Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø study 1979-2016
Objectives Elevated blood cholesterol is a modifiable risk factor for cardiovascular disease. Cholesterol level surveillance is necessary to study population disease burden, consider priorities for prevention and intervention and understand the effect of diet, lifestyle and treatment. Previous studi...
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ftaustraliancuni:oai:acuresearchbank.acu.edu.au:8701x 2023-09-05T13:23:46+02:00 Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø study 1979-2016 Hopstock, Laila Arnesdatter Bonaa, Kaare Harald Eggen, Anne Elise Grimsgaard, Sameline Jacobsen, Bjarne K. Loechen, Maja-Lisa Mathiesen, Ellisiv Bøgeberg Njølstad, Inger Wilsgaard, Tom 2017 application/pdf https://acuresearchbank.acu.edu.au/download/f0c610acce0e700d1411e6db754bf7f57744133a6fa4499db96e32401d5ce077/1154292/OA_Hopstock_2017_Longitudinal_and_secular_trends_in_total.pdf https://doi.org/10.1136/bmjopen-2016-015001 unknown BMJ https://acuresearchbank.acu.edu.au/item/8701x/longitudinal-and-secular-trends-in-total-cholesterol-levels-and-impact-of-lipid-lowering-drug-use-among-norwegian-women-and-men-born-in-1905-1977-in-the-population-based-troms-study-1979-2016 ISSN:2044-6055 https://acuresearchbank.acu.edu.au/download/f0c610acce0e700d1411e6db754bf7f57744133a6fa4499db96e32401d5ce077/1154292/OA_Hopstock_2017_Longitudinal_and_secular_trends_in_total.pdf https://doi.org/10.1136/bmjopen-2016-015001 Hopstock, Laila Arnesdatter, Bonaa, Kaare Harald, Eggen, Anne Elise, Grimsgaard, Sameline, Jacobsen, Bjarne K., Loechen, Maja-Lisa, Mathiesen, Ellisiv Bøgeberg, Njølstad, Inger and Wilsgaard, Tom. (2017). Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø study 1979-2016. BMJ Open. 7(8), pp. 1 - 9. https://doi.org/10.1136/bmjopen-2016-015001 CC BY 4.0 journal-article 2017 ftaustraliancuni https://doi.org/10.1136/bmjopen-2016-015001 2023-08-11T15:31:12Z Objectives Elevated blood cholesterol is a modifiable risk factor for cardiovascular disease. Cholesterol level surveillance is necessary to study population disease burden, consider priorities for prevention and intervention and understand the effect of diet, lifestyle and treatment. Previous studies show a cholesterol decline in recent decades but lack data to follow individuals born in different decades throughout life. Methods We investigated changes in age-specific and birth cohort-specific total cholesterol (TC) levels in 43 710 women and men born in 1905–1977 (aged 20–95 years at screening) in the population-based Tromsø Study. Fifty-nine per cent of the participants had more than one and up to six repeated TC measurements during 1979–2016. Linear mixed models were used to test for time trends. Results Mean TC decreased during 1979–2016 in both women and men and in all age groups. The decrease in TC in age group 40–49 years was 1.2 mmol/L in women and 1.0 mmol/L in men. Both the 80th and the 20th percentile of the population TC distribution decreased in both sexes and all age groups. Longitudinal analysis showed that TC increased with age to a peak around middle age followed by a decrease. At any given age, TC significantly decreased with increase in year born. Lipid-lowering drug use was rare in 1994, increased thereafter, but was low ( Conclusions We found a substantial decrease in mean TC levels in the general population between 1979 and 2016 in all age groups. In birth cohorts, TC increased with age to a peak around middle age followed by a decrease. Article in Journal/Newspaper Tromsø Australian Catholic University: ACU Research Bank Tromsø BMJ Open 7 8 e015001 |
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Australian Catholic University: ACU Research Bank |
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ftaustraliancuni |
language |
unknown |
description |
Objectives Elevated blood cholesterol is a modifiable risk factor for cardiovascular disease. Cholesterol level surveillance is necessary to study population disease burden, consider priorities for prevention and intervention and understand the effect of diet, lifestyle and treatment. Previous studies show a cholesterol decline in recent decades but lack data to follow individuals born in different decades throughout life. Methods We investigated changes in age-specific and birth cohort-specific total cholesterol (TC) levels in 43 710 women and men born in 1905–1977 (aged 20–95 years at screening) in the population-based Tromsø Study. Fifty-nine per cent of the participants had more than one and up to six repeated TC measurements during 1979–2016. Linear mixed models were used to test for time trends. Results Mean TC decreased during 1979–2016 in both women and men and in all age groups. The decrease in TC in age group 40–49 years was 1.2 mmol/L in women and 1.0 mmol/L in men. Both the 80th and the 20th percentile of the population TC distribution decreased in both sexes and all age groups. Longitudinal analysis showed that TC increased with age to a peak around middle age followed by a decrease. At any given age, TC significantly decreased with increase in year born. Lipid-lowering drug use was rare in 1994, increased thereafter, but was low ( Conclusions We found a substantial decrease in mean TC levels in the general population between 1979 and 2016 in all age groups. In birth cohorts, TC increased with age to a peak around middle age followed by a decrease. |
format |
Article in Journal/Newspaper |
author |
Hopstock, Laila Arnesdatter Bonaa, Kaare Harald Eggen, Anne Elise Grimsgaard, Sameline Jacobsen, Bjarne K. Loechen, Maja-Lisa Mathiesen, Ellisiv Bøgeberg Njølstad, Inger Wilsgaard, Tom |
spellingShingle |
Hopstock, Laila Arnesdatter Bonaa, Kaare Harald Eggen, Anne Elise Grimsgaard, Sameline Jacobsen, Bjarne K. Loechen, Maja-Lisa Mathiesen, Ellisiv Bøgeberg Njølstad, Inger Wilsgaard, Tom Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø study 1979-2016 |
author_facet |
Hopstock, Laila Arnesdatter Bonaa, Kaare Harald Eggen, Anne Elise Grimsgaard, Sameline Jacobsen, Bjarne K. Loechen, Maja-Lisa Mathiesen, Ellisiv Bøgeberg Njølstad, Inger Wilsgaard, Tom |
author_sort |
Hopstock, Laila Arnesdatter |
title |
Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø study 1979-2016 |
title_short |
Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø study 1979-2016 |
title_full |
Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø study 1979-2016 |
title_fullStr |
Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø study 1979-2016 |
title_full_unstemmed |
Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø study 1979-2016 |
title_sort |
longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among norwegian women and men born in 1905-1977 in the population-based tromsø study 1979-2016 |
publisher |
BMJ |
publishDate |
2017 |
url |
https://acuresearchbank.acu.edu.au/download/f0c610acce0e700d1411e6db754bf7f57744133a6fa4499db96e32401d5ce077/1154292/OA_Hopstock_2017_Longitudinal_and_secular_trends_in_total.pdf https://doi.org/10.1136/bmjopen-2016-015001 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://acuresearchbank.acu.edu.au/item/8701x/longitudinal-and-secular-trends-in-total-cholesterol-levels-and-impact-of-lipid-lowering-drug-use-among-norwegian-women-and-men-born-in-1905-1977-in-the-population-based-troms-study-1979-2016 ISSN:2044-6055 https://acuresearchbank.acu.edu.au/download/f0c610acce0e700d1411e6db754bf7f57744133a6fa4499db96e32401d5ce077/1154292/OA_Hopstock_2017_Longitudinal_and_secular_trends_in_total.pdf https://doi.org/10.1136/bmjopen-2016-015001 Hopstock, Laila Arnesdatter, Bonaa, Kaare Harald, Eggen, Anne Elise, Grimsgaard, Sameline, Jacobsen, Bjarne K., Loechen, Maja-Lisa, Mathiesen, Ellisiv Bøgeberg, Njølstad, Inger and Wilsgaard, Tom. (2017). Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Tromsø study 1979-2016. BMJ Open. 7(8), pp. 1 - 9. https://doi.org/10.1136/bmjopen-2016-015001 |
op_rights |
CC BY 4.0 |
op_doi |
https://doi.org/10.1136/bmjopen-2016-015001 |
container_title |
BMJ Open |
container_volume |
7 |
container_issue |
8 |
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e015001 |
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1776204355296296960 |