Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study
Aims: Whether atrial fibrillation is related to risk of venous thromboembolism (VTE) has not been extensively studied. Therefore, we investigated the association between atrial fibrillation and future risk of VTE in a population-based cohort. Methods: In total, 29 975 subjects were recruited from th...
Published in: | Journal of Thrombosis and Haemostasis |
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2015
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Online Access: | https://doi.org/10.1111/jth.12762 |
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ftaustraliancuni:oai:acuresearchbank.acu.edu.au:89q21 2023-09-05T13:23:46+02:00 Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study Enga, Kristin F. Rye-Holmboe, I. Hald, Erin M. Løchen, Maja-Lisa Mathiesen, E. B. Njølstad, I. Wilsgaard, Tom Braekkan, S. K. Hansen, John-Bjarne 2015 https://doi.org/10.1111/jth.12762 unknown Wiley-Blackwell Publishing Ltd. https://acuresearchbank.acu.edu.au/item/89q21/atrial-fibrillation-and-future-risk-of-venous-thromboembolism-the-troms-study ISSN:1538-7836 https://doi.org/10.1111/jth.12762 Enga, Kristin F., Rye-Holmboe, I., Hald, Erin M., Løchen, Maja-Lisa, Mathiesen, E. B., Njølstad, I., Wilsgaard, Tom, Braekkan, S. K. and Hansen, John-Bjarne. (2015). Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study. Journal of Thrombosis and Haemostasis. 13(1), pp. 10 - 16. https://doi.org/10.1111/jth.12762 atrial fibrillation cohort studies deep vein thrombosis pulmonary embolism risk factors journal-article 2015 ftaustraliancuni https://doi.org/10.1111/jth.12762 2023-08-11T14:52:17Z Aims: Whether atrial fibrillation is related to risk of venous thromboembolism (VTE) has not been extensively studied. Therefore, we investigated the association between atrial fibrillation and future risk of VTE in a population-based cohort. Methods: In total, 29 975 subjects were recruited from three surveys of the Tromsø study and followed from enrollment (1994–1995, 2001–2002 and 2007–2008) up to 2010. Incident events of atrial fibrillation and VTE during follow-up were recorded. Information on potential confounders was obtained at baseline. Cox-regression models with atrial fibrillation as time-dependent variable were used to calculate hazard ratios (HRs) for VTE with 95% confidence intervals (CIs). Results: During 16 years of median follow-up, 1604 subjects were diagnosed with atrial fibrillation and 614 with incident VTE. The risk of VTE was substantially increased during the first 6 months after diagnosis of atrial fibrillation (HR, 8.44; 95% CI, 5.61–12.69), and remained increased throughout the study period (HR, 1.43; 95% CI, 1.43–1.99) compared with those without atrial fibrillation. Atrial fibrillation displayed higher risk estimates for pulmonary embolism (HR, 11.84; 95% CI, 6.80–20.63) than for deep vein thrombosis (HR, 6.20; 95% CI, 3.37–11.39) during the first 6 months, and was still associated with pulmonary embolism (HR, 1.96; 95% CI, 1.24–3.10) but not with deep vein thrombosis (HR, 1.08; 95% CI, 0.66–1.75) more than 6 months after diagnosis. Conclusion: Atrial fibrillation was associated with increased risk of VTE, and pulmonary embolism in particular. Our findings support the concept that isolated pulmonary embolism may originate from right atrial thrombi due to atrial fibrillation. Article in Journal/Newspaper Tromsø Australian Catholic University: ACU Research Bank Tromsø Journal of Thrombosis and Haemostasis 13 1 10 16 |
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Australian Catholic University: ACU Research Bank |
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ftaustraliancuni |
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unknown |
topic |
atrial fibrillation cohort studies deep vein thrombosis pulmonary embolism risk factors |
spellingShingle |
atrial fibrillation cohort studies deep vein thrombosis pulmonary embolism risk factors Enga, Kristin F. Rye-Holmboe, I. Hald, Erin M. Løchen, Maja-Lisa Mathiesen, E. B. Njølstad, I. Wilsgaard, Tom Braekkan, S. K. Hansen, John-Bjarne Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study |
topic_facet |
atrial fibrillation cohort studies deep vein thrombosis pulmonary embolism risk factors |
description |
Aims: Whether atrial fibrillation is related to risk of venous thromboembolism (VTE) has not been extensively studied. Therefore, we investigated the association between atrial fibrillation and future risk of VTE in a population-based cohort. Methods: In total, 29 975 subjects were recruited from three surveys of the Tromsø study and followed from enrollment (1994–1995, 2001–2002 and 2007–2008) up to 2010. Incident events of atrial fibrillation and VTE during follow-up were recorded. Information on potential confounders was obtained at baseline. Cox-regression models with atrial fibrillation as time-dependent variable were used to calculate hazard ratios (HRs) for VTE with 95% confidence intervals (CIs). Results: During 16 years of median follow-up, 1604 subjects were diagnosed with atrial fibrillation and 614 with incident VTE. The risk of VTE was substantially increased during the first 6 months after diagnosis of atrial fibrillation (HR, 8.44; 95% CI, 5.61–12.69), and remained increased throughout the study period (HR, 1.43; 95% CI, 1.43–1.99) compared with those without atrial fibrillation. Atrial fibrillation displayed higher risk estimates for pulmonary embolism (HR, 11.84; 95% CI, 6.80–20.63) than for deep vein thrombosis (HR, 6.20; 95% CI, 3.37–11.39) during the first 6 months, and was still associated with pulmonary embolism (HR, 1.96; 95% CI, 1.24–3.10) but not with deep vein thrombosis (HR, 1.08; 95% CI, 0.66–1.75) more than 6 months after diagnosis. Conclusion: Atrial fibrillation was associated with increased risk of VTE, and pulmonary embolism in particular. Our findings support the concept that isolated pulmonary embolism may originate from right atrial thrombi due to atrial fibrillation. |
format |
Article in Journal/Newspaper |
author |
Enga, Kristin F. Rye-Holmboe, I. Hald, Erin M. Løchen, Maja-Lisa Mathiesen, E. B. Njølstad, I. Wilsgaard, Tom Braekkan, S. K. Hansen, John-Bjarne |
author_facet |
Enga, Kristin F. Rye-Holmboe, I. Hald, Erin M. Løchen, Maja-Lisa Mathiesen, E. B. Njølstad, I. Wilsgaard, Tom Braekkan, S. K. Hansen, John-Bjarne |
author_sort |
Enga, Kristin F. |
title |
Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study |
title_short |
Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study |
title_full |
Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study |
title_fullStr |
Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study |
title_full_unstemmed |
Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study |
title_sort |
atrial fibrillation and future risk of venous thromboembolism: the tromsø study |
publisher |
Wiley-Blackwell Publishing Ltd. |
publishDate |
2015 |
url |
https://doi.org/10.1111/jth.12762 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://acuresearchbank.acu.edu.au/item/89q21/atrial-fibrillation-and-future-risk-of-venous-thromboembolism-the-troms-study ISSN:1538-7836 https://doi.org/10.1111/jth.12762 Enga, Kristin F., Rye-Holmboe, I., Hald, Erin M., Løchen, Maja-Lisa, Mathiesen, E. B., Njølstad, I., Wilsgaard, Tom, Braekkan, S. K. and Hansen, John-Bjarne. (2015). Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study. Journal of Thrombosis and Haemostasis. 13(1), pp. 10 - 16. https://doi.org/10.1111/jth.12762 |
op_doi |
https://doi.org/10.1111/jth.12762 |
container_title |
Journal of Thrombosis and Haemostasis |
container_volume |
13 |
container_issue |
1 |
container_start_page |
10 |
op_container_end_page |
16 |
_version_ |
1776204354981724160 |