The DBP phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study
Background and Objective In addition to its role as a transport protein, the vitamin D binding protein (DBP) may also affect lipid metabolism, inflammation and carcinogenesis. There are three common variants of the DBP, Gc1s (1s), Gc1f (1f), Gc2 (2) that result in six common phenotypes (1s/1s, 1s/1f...
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2015
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Online Access: | https://acuresearchbank.acu.edu.au/download/6239bc057dd3f1fe39f7f129aecbc4208c006cd10d5d718504049712319cbd14/182484/Jorde_2015_The_DBP_phenotype_Gc_1f_Gc_1f_is.pdf https://doi.org/10.1371/journal.pone.0126359 |
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ftaustraliancuni:oai:acuresearchbank.acu.edu.au:8q53x 2023-09-05T13:23:47+02:00 The DBP phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study Jorde, Rolf Schirmer, Henrik Wilsgaard, Tom Mathiesen, Ellisiv Bøgeberg Njølstad, Inger Loechen, Maja-Lisa Joakimsen, Ragnar Martin Grimnes, Guri 2015 application/pdf https://acuresearchbank.acu.edu.au/download/6239bc057dd3f1fe39f7f129aecbc4208c006cd10d5d718504049712319cbd14/182484/Jorde_2015_The_DBP_phenotype_Gc_1f_Gc_1f_is.pdf https://doi.org/10.1371/journal.pone.0126359 unknown Public Library of Science https://acuresearchbank.acu.edu.au/item/8q53x/the-dbp-phenotype-gc-1f-gc-1f-is-associated-with-reduced-risk-of-cancer-the-troms-study ISSN:1932-6203 https://acuresearchbank.acu.edu.au/download/6239bc057dd3f1fe39f7f129aecbc4208c006cd10d5d718504049712319cbd14/182484/Jorde_2015_The_DBP_phenotype_Gc_1f_Gc_1f_is.pdf https://doi.org/10.1371/journal.pone.0126359 Jorde, Rolf, Schirmer, Henrik, Wilsgaard, Tom, Mathiesen, Ellisiv Bøgeberg, Njølstad, Inger, Loechen, Maja-Lisa, Joakimsen, Ragnar Martin and Grimnes, Guri. (2015). The DBP phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study. PLoS ONE. 10(5), pp. 1 - 11. https://doi.org/10.1371/journal.pone.0126359 journal-article 2015 ftaustraliancuni https://doi.org/10.1371/journal.pone.0126359 2023-08-11T14:41:31Z Background and Objective In addition to its role as a transport protein, the vitamin D binding protein (DBP) may also affect lipid metabolism, inflammation and carcinogenesis. There are three common variants of the DBP, Gc1s (1s), Gc1f (1f), Gc2 (2) that result in six common phenotypes (1s/1s, 1s/1f, 1s/2, 1f/1f, 1f/2, and 2/2). These phenotypes can be identified by genotyping for the two single nucleotide polymorphisms rs7041 and rs4588 in the GC gene. The DBP variants have different binding coefficients for the vitamin D metabolites, and accordingly there may be important relations between DBP phenotypes and health. Methods DNA was prepared from subjects who participated in the fourth survey of the Tromsø Study in 1994-1995 and who were registered with the endpoints myocardial infarction (MI), type 2 diabetes (T2DM), cancer or death as well as a randomly selected control group. The endpoint registers were complete up to 2010- 2013. Genotyping was performed for rs7041 and rs4588 and serum 25-hydroxyvitamin D (25(OH)D) was measured. Results Genotyping for rs7041 and rs4588 was performed successfully in 11 704 subjects. Among these, 1660 were registered with incident MI, 958 with T2DM, 2410 with cancer and 4318 had died. Subjects with the DBP phenotype 1f/1f had 23 – 26 % reduced risk of incident cancer compared to the 1s/1s and 2/2 phenotypes (P < 0.02, Cox regression with gender as covariate). Differences in serum 25(OH)D levels could not explain the apparent cancer protective effect of the DBP variant 1f. In addition to cancer and 25(OH)D, there were significant associations between DBP phenotype and body height, hip circumference and serum calcium. Conclusion There are important biological differences between the common DBP phenotypes. If the relation between the DBP variant 1f and cancer is confirmed in other studies, determination of DBP phenotype may have clinical importance. Article in Journal/Newspaper Tromsø Australian Catholic University: ACU Research Bank Tromsø PLOS ONE 10 5 e0126359 |
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Open Polar |
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Australian Catholic University: ACU Research Bank |
op_collection_id |
ftaustraliancuni |
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unknown |
description |
Background and Objective In addition to its role as a transport protein, the vitamin D binding protein (DBP) may also affect lipid metabolism, inflammation and carcinogenesis. There are three common variants of the DBP, Gc1s (1s), Gc1f (1f), Gc2 (2) that result in six common phenotypes (1s/1s, 1s/1f, 1s/2, 1f/1f, 1f/2, and 2/2). These phenotypes can be identified by genotyping for the two single nucleotide polymorphisms rs7041 and rs4588 in the GC gene. The DBP variants have different binding coefficients for the vitamin D metabolites, and accordingly there may be important relations between DBP phenotypes and health. Methods DNA was prepared from subjects who participated in the fourth survey of the Tromsø Study in 1994-1995 and who were registered with the endpoints myocardial infarction (MI), type 2 diabetes (T2DM), cancer or death as well as a randomly selected control group. The endpoint registers were complete up to 2010- 2013. Genotyping was performed for rs7041 and rs4588 and serum 25-hydroxyvitamin D (25(OH)D) was measured. Results Genotyping for rs7041 and rs4588 was performed successfully in 11 704 subjects. Among these, 1660 were registered with incident MI, 958 with T2DM, 2410 with cancer and 4318 had died. Subjects with the DBP phenotype 1f/1f had 23 – 26 % reduced risk of incident cancer compared to the 1s/1s and 2/2 phenotypes (P < 0.02, Cox regression with gender as covariate). Differences in serum 25(OH)D levels could not explain the apparent cancer protective effect of the DBP variant 1f. In addition to cancer and 25(OH)D, there were significant associations between DBP phenotype and body height, hip circumference and serum calcium. Conclusion There are important biological differences between the common DBP phenotypes. If the relation between the DBP variant 1f and cancer is confirmed in other studies, determination of DBP phenotype may have clinical importance. |
format |
Article in Journal/Newspaper |
author |
Jorde, Rolf Schirmer, Henrik Wilsgaard, Tom Mathiesen, Ellisiv Bøgeberg Njølstad, Inger Loechen, Maja-Lisa Joakimsen, Ragnar Martin Grimnes, Guri |
spellingShingle |
Jorde, Rolf Schirmer, Henrik Wilsgaard, Tom Mathiesen, Ellisiv Bøgeberg Njølstad, Inger Loechen, Maja-Lisa Joakimsen, Ragnar Martin Grimnes, Guri The DBP phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study |
author_facet |
Jorde, Rolf Schirmer, Henrik Wilsgaard, Tom Mathiesen, Ellisiv Bøgeberg Njølstad, Inger Loechen, Maja-Lisa Joakimsen, Ragnar Martin Grimnes, Guri |
author_sort |
Jorde, Rolf |
title |
The DBP phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study |
title_short |
The DBP phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study |
title_full |
The DBP phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study |
title_fullStr |
The DBP phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study |
title_full_unstemmed |
The DBP phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study |
title_sort |
dbp phenotype gc-1f/gc-1f is associated with reduced risk of cancer. the tromsø study |
publisher |
Public Library of Science |
publishDate |
2015 |
url |
https://acuresearchbank.acu.edu.au/download/6239bc057dd3f1fe39f7f129aecbc4208c006cd10d5d718504049712319cbd14/182484/Jorde_2015_The_DBP_phenotype_Gc_1f_Gc_1f_is.pdf https://doi.org/10.1371/journal.pone.0126359 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://acuresearchbank.acu.edu.au/item/8q53x/the-dbp-phenotype-gc-1f-gc-1f-is-associated-with-reduced-risk-of-cancer-the-troms-study ISSN:1932-6203 https://acuresearchbank.acu.edu.au/download/6239bc057dd3f1fe39f7f129aecbc4208c006cd10d5d718504049712319cbd14/182484/Jorde_2015_The_DBP_phenotype_Gc_1f_Gc_1f_is.pdf https://doi.org/10.1371/journal.pone.0126359 Jorde, Rolf, Schirmer, Henrik, Wilsgaard, Tom, Mathiesen, Ellisiv Bøgeberg, Njølstad, Inger, Loechen, Maja-Lisa, Joakimsen, Ragnar Martin and Grimnes, Guri. (2015). The DBP phenotype Gc-1f/Gc-1f is associated with reduced risk of cancer. The Tromsø Study. PLoS ONE. 10(5), pp. 1 - 11. https://doi.org/10.1371/journal.pone.0126359 |
op_doi |
https://doi.org/10.1371/journal.pone.0126359 |
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