Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures
Summary The risk of a recurrent fragility fracture is particularly high immediately following the fracture. This study provides adjustments to FRAX-based fracture probabilities accounting for the site of a recent fracture. Introduction The recency of prior fractures affects subsequent fracture risk....
Published in: | Osteoporosis International |
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Main Authors: | , , , , , , , , , |
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Springer
2020
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Online Access: | https://acuresearchbank.acu.edu.au/download/0d43cdb9d0d29e89abcb4a7e8c521ef2063957d58893458bc326b55a7bb0b575/1036054/AM_Kanis_2020_Adjusting_conventional_FRAX_estimates_of_fracture.pdf https://doi.org/10.1007/s00198-020-05517-7 |
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ftaustraliancuni:oai:acuresearchbank.acu.edu.au:8w1vq 2023-09-05T13:20:36+02:00 Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures Kanis, J. A. Johansson, H. Harvey, N. C. Gudnason, V. Sigurdsson, G. Siggeirsdottir, K. Lorentzon, M. Liu, E. Vandenput, L. McCloskey, E. V. 2020 application/pdf https://acuresearchbank.acu.edu.au/download/0d43cdb9d0d29e89abcb4a7e8c521ef2063957d58893458bc326b55a7bb0b575/1036054/AM_Kanis_2020_Adjusting_conventional_FRAX_estimates_of_fracture.pdf https://doi.org/10.1007/s00198-020-05517-7 unknown Springer https://acuresearchbank.acu.edu.au/item/8w1vq/adjusting-conventional-frax-estimates-of-fracture-probability-according-to-the-recency-of-sentinel-fractures ISSN:0937-941X https://acuresearchbank.acu.edu.au/download/0d43cdb9d0d29e89abcb4a7e8c521ef2063957d58893458bc326b55a7bb0b575/1036054/AM_Kanis_2020_Adjusting_conventional_FRAX_estimates_of_fracture.pdf https://doi.org/10.1007/s00198-020-05517-7 Kanis, J. A., Johansson, H., Harvey, N. C., Gudnason, V., Sigurdsson, G., Siggeirsdottir, K., Lorentzon, M., Liu, E., Vandenput, L. and McCloskey, E. V. (2020). Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures. Osteoporosis International. 31(10), pp. 1817-1828. https://doi.org/10.1007/s00198-020-05517-7 All rights reserved fracture probability FRAX adjustment imminent risk prior fracture risk assessment sentinel fracture journal-article 2020 ftaustraliancuni https://doi.org/10.1007/s00198-020-05517-7 2023-08-11T14:19:40Z Summary The risk of a recurrent fragility fracture is particularly high immediately following the fracture. This study provides adjustments to FRAX-based fracture probabilities accounting for the site of a recent fracture. Introduction The recency of prior fractures affects subsequent fracture risk. The aim of this study was to quantify the effect of a recent sentinel fracture, by site, on the 10-year probability of fracture determined with FRAX. Methods The study used data from the Reykjavik Study fracture register that documented prospectively all fractures at all skeletal sites in a large sample of the population of Iceland. Fracture probabilities were determined after a sentinel fracture (humeral, clinical vertebral, forearm and hip fracture) from the hazards of death and fracture. Fracture probabilities were computed on the one hand for sentinel fractures occurring within the previous 2 years and on the other hand, probabilities for a prior osteoporotic fracture irrespective of recency. The probability ratios provided adjustments to conventional FRAX estimates of fracture probability for recent sentinel fractures. Results Probability ratios to adjust 10-year FRAX probabilities of a major osteoporotic fracture for recent sentinel fractures were age dependent, decreasing with age in both men and women. Probability ratios varied according to the site of sentinel fracture with higher ratios for hip and vertebral fracture than for humerus or forearm fracture. Probability ratios to adjust 10-year FRAX probabilities of a hip fracture for recent sentinel fractures were also age dependent, decreasing with age in both men and women with the exception of forearm fractures. Conclusion The probability ratios provide adjustments to conventional FRAX estimates of fracture probability for recent sentinel fractures. Article in Journal/Newspaper Iceland Australian Catholic University: ACU Research Bank Osteoporosis International 31 10 1817 1828 |
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Open Polar |
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Australian Catholic University: ACU Research Bank |
op_collection_id |
ftaustraliancuni |
language |
unknown |
topic |
fracture probability FRAX adjustment imminent risk prior fracture risk assessment sentinel fracture |
spellingShingle |
fracture probability FRAX adjustment imminent risk prior fracture risk assessment sentinel fracture Kanis, J. A. Johansson, H. Harvey, N. C. Gudnason, V. Sigurdsson, G. Siggeirsdottir, K. Lorentzon, M. Liu, E. Vandenput, L. McCloskey, E. V. Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures |
topic_facet |
fracture probability FRAX adjustment imminent risk prior fracture risk assessment sentinel fracture |
description |
Summary The risk of a recurrent fragility fracture is particularly high immediately following the fracture. This study provides adjustments to FRAX-based fracture probabilities accounting for the site of a recent fracture. Introduction The recency of prior fractures affects subsequent fracture risk. The aim of this study was to quantify the effect of a recent sentinel fracture, by site, on the 10-year probability of fracture determined with FRAX. Methods The study used data from the Reykjavik Study fracture register that documented prospectively all fractures at all skeletal sites in a large sample of the population of Iceland. Fracture probabilities were determined after a sentinel fracture (humeral, clinical vertebral, forearm and hip fracture) from the hazards of death and fracture. Fracture probabilities were computed on the one hand for sentinel fractures occurring within the previous 2 years and on the other hand, probabilities for a prior osteoporotic fracture irrespective of recency. The probability ratios provided adjustments to conventional FRAX estimates of fracture probability for recent sentinel fractures. Results Probability ratios to adjust 10-year FRAX probabilities of a major osteoporotic fracture for recent sentinel fractures were age dependent, decreasing with age in both men and women. Probability ratios varied according to the site of sentinel fracture with higher ratios for hip and vertebral fracture than for humerus or forearm fracture. Probability ratios to adjust 10-year FRAX probabilities of a hip fracture for recent sentinel fractures were also age dependent, decreasing with age in both men and women with the exception of forearm fractures. Conclusion The probability ratios provide adjustments to conventional FRAX estimates of fracture probability for recent sentinel fractures. |
format |
Article in Journal/Newspaper |
author |
Kanis, J. A. Johansson, H. Harvey, N. C. Gudnason, V. Sigurdsson, G. Siggeirsdottir, K. Lorentzon, M. Liu, E. Vandenput, L. McCloskey, E. V. |
author_facet |
Kanis, J. A. Johansson, H. Harvey, N. C. Gudnason, V. Sigurdsson, G. Siggeirsdottir, K. Lorentzon, M. Liu, E. Vandenput, L. McCloskey, E. V. |
author_sort |
Kanis, J. A. |
title |
Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures |
title_short |
Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures |
title_full |
Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures |
title_fullStr |
Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures |
title_full_unstemmed |
Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures |
title_sort |
adjusting conventional frax estimates of fracture probability according to the recency of sentinel fractures |
publisher |
Springer |
publishDate |
2020 |
url |
https://acuresearchbank.acu.edu.au/download/0d43cdb9d0d29e89abcb4a7e8c521ef2063957d58893458bc326b55a7bb0b575/1036054/AM_Kanis_2020_Adjusting_conventional_FRAX_estimates_of_fracture.pdf https://doi.org/10.1007/s00198-020-05517-7 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
https://acuresearchbank.acu.edu.au/item/8w1vq/adjusting-conventional-frax-estimates-of-fracture-probability-according-to-the-recency-of-sentinel-fractures ISSN:0937-941X https://acuresearchbank.acu.edu.au/download/0d43cdb9d0d29e89abcb4a7e8c521ef2063957d58893458bc326b55a7bb0b575/1036054/AM_Kanis_2020_Adjusting_conventional_FRAX_estimates_of_fracture.pdf https://doi.org/10.1007/s00198-020-05517-7 Kanis, J. A., Johansson, H., Harvey, N. C., Gudnason, V., Sigurdsson, G., Siggeirsdottir, K., Lorentzon, M., Liu, E., Vandenput, L. and McCloskey, E. V. (2020). Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures. Osteoporosis International. 31(10), pp. 1817-1828. https://doi.org/10.1007/s00198-020-05517-7 |
op_rights |
All rights reserved |
op_doi |
https://doi.org/10.1007/s00198-020-05517-7 |
container_title |
Osteoporosis International |
container_volume |
31 |
container_issue |
10 |
container_start_page |
1817 |
op_container_end_page |
1828 |
_version_ |
1776201261046038528 |