase activity and telomere lengths were detected at any age and in different tissues; neither correlated with age or population habitat. Stable telomere maintenance might contribute to the long lifespan of A. islandica. Telomere dynamics are no explanation for the distinct MLSPs of the examined populations and thus the cause of it remains to be investigated. |
format |
Article in Journal/Newspaper |
author |
Gruber, Heike Schaible, Ralf Ridgway, Iain D. Chow, Tracy T. Held, Christoph Philipp, Eva E.R. |
spellingShingle |
Gruber, Heike Schaible, Ralf Ridgway, Iain D. Chow, Tracy T. Held, Christoph Philipp, Eva E.R. Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica |
author_facet |
Gruber, Heike Schaible, Ralf Ridgway, Iain D. Chow, Tracy T. Held, Christoph Philipp, Eva E.R. |
author_sort |
Gruber, Heike |
title |
Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica |
title_short |
Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica |
title_full |
Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica |
title_fullStr |
Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica |
title_full_unstemmed |
Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica |
title_sort |
telomere-independent ageing in the longest-lived non-colonial animal, arctica islandica |
publisher |
Elsevier |
publishDate |
2014 |
url |
https://epic.awi.de/id/eprint/34993/ https://epic.awi.de/id/eprint/34993/1/Gruber.pdf http://www.sciencedirect.com/science/article/pii/S0531556513003707 https://hdl.handle.net/10013/epic.43114 https://hdl.handle.net/10013/epic.43114.d001 |
genre |
Arctica islandica Iceland |
genre_facet |
Arctica islandica Iceland |
op_source |
EPIC3Experimental Gerontology, Elsevier, 51, pp. 38-45, ISSN: 0531-5565 |
op_relation |
https://epic.awi.de/id/eprint/34993/1/Gruber.pdf https://hdl.handle.net/10013/epic.43114.d001 Gruber, H. , Schaible, R. , Ridgway, I. D. , Chow, T. T. , Held, C. orcid:0000-0001-8854-3234 and Philipp, E. E. (2014) Telomere-independent ageing in the longest-lived non-colonial animal, Arctica islandica , Experimental Gerontology, 51 , pp. 38-45 . doi:10.1016/j.exger.2013.12.014 <https://doi.org/10.1016/j.exger.2013.12.014> , hdl:10013/epic.43114 |
op_doi |
https://doi.org/10.1016/j.exger.2013.12.014 |
container_title |
Experimental Gerontology |
container_volume |
51 |
container_start_page |
38 |
op_container_end_page |
45 |
_version_ |
1810430783247089664 |