Genetic variations in the vitamin d receptor predict type 2 diabetes and myocardial infarction in a community-based population: The Tromsø Study
Background Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and mortality are well-studied, the effect of supplementation with vitamin D is uncertain. This may be related to genetic d...
Published in: | PLOS ONE |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
Public Library of Science
2015
|
Subjects: | |
Online Access: | https://acuresearchbank.acu.edu.au/download/6d55b56f97d261f379bc4ed19a0811ebb408be2905fd0b2d516414259de7d68e/247263/Zostautiene_2015_Genetic_variations_in_the_vitamin_d.pdf https://doi.org/10.1371/journal.pone.0145359 |
id |
ftaustraliancuni:oai:acuresearchbank.acu.edu.au:8861v |
---|---|
record_format |
openpolar |
spelling |
ftaustraliancuni:oai:acuresearchbank.acu.edu.au:8861v 2023-09-05T13:23:47+02:00 Genetic variations in the vitamin d receptor predict type 2 diabetes and myocardial infarction in a community-based population: The Tromsø Study Zostautiene, Ieva Jorde, Rolf Schirmer, Henrik Mathiesen, Ellisiv Bøgeberg Njølstad, Inger Loechen, Maja-Lisa Wilsgaard, Tom Joakimsen, Ragnar Martin Kamycheva, Elena 2015 application/pdf https://acuresearchbank.acu.edu.au/download/6d55b56f97d261f379bc4ed19a0811ebb408be2905fd0b2d516414259de7d68e/247263/Zostautiene_2015_Genetic_variations_in_the_vitamin_d.pdf https://doi.org/10.1371/journal.pone.0145359 unknown Public Library of Science https://acuresearchbank.acu.edu.au/item/8861v/genetic-variations-in-the-vitamin-d-receptor-predict-type-2-diabetes-and-myocardial-infarction-in-a-community-based-population-the-troms-study ISSN:1932-6203 https://acuresearchbank.acu.edu.au/download/6d55b56f97d261f379bc4ed19a0811ebb408be2905fd0b2d516414259de7d68e/247263/Zostautiene_2015_Genetic_variations_in_the_vitamin_d.pdf https://doi.org/10.1371/journal.pone.0145359 Zostautiene, Ieva, Jorde, Rolf, Schirmer, Henrik, Mathiesen, Ellisiv Bøgeberg, Njølstad, Inger, Loechen, Maja-Lisa, Wilsgaard, Tom, Joakimsen, Ragnar Martin and Kamycheva, Elena. (2015). Genetic variations in the vitamin d receptor predict type 2 diabetes and myocardial infarction in a community-based population: The Tromsø Study. PLoS ONE. 10(12), pp. 1 - 13. https://doi.org/10.1371/journal.pone.0145359 journal-article 2015 ftaustraliancuni https://doi.org/10.1371/journal.pone.0145359 2023-08-11T15:11:23Z Background Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and mortality are well-studied, the effect of supplementation with vitamin D is uncertain. This may be related to genetic differences. Thus, rs7968585, a single nucleotide polymorphism (SNP) of the vitamin D receptor (VDR), has recently been reported as a predictor of composite health outcome. We therefore aimed to evaluate whether rs7968585 predicts separate clinical outcomes such as T2D, MI, cancer, and mortality in a community-based Norwegian population. Methods and Findings Measurements and DNA were obtained from the participants in the Tromsø Study in 1994–1995, registered with the outcomes of interest and a randomly selected control group. The impact of the rs7968585 genotypes was evaluated with Cox proportional hazards. A total of 8,461 subjects were included among whom 1,054 subjects were registered with T2D, 2,287 with MI, 3,166 with cancer, and 4,336 with death. Mean follow-up time from birth was 60.8 years for T2D and MI, 61.2 years for cancer, while mean follow-up time from examination date was 16.5 years for survival. Mean serum 25(OH)D levels did not differ across the rs7968585 genotypes. With the major homozygote genotype as reference, the minor homozygote subjects had hazard ratios of 1.25 (95% CI 1.05–1.49) for T2D and 1.14 (1.02–1.28) for MI (P = 0.011 and 0.023, respectively, without the Bonferroni correction). No significant interaction between serum 25(OH)D status and the rs7968585 genotype was found for any of the endpoints. Conclusions The VDR-related SNP rs7968585 minor allele is a significant and positive predictor for T2D and possibly for MI. Since the functional mechanism of this SNP is not yet understood, and the association with T2D is reported for the first time, confirmatory studies are needed. Article in Journal/Newspaper Tromsø Australian Catholic University: ACU Research Bank Tromsø PLOS ONE 10 12 e0145359 |
institution |
Open Polar |
collection |
Australian Catholic University: ACU Research Bank |
op_collection_id |
ftaustraliancuni |
language |
unknown |
description |
Background Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and mortality are well-studied, the effect of supplementation with vitamin D is uncertain. This may be related to genetic differences. Thus, rs7968585, a single nucleotide polymorphism (SNP) of the vitamin D receptor (VDR), has recently been reported as a predictor of composite health outcome. We therefore aimed to evaluate whether rs7968585 predicts separate clinical outcomes such as T2D, MI, cancer, and mortality in a community-based Norwegian population. Methods and Findings Measurements and DNA were obtained from the participants in the Tromsø Study in 1994–1995, registered with the outcomes of interest and a randomly selected control group. The impact of the rs7968585 genotypes was evaluated with Cox proportional hazards. A total of 8,461 subjects were included among whom 1,054 subjects were registered with T2D, 2,287 with MI, 3,166 with cancer, and 4,336 with death. Mean follow-up time from birth was 60.8 years for T2D and MI, 61.2 years for cancer, while mean follow-up time from examination date was 16.5 years for survival. Mean serum 25(OH)D levels did not differ across the rs7968585 genotypes. With the major homozygote genotype as reference, the minor homozygote subjects had hazard ratios of 1.25 (95% CI 1.05–1.49) for T2D and 1.14 (1.02–1.28) for MI (P = 0.011 and 0.023, respectively, without the Bonferroni correction). No significant interaction between serum 25(OH)D status and the rs7968585 genotype was found for any of the endpoints. Conclusions The VDR-related SNP rs7968585 minor allele is a significant and positive predictor for T2D and possibly for MI. Since the functional mechanism of this SNP is not yet understood, and the association with T2D is reported for the first time, confirmatory studies are needed. |
format |
Article in Journal/Newspaper |
author |
Zostautiene, Ieva Jorde, Rolf Schirmer, Henrik Mathiesen, Ellisiv Bøgeberg Njølstad, Inger Loechen, Maja-Lisa Wilsgaard, Tom Joakimsen, Ragnar Martin Kamycheva, Elena |
spellingShingle |
Zostautiene, Ieva Jorde, Rolf Schirmer, Henrik Mathiesen, Ellisiv Bøgeberg Njølstad, Inger Loechen, Maja-Lisa Wilsgaard, Tom Joakimsen, Ragnar Martin Kamycheva, Elena Genetic variations in the vitamin d receptor predict type 2 diabetes and myocardial infarction in a community-based population: The Tromsø Study |
author_facet |
Zostautiene, Ieva Jorde, Rolf Schirmer, Henrik Mathiesen, Ellisiv Bøgeberg Njølstad, Inger Loechen, Maja-Lisa Wilsgaard, Tom Joakimsen, Ragnar Martin Kamycheva, Elena |
author_sort |
Zostautiene, Ieva |
title |
Genetic variations in the vitamin d receptor predict type 2 diabetes and myocardial infarction in a community-based population: The Tromsø Study |
title_short |
Genetic variations in the vitamin d receptor predict type 2 diabetes and myocardial infarction in a community-based population: The Tromsø Study |
title_full |
Genetic variations in the vitamin d receptor predict type 2 diabetes and myocardial infarction in a community-based population: The Tromsø Study |
title_fullStr |
Genetic variations in the vitamin d receptor predict type 2 diabetes and myocardial infarction in a community-based population: The Tromsø Study |
title_full_unstemmed |
Genetic variations in the vitamin d receptor predict type 2 diabetes and myocardial infarction in a community-based population: The Tromsø Study |
title_sort |
genetic variations in the vitamin d receptor predict type 2 diabetes and myocardial infarction in a community-based population: the tromsø study |
publisher |
Public Library of Science |
publishDate |
2015 |
url |
https://acuresearchbank.acu.edu.au/download/6d55b56f97d261f379bc4ed19a0811ebb408be2905fd0b2d516414259de7d68e/247263/Zostautiene_2015_Genetic_variations_in_the_vitamin_d.pdf https://doi.org/10.1371/journal.pone.0145359 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://acuresearchbank.acu.edu.au/item/8861v/genetic-variations-in-the-vitamin-d-receptor-predict-type-2-diabetes-and-myocardial-infarction-in-a-community-based-population-the-troms-study ISSN:1932-6203 https://acuresearchbank.acu.edu.au/download/6d55b56f97d261f379bc4ed19a0811ebb408be2905fd0b2d516414259de7d68e/247263/Zostautiene_2015_Genetic_variations_in_the_vitamin_d.pdf https://doi.org/10.1371/journal.pone.0145359 Zostautiene, Ieva, Jorde, Rolf, Schirmer, Henrik, Mathiesen, Ellisiv Bøgeberg, Njølstad, Inger, Loechen, Maja-Lisa, Wilsgaard, Tom, Joakimsen, Ragnar Martin and Kamycheva, Elena. (2015). Genetic variations in the vitamin d receptor predict type 2 diabetes and myocardial infarction in a community-based population: The Tromsø Study. PLoS ONE. 10(12), pp. 1 - 13. https://doi.org/10.1371/journal.pone.0145359 |
op_doi |
https://doi.org/10.1371/journal.pone.0145359 |
container_title |
PLOS ONE |
container_volume |
10 |
container_issue |
12 |
container_start_page |
e0145359 |
_version_ |
1776204359160299520 |