Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study
Background: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in uric acid on renal outcome has not been asse...
Published in: | BMC Nephrology |
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Biomed Central Ltd
2015
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Online Access: | https://acuresearchbank.acu.edu.au/download/0682a22641169a492c2001f1b3f9842b8b70ba7324e3c06293d209f7c3874987/687955/OA_Storhaug_2015_Uric_acid_is_associated_with_microalbuminuria.pdf https://doi.org/10.1186/S12882-015-0207-1 |
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ftaustraliancuni:oai:acuresearchbank.acu.edu.au:8v4xx 2023-09-05T13:23:47+02:00 Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study Storhaug, Hilde M. Toft, Ingrid Norvik, Jon V. Jenssen, Trond Eriksen, Bjørn O. Melsom, Toralf Løchen, Maja-Lisa Solbu, Marit Dahl 2015 application/pdf https://acuresearchbank.acu.edu.au/download/0682a22641169a492c2001f1b3f9842b8b70ba7324e3c06293d209f7c3874987/687955/OA_Storhaug_2015_Uric_acid_is_associated_with_microalbuminuria.pdf https://doi.org/10.1186/S12882-015-0207-1 unknown Biomed Central Ltd https://acuresearchbank.acu.edu.au/item/8v4xx/uric-acid-is-associated-with-microalbuminuria-and-decreased-glomerular-filtration-rate-in-the-general-population-during-7-and-13-years-of-followup-the-troms-study ISSN:1471-2369 https://acuresearchbank.acu.edu.au/download/0682a22641169a492c2001f1b3f9842b8b70ba7324e3c06293d209f7c3874987/687955/OA_Storhaug_2015_Uric_acid_is_associated_with_microalbuminuria.pdf https://doi.org/10.1186/S12882-015-0207-1 Storhaug, Hilde M., Toft, Ingrid, Norvik, Jon V., Jenssen, Trond, Eriksen, Bjørn O., Melsom, Toralf, Løchen, Maja-Lisa and Solbu, Marit Dahl. (2015). Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study. BMC Nephrology. 16(210), pp. 1 - 10. https://doi.org/10.1186/S12882-015-0207-1 serum uric acid renal dysfunction epidemiology albumin-creatinine ratio journal-article 2015 ftaustraliancuni https://doi.org/10.1186/S12882-015-0207-1 2023-08-11T14:27:14Z Background: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in uric acid on renal outcome has not been assessed previously. We aimed to study the impact of change in serum uric acid (SUA) as well as baseline SUA on the development of RD. Methods: In a prospective cohort study, we assessed the associations between change in SUA during follow-up, baseline SUA and RD (defined as albumin-creatinine-ratio (ACR) ≥1.13 mg albumin/mmol creatinine and/or eGFR < 60 ml/min/1.73 m2) in a large cohort from a general population participating in the Tromsø Study (n = 2637). Participants were stratified according to tertiles of change in SUA between baseline (1994/95) and follow-up 13 years later. (upper tertile: SUA increasing group, two lower tertiles: SUA non-increasing group). Logistic regression analysis was applied with RD and each component of RD after 7 and 13 years as the dependent variables. Adjustments were made for baseline eGFR, cardiovascular risk factors, and the use of antihypertensive drugs including diuretics. Results: After excluding participants with RD at baseline, SUA increasers, compared to SUA non-increasers, had a doubled risk of RD after 7 years (odds ratio 2.00, (95 % CI 1.45, 2.75)). Odds ratio for RD in SUA increasers after 13 years was 2.18 (95 % CI 1.71, 2.79). The risk of developing ACR ≥1.13 mg/mmol alone was not significantly increased after 7 years (odds ratio 1.30 (95 % CI 0.90, 1.89), but after 13 years (odds ratio 1.43 (95 % CI 1.09, 1.86)). An increase in baseline SUA of 59 μmol/L (1 mg/dL) gave an odds ratio for RD after 13 years of 1.16 (95 % CI 1.04, 1.29). Conclusion: An increase in SUA during follow-up was associated with an increased risk of developing RD after 7 and 13 years. Article in Journal/Newspaper Tromsø Australian Catholic University: ACU Research Bank Tromsø BMC Nephrology 16 1 |
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Open Polar |
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Australian Catholic University: ACU Research Bank |
op_collection_id |
ftaustraliancuni |
language |
unknown |
topic |
serum uric acid renal dysfunction epidemiology albumin-creatinine ratio |
spellingShingle |
serum uric acid renal dysfunction epidemiology albumin-creatinine ratio Storhaug, Hilde M. Toft, Ingrid Norvik, Jon V. Jenssen, Trond Eriksen, Bjørn O. Melsom, Toralf Løchen, Maja-Lisa Solbu, Marit Dahl Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study |
topic_facet |
serum uric acid renal dysfunction epidemiology albumin-creatinine ratio |
description |
Background: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in uric acid on renal outcome has not been assessed previously. We aimed to study the impact of change in serum uric acid (SUA) as well as baseline SUA on the development of RD. Methods: In a prospective cohort study, we assessed the associations between change in SUA during follow-up, baseline SUA and RD (defined as albumin-creatinine-ratio (ACR) ≥1.13 mg albumin/mmol creatinine and/or eGFR < 60 ml/min/1.73 m2) in a large cohort from a general population participating in the Tromsø Study (n = 2637). Participants were stratified according to tertiles of change in SUA between baseline (1994/95) and follow-up 13 years later. (upper tertile: SUA increasing group, two lower tertiles: SUA non-increasing group). Logistic regression analysis was applied with RD and each component of RD after 7 and 13 years as the dependent variables. Adjustments were made for baseline eGFR, cardiovascular risk factors, and the use of antihypertensive drugs including diuretics. Results: After excluding participants with RD at baseline, SUA increasers, compared to SUA non-increasers, had a doubled risk of RD after 7 years (odds ratio 2.00, (95 % CI 1.45, 2.75)). Odds ratio for RD in SUA increasers after 13 years was 2.18 (95 % CI 1.71, 2.79). The risk of developing ACR ≥1.13 mg/mmol alone was not significantly increased after 7 years (odds ratio 1.30 (95 % CI 0.90, 1.89), but after 13 years (odds ratio 1.43 (95 % CI 1.09, 1.86)). An increase in baseline SUA of 59 μmol/L (1 mg/dL) gave an odds ratio for RD after 13 years of 1.16 (95 % CI 1.04, 1.29). Conclusion: An increase in SUA during follow-up was associated with an increased risk of developing RD after 7 and 13 years. |
format |
Article in Journal/Newspaper |
author |
Storhaug, Hilde M. Toft, Ingrid Norvik, Jon V. Jenssen, Trond Eriksen, Bjørn O. Melsom, Toralf Løchen, Maja-Lisa Solbu, Marit Dahl |
author_facet |
Storhaug, Hilde M. Toft, Ingrid Norvik, Jon V. Jenssen, Trond Eriksen, Bjørn O. Melsom, Toralf Løchen, Maja-Lisa Solbu, Marit Dahl |
author_sort |
Storhaug, Hilde M. |
title |
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study |
title_short |
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study |
title_full |
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study |
title_fullStr |
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study |
title_full_unstemmed |
Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study |
title_sort |
uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: the tromsø study |
publisher |
Biomed Central Ltd |
publishDate |
2015 |
url |
https://acuresearchbank.acu.edu.au/download/0682a22641169a492c2001f1b3f9842b8b70ba7324e3c06293d209f7c3874987/687955/OA_Storhaug_2015_Uric_acid_is_associated_with_microalbuminuria.pdf https://doi.org/10.1186/S12882-015-0207-1 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://acuresearchbank.acu.edu.au/item/8v4xx/uric-acid-is-associated-with-microalbuminuria-and-decreased-glomerular-filtration-rate-in-the-general-population-during-7-and-13-years-of-followup-the-troms-study ISSN:1471-2369 https://acuresearchbank.acu.edu.au/download/0682a22641169a492c2001f1b3f9842b8b70ba7324e3c06293d209f7c3874987/687955/OA_Storhaug_2015_Uric_acid_is_associated_with_microalbuminuria.pdf https://doi.org/10.1186/S12882-015-0207-1 Storhaug, Hilde M., Toft, Ingrid, Norvik, Jon V., Jenssen, Trond, Eriksen, Bjørn O., Melsom, Toralf, Løchen, Maja-Lisa and Solbu, Marit Dahl. (2015). Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study. BMC Nephrology. 16(210), pp. 1 - 10. https://doi.org/10.1186/S12882-015-0207-1 |
op_doi |
https://doi.org/10.1186/S12882-015-0207-1 |
container_title |
BMC Nephrology |
container_volume |
16 |
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1 |
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1776204359828242432 |