Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study
Background: Pulmonary embolism (PE) may trigger atrial fibrillation through increased right atrial pressure and subsequent atrial strain, but the degree of evidence is low. In this study, we wanted to investigate the impact of incident venous thromboembolism (VTE) on future risk of atrial fibrillati...
Published in: | Journal of the American Heart Association |
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Wiley-Blackwell Publishing, Inc.
2014
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Online Access: | https://acuresearchbank.acu.edu.au/download/116c689790c4a33557f20d8063fcb75123e3a178a213983390e676ce4136ccb6/261668/OA_Hald_2014_Venous_thromboembolism_increases_the_risk_of.pdf https://doi.org/10.1161/JAHA.113.000483 |
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ftaustraliancuni:oai:acuresearchbank.acu.edu.au:895xv 2023-09-05T13:23:46+02:00 Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study Hald, Erin M. Enga, Kristin F. Løchen, Maja-Lisa Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Braekkan, Sigrid K. Hansen, John-Bjarne 2014 application/pdf https://acuresearchbank.acu.edu.au/download/116c689790c4a33557f20d8063fcb75123e3a178a213983390e676ce4136ccb6/261668/OA_Hald_2014_Venous_thromboembolism_increases_the_risk_of.pdf https://doi.org/10.1161/JAHA.113.000483 unknown Wiley-Blackwell Publishing, Inc. https://acuresearchbank.acu.edu.au/item/895xv/venous-thromboembolism-increases-the-risk-of-atrial-fibrillation-the-troms-study ISSN:2047-9980 https://acuresearchbank.acu.edu.au/download/116c689790c4a33557f20d8063fcb75123e3a178a213983390e676ce4136ccb6/261668/OA_Hald_2014_Venous_thromboembolism_increases_the_risk_of.pdf https://doi.org/10.1161/JAHA.113.000483 Hald, Erin M., Enga, Kristin F., Løchen, Maja-Lisa, Mathiesen, Ellisiv B., Njølstad, Inger, Wilsgaard, Tom, Braekkan, Sigrid K. and Hansen, John-Bjarne. (2014). Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study. Journal of the American Heart Association. 3(1), pp. 1 - 7. https://doi.org/10.1161/JAHA.113.000483 epidemiology fibrillation pulmonary heart disease thrombosis journal-article 2014 ftaustraliancuni https://doi.org/10.1161/JAHA.113.000483 2023-08-11T14:56:31Z Background: Pulmonary embolism (PE) may trigger atrial fibrillation through increased right atrial pressure and subsequent atrial strain, but the degree of evidence is low. In this study, we wanted to investigate the impact of incident venous thromboembolism (VTE) on future risk of atrial fibrillation in a prospective population-based study. Methods and Results: The study included 29 974 subjects recruited from the Tromsø study (1994–1995, 2001–2002, 2007–2008). Incident VTE and atrial fibrillation events were registered from date of enrolment to end of follow-up, December 31, 2010. Cox proportional hazard regression models using age as time-scale and VTE as a time-dependent variable were used to estimate crude and multivariable hazard ratios (HRs) for atrial fibrillation with 95% confidence intervals (CIs). During 16 years of follow up, 540 (1.8%) subjects had an incident VTE event, and 1662 (5.54%) were diagnosed with atrial fibrillation. Among those with VTE, 50 (9.3%) developed subsequent atrial fibrillation. Patients with VTE had 63% higher risk of atrial fibrillation compared to subjects without VTE (multivariable-adjusted HR: 1.63, 95% CI: 1.22 to 2.17). The risk of atrial fibrillation was particularly high during the first 6 months after the VTE event (HR 4.00, 95% CI: 2.21 to 7.25) and among those with PE (HR 1.78, 95% CI: 1.13 to 2.80). Conclusions: We found that incident VTE was associated with future risk of atrial fibrillation. Our findings support the hypothesis that PE may lead to cardiac dysfunctions that, in turn, could trigger atrial fibrillation. Article in Journal/Newspaper Tromsø Australian Catholic University: ACU Research Bank Tromsø Journal of the American Heart Association 3 1 |
institution |
Open Polar |
collection |
Australian Catholic University: ACU Research Bank |
op_collection_id |
ftaustraliancuni |
language |
unknown |
topic |
epidemiology fibrillation pulmonary heart disease thrombosis |
spellingShingle |
epidemiology fibrillation pulmonary heart disease thrombosis Hald, Erin M. Enga, Kristin F. Løchen, Maja-Lisa Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Braekkan, Sigrid K. Hansen, John-Bjarne Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study |
topic_facet |
epidemiology fibrillation pulmonary heart disease thrombosis |
description |
Background: Pulmonary embolism (PE) may trigger atrial fibrillation through increased right atrial pressure and subsequent atrial strain, but the degree of evidence is low. In this study, we wanted to investigate the impact of incident venous thromboembolism (VTE) on future risk of atrial fibrillation in a prospective population-based study. Methods and Results: The study included 29 974 subjects recruited from the Tromsø study (1994–1995, 2001–2002, 2007–2008). Incident VTE and atrial fibrillation events were registered from date of enrolment to end of follow-up, December 31, 2010. Cox proportional hazard regression models using age as time-scale and VTE as a time-dependent variable were used to estimate crude and multivariable hazard ratios (HRs) for atrial fibrillation with 95% confidence intervals (CIs). During 16 years of follow up, 540 (1.8%) subjects had an incident VTE event, and 1662 (5.54%) were diagnosed with atrial fibrillation. Among those with VTE, 50 (9.3%) developed subsequent atrial fibrillation. Patients with VTE had 63% higher risk of atrial fibrillation compared to subjects without VTE (multivariable-adjusted HR: 1.63, 95% CI: 1.22 to 2.17). The risk of atrial fibrillation was particularly high during the first 6 months after the VTE event (HR 4.00, 95% CI: 2.21 to 7.25) and among those with PE (HR 1.78, 95% CI: 1.13 to 2.80). Conclusions: We found that incident VTE was associated with future risk of atrial fibrillation. Our findings support the hypothesis that PE may lead to cardiac dysfunctions that, in turn, could trigger atrial fibrillation. |
format |
Article in Journal/Newspaper |
author |
Hald, Erin M. Enga, Kristin F. Løchen, Maja-Lisa Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Braekkan, Sigrid K. Hansen, John-Bjarne |
author_facet |
Hald, Erin M. Enga, Kristin F. Løchen, Maja-Lisa Mathiesen, Ellisiv B. Njølstad, Inger Wilsgaard, Tom Braekkan, Sigrid K. Hansen, John-Bjarne |
author_sort |
Hald, Erin M. |
title |
Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study |
title_short |
Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study |
title_full |
Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study |
title_fullStr |
Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study |
title_full_unstemmed |
Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study |
title_sort |
venous thromboembolism increases the risk of atrial fibrillation: the tromsø study |
publisher |
Wiley-Blackwell Publishing, Inc. |
publishDate |
2014 |
url |
https://acuresearchbank.acu.edu.au/download/116c689790c4a33557f20d8063fcb75123e3a178a213983390e676ce4136ccb6/261668/OA_Hald_2014_Venous_thromboembolism_increases_the_risk_of.pdf https://doi.org/10.1161/JAHA.113.000483 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://acuresearchbank.acu.edu.au/item/895xv/venous-thromboembolism-increases-the-risk-of-atrial-fibrillation-the-troms-study ISSN:2047-9980 https://acuresearchbank.acu.edu.au/download/116c689790c4a33557f20d8063fcb75123e3a178a213983390e676ce4136ccb6/261668/OA_Hald_2014_Venous_thromboembolism_increases_the_risk_of.pdf https://doi.org/10.1161/JAHA.113.000483 Hald, Erin M., Enga, Kristin F., Løchen, Maja-Lisa, Mathiesen, Ellisiv B., Njølstad, Inger, Wilsgaard, Tom, Braekkan, Sigrid K. and Hansen, John-Bjarne. (2014). Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study. Journal of the American Heart Association. 3(1), pp. 1 - 7. https://doi.org/10.1161/JAHA.113.000483 |
op_doi |
https://doi.org/10.1161/JAHA.113.000483 |
container_title |
Journal of the American Heart Association |
container_volume |
3 |
container_issue |
1 |
_version_ |
1776204353332314112 |