Impact of chronic inflammation, assessed by hs-CRP, on the association between red cell distribution width and arterial cardiovascular disease: the Tromso Study
Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic inflammation as measured by high-sensitivity C-reacti...
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Georg Thieme Verlag
2018
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ftaustraliancuni:oai:acuresearchbank.acu.edu.au:89wq9 2023-09-05T13:23:45+02:00 Impact of chronic inflammation, assessed by hs-CRP, on the association between red cell distribution width and arterial cardiovascular disease: the Tromso Study Lappegard, Jostein Ellingsen, Trygve S. Hindberg, Kristian Mathiesen, Ellisiv Bøgeberg Njolstad, Inger Wilsgaard, Tom Loechen, Maja-Lisa Braekkan, Sigrid Kufaas Hansen, John-Bjarne 2018 application/pdf https://acuresearchbank.acu.edu.au/download/7d0e08a6bf74771a1dd5d74528eb9c7c25c54d8eeebb722a3acfbeed4b9793e0/190465/OA_Lappegard_2018_Impact_of_Chronic_Inflammation_assessed_by.pdf https://doi.org/10.1055/s-0038-1651523 unknown Georg Thieme Verlag https://acuresearchbank.acu.edu.au/item/89wq9/impact-of-chronic-inflammation-assessed-by-hs-crp-on-the-association-between-red-cell-distribution-width-and-arterial-cardiovascular-disease-the-tromso-study ISSN:2512-9465 https://acuresearchbank.acu.edu.au/download/7d0e08a6bf74771a1dd5d74528eb9c7c25c54d8eeebb722a3acfbeed4b9793e0/190465/OA_Lappegard_2018_Impact_of_Chronic_Inflammation_assessed_by.pdf https://doi.org/10.1055/s-0038-1651523 Lappegard, Jostein, Ellingsen, Trygve S., Hindberg, Kristian, Mathiesen, Ellisiv Bøgeberg, Njolstad, Inger, Wilsgaard, Tom, Loechen, Maja-Lisa, Braekkan, Sigrid Kufaas and Hansen, John-Bjarne. (2018). Impact of chronic inflammation, assessed by hs-CRP, on the association between red cell distribution width and arterial cardiovascular disease: the Tromso Study. TH Open. 2(2), pp. 182 - 189. https://doi.org/10.1055/s-0038-1651523 CC BY 4.0 epidemiology myocardial infarction stroke blood cells risk factors journal-article 2018 ftaustraliancuni https://doi.org/10.1055/s-0038-1651523 2023-08-11T14:49:45Z Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) on this relationship, and explore whether RDW could be a mediator in the causal pathway between inflammation and arterial CVD. Baseline characteristics, including RDW and hs-CRP, were obtained from 5,765 individuals attending a population-based cohort study. We followed up participants from inclusion in the fourth survey of the Tromsø Study (1994/1995) until December 31, 2012. Multivariable Cox-regression models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI) for incident myocardial infarction (MI) and ischemic stroke across quintiles of hs-CRP and RDW. Subjects with hs-CRP in the highest quintile had 44% higher risk of MI (HR: 1.44, 95% CI: 1.14–1.80), and 64% higher risk of ischemic stroke (HR: 1.64, 95% CI: 1.20–2.24) compared with subjects in the lowest quintile. RDW mediated 7.2% (95% CI: 4.0–30.8%) of the association between hs-CRP and ischemic stroke. Subjects with RDW in the highest quintile had 22% higher risk of MI (HR: 1.22, 95% CI: 0.98–1.54) and 44% higher risk of ischemic stroke (HR: 1.44, 95% CI: 1.06–1.97) compared with subjects in the lowest quintile. These risk estimates were slightly attenuated after adjustments for hs-CRP. Our findings suggest that chronic inflammation is not a primary mechanism underlying the relationship between RDW and arterial CVD. Article in Journal/Newspaper Tromso Tromso Tromsø Australian Catholic University: ACU Research Bank Tromso ENVELOPE(16.546,16.546,68.801,68.801) Tromsø TH Open 02 02 e182 e189 |
institution |
Open Polar |
collection |
Australian Catholic University: ACU Research Bank |
op_collection_id |
ftaustraliancuni |
language |
unknown |
topic |
epidemiology myocardial infarction stroke blood cells risk factors |
spellingShingle |
epidemiology myocardial infarction stroke blood cells risk factors Lappegard, Jostein Ellingsen, Trygve S. Hindberg, Kristian Mathiesen, Ellisiv Bøgeberg Njolstad, Inger Wilsgaard, Tom Loechen, Maja-Lisa Braekkan, Sigrid Kufaas Hansen, John-Bjarne Impact of chronic inflammation, assessed by hs-CRP, on the association between red cell distribution width and arterial cardiovascular disease: the Tromso Study |
topic_facet |
epidemiology myocardial infarction stroke blood cells risk factors |
description |
Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) on this relationship, and explore whether RDW could be a mediator in the causal pathway between inflammation and arterial CVD. Baseline characteristics, including RDW and hs-CRP, were obtained from 5,765 individuals attending a population-based cohort study. We followed up participants from inclusion in the fourth survey of the Tromsø Study (1994/1995) until December 31, 2012. Multivariable Cox-regression models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI) for incident myocardial infarction (MI) and ischemic stroke across quintiles of hs-CRP and RDW. Subjects with hs-CRP in the highest quintile had 44% higher risk of MI (HR: 1.44, 95% CI: 1.14–1.80), and 64% higher risk of ischemic stroke (HR: 1.64, 95% CI: 1.20–2.24) compared with subjects in the lowest quintile. RDW mediated 7.2% (95% CI: 4.0–30.8%) of the association between hs-CRP and ischemic stroke. Subjects with RDW in the highest quintile had 22% higher risk of MI (HR: 1.22, 95% CI: 0.98–1.54) and 44% higher risk of ischemic stroke (HR: 1.44, 95% CI: 1.06–1.97) compared with subjects in the lowest quintile. These risk estimates were slightly attenuated after adjustments for hs-CRP. Our findings suggest that chronic inflammation is not a primary mechanism underlying the relationship between RDW and arterial CVD. |
format |
Article in Journal/Newspaper |
author |
Lappegard, Jostein Ellingsen, Trygve S. Hindberg, Kristian Mathiesen, Ellisiv Bøgeberg Njolstad, Inger Wilsgaard, Tom Loechen, Maja-Lisa Braekkan, Sigrid Kufaas Hansen, John-Bjarne |
author_facet |
Lappegard, Jostein Ellingsen, Trygve S. Hindberg, Kristian Mathiesen, Ellisiv Bøgeberg Njolstad, Inger Wilsgaard, Tom Loechen, Maja-Lisa Braekkan, Sigrid Kufaas Hansen, John-Bjarne |
author_sort |
Lappegard, Jostein |
title |
Impact of chronic inflammation, assessed by hs-CRP, on the association between red cell distribution width and arterial cardiovascular disease: the Tromso Study |
title_short |
Impact of chronic inflammation, assessed by hs-CRP, on the association between red cell distribution width and arterial cardiovascular disease: the Tromso Study |
title_full |
Impact of chronic inflammation, assessed by hs-CRP, on the association between red cell distribution width and arterial cardiovascular disease: the Tromso Study |
title_fullStr |
Impact of chronic inflammation, assessed by hs-CRP, on the association between red cell distribution width and arterial cardiovascular disease: the Tromso Study |
title_full_unstemmed |
Impact of chronic inflammation, assessed by hs-CRP, on the association between red cell distribution width and arterial cardiovascular disease: the Tromso Study |
title_sort |
impact of chronic inflammation, assessed by hs-crp, on the association between red cell distribution width and arterial cardiovascular disease: the tromso study |
publisher |
Georg Thieme Verlag |
publishDate |
2018 |
url |
https://acuresearchbank.acu.edu.au/download/7d0e08a6bf74771a1dd5d74528eb9c7c25c54d8eeebb722a3acfbeed4b9793e0/190465/OA_Lappegard_2018_Impact_of_Chronic_Inflammation_assessed_by.pdf https://doi.org/10.1055/s-0038-1651523 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso Tromsø |
geographic_facet |
Tromso Tromsø |
genre |
Tromso Tromso Tromsø |
genre_facet |
Tromso Tromso Tromsø |
op_relation |
https://acuresearchbank.acu.edu.au/item/89wq9/impact-of-chronic-inflammation-assessed-by-hs-crp-on-the-association-between-red-cell-distribution-width-and-arterial-cardiovascular-disease-the-tromso-study ISSN:2512-9465 https://acuresearchbank.acu.edu.au/download/7d0e08a6bf74771a1dd5d74528eb9c7c25c54d8eeebb722a3acfbeed4b9793e0/190465/OA_Lappegard_2018_Impact_of_Chronic_Inflammation_assessed_by.pdf https://doi.org/10.1055/s-0038-1651523 Lappegard, Jostein, Ellingsen, Trygve S., Hindberg, Kristian, Mathiesen, Ellisiv Bøgeberg, Njolstad, Inger, Wilsgaard, Tom, Loechen, Maja-Lisa, Braekkan, Sigrid Kufaas and Hansen, John-Bjarne. (2018). Impact of chronic inflammation, assessed by hs-CRP, on the association between red cell distribution width and arterial cardiovascular disease: the Tromso Study. TH Open. 2(2), pp. 182 - 189. https://doi.org/10.1055/s-0038-1651523 |
op_rights |
CC BY 4.0 |
op_doi |
https://doi.org/10.1055/s-0038-1651523 |
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TH Open |
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02 |
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02 |
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e182 |
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1776204337420173312 |