Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population
Background: Few studies have used individual person data to study whether contemporary trends in the incidence of coronary heart disease are associated with changes in modifiable coronary risk factors. Methods and Results: We identified 29 582 healthy men and women ≥25 years of age who participated...
Published in: | Circulation |
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Lippincott Williams & Wilkins
2016
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Online Access: | https://acuresearchbank.acu.edu.au/download/452774b4c3dcd3eb052c77c2ece0141d950acb66b7fd8913471ef70a3879ed25/550567/Mannsverk_2015_Trends_in_modifiable_risk_factors_are.pdf https://doi.org/10.1161/CIRCULATIONAHA.115.016960 |
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ftaustraliancuni:oai:acuresearchbank.acu.edu.au:86xw1 2023-09-05T13:23:47+02:00 Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population Mannsverk, Jan Wilsgaard, Tom Mathiesen, Ellisiv Bøgeberg Løchen, Maja-Lisa Rasmussen, Knut Thelle, Dag S. Njølstad, Inger Hopstock, Laila Arnesdatter Bønaa, Kaare Harald 2016 application/pdf https://acuresearchbank.acu.edu.au/download/452774b4c3dcd3eb052c77c2ece0141d950acb66b7fd8913471ef70a3879ed25/550567/Mannsverk_2015_Trends_in_modifiable_risk_factors_are.pdf https://doi.org/10.1161/CIRCULATIONAHA.115.016960 unknown Lippincott Williams & Wilkins https://acuresearchbank.acu.edu.au/item/86xw1/trends-in-modifiable-risk-factors-are-associated-with-declining-incidence-of-hospitalized-and-nonhospitalized-acute-coronary-heart-disease-in-a-population ISSN:0009-7322 https://acuresearchbank.acu.edu.au/download/452774b4c3dcd3eb052c77c2ece0141d950acb66b7fd8913471ef70a3879ed25/550567/Mannsverk_2015_Trends_in_modifiable_risk_factors_are.pdf https://doi.org/10.1161/CIRCULATIONAHA.115.016960 Mannsverk, Jan, Wilsgaard, Tom, Mathiesen, Ellisiv Bøgeberg, Løchen, Maja-Lisa, Rasmussen, Knut, Thelle, Dag S., Njølstad, Inger, Hopstock, Laila Arnesdatter and Bønaa, Kaare Harald. (2016). Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population. Circulation. 133(1), pp. 74 - 81. https://doi.org/10.1161/CIRCULATIONAHA.115.016960 coronary disease epidemiology incidence mortality myocardial infarction risk factors journal-article 2016 ftaustraliancuni https://doi.org/10.1161/CIRCULATIONAHA.115.016960 2023-08-11T15:33:32Z Background: Few studies have used individual person data to study whether contemporary trends in the incidence of coronary heart disease are associated with changes in modifiable coronary risk factors. Methods and Results: We identified 29 582 healthy men and women ≥25 years of age who participated in 3 population surveys conducted between 1994 and 2008 in Tromsø, Norway. Age- and sex-adjusted incidence rates were calculated for coronary heart disease overall, out-of-hospital sudden death, and hospitalized ST-segment–elevation and non–ST-segment–elevation myocardial infarction. We measured coronary risk factors at each survey and estimated the relationship between changes in risk factors and changes in incidence trends. A total of 1845 participants had an incident acute coronary heart disease event during 375 064 person-years of follow-up from 1994 to 2010. The age- and sex-adjusted incidence of total coronary heart disease decreased by 3% ( 95% confidence interval, 2.0–4.0; P < 0.001 ) each year. This decline was driven by decreases in out-of-hospital sudden death and hospitalized ST-segment–elevation myocardial infarction. Changes in coronary risk factors accounted for 66% ( 95% confidence interval, 48–97; P < 0.001 ) of the decline in total coronary heart disease. Favorable changes in cholesterol contributed 32% to the decline, whereas blood pressure, smoking, and physical activity each contributed 14%, 13%, and 9%, respectively. Conclusions: We observed a substantial decline in the incidence of coronary heart disease that was driven by reductions in out-of-hospital sudden death and hospitalized ST-segment–elevation myocardial infarction. Changes in modifiable coronary risk factors accounted for 66% of the decline in coronary heart disease events. Article in Journal/Newspaper Tromsø Australian Catholic University: ACU Research Bank Norway Tromsø Circulation 133 1 74 81 |
institution |
Open Polar |
collection |
Australian Catholic University: ACU Research Bank |
op_collection_id |
ftaustraliancuni |
language |
unknown |
topic |
coronary disease epidemiology incidence mortality myocardial infarction risk factors |
spellingShingle |
coronary disease epidemiology incidence mortality myocardial infarction risk factors Mannsverk, Jan Wilsgaard, Tom Mathiesen, Ellisiv Bøgeberg Løchen, Maja-Lisa Rasmussen, Knut Thelle, Dag S. Njølstad, Inger Hopstock, Laila Arnesdatter Bønaa, Kaare Harald Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population |
topic_facet |
coronary disease epidemiology incidence mortality myocardial infarction risk factors |
description |
Background: Few studies have used individual person data to study whether contemporary trends in the incidence of coronary heart disease are associated with changes in modifiable coronary risk factors. Methods and Results: We identified 29 582 healthy men and women ≥25 years of age who participated in 3 population surveys conducted between 1994 and 2008 in Tromsø, Norway. Age- and sex-adjusted incidence rates were calculated for coronary heart disease overall, out-of-hospital sudden death, and hospitalized ST-segment–elevation and non–ST-segment–elevation myocardial infarction. We measured coronary risk factors at each survey and estimated the relationship between changes in risk factors and changes in incidence trends. A total of 1845 participants had an incident acute coronary heart disease event during 375 064 person-years of follow-up from 1994 to 2010. The age- and sex-adjusted incidence of total coronary heart disease decreased by 3% ( 95% confidence interval, 2.0–4.0; P < 0.001 ) each year. This decline was driven by decreases in out-of-hospital sudden death and hospitalized ST-segment–elevation myocardial infarction. Changes in coronary risk factors accounted for 66% ( 95% confidence interval, 48–97; P < 0.001 ) of the decline in total coronary heart disease. Favorable changes in cholesterol contributed 32% to the decline, whereas blood pressure, smoking, and physical activity each contributed 14%, 13%, and 9%, respectively. Conclusions: We observed a substantial decline in the incidence of coronary heart disease that was driven by reductions in out-of-hospital sudden death and hospitalized ST-segment–elevation myocardial infarction. Changes in modifiable coronary risk factors accounted for 66% of the decline in coronary heart disease events. |
format |
Article in Journal/Newspaper |
author |
Mannsverk, Jan Wilsgaard, Tom Mathiesen, Ellisiv Bøgeberg Løchen, Maja-Lisa Rasmussen, Knut Thelle, Dag S. Njølstad, Inger Hopstock, Laila Arnesdatter Bønaa, Kaare Harald |
author_facet |
Mannsverk, Jan Wilsgaard, Tom Mathiesen, Ellisiv Bøgeberg Løchen, Maja-Lisa Rasmussen, Knut Thelle, Dag S. Njølstad, Inger Hopstock, Laila Arnesdatter Bønaa, Kaare Harald |
author_sort |
Mannsverk, Jan |
title |
Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population |
title_short |
Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population |
title_full |
Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population |
title_fullStr |
Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population |
title_full_unstemmed |
Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population |
title_sort |
trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population |
publisher |
Lippincott Williams & Wilkins |
publishDate |
2016 |
url |
https://acuresearchbank.acu.edu.au/download/452774b4c3dcd3eb052c77c2ece0141d950acb66b7fd8913471ef70a3879ed25/550567/Mannsverk_2015_Trends_in_modifiable_risk_factors_are.pdf https://doi.org/10.1161/CIRCULATIONAHA.115.016960 |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
https://acuresearchbank.acu.edu.au/item/86xw1/trends-in-modifiable-risk-factors-are-associated-with-declining-incidence-of-hospitalized-and-nonhospitalized-acute-coronary-heart-disease-in-a-population ISSN:0009-7322 https://acuresearchbank.acu.edu.au/download/452774b4c3dcd3eb052c77c2ece0141d950acb66b7fd8913471ef70a3879ed25/550567/Mannsverk_2015_Trends_in_modifiable_risk_factors_are.pdf https://doi.org/10.1161/CIRCULATIONAHA.115.016960 Mannsverk, Jan, Wilsgaard, Tom, Mathiesen, Ellisiv Bøgeberg, Løchen, Maja-Lisa, Rasmussen, Knut, Thelle, Dag S., Njølstad, Inger, Hopstock, Laila Arnesdatter and Bønaa, Kaare Harald. (2016). Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population. Circulation. 133(1), pp. 74 - 81. https://doi.org/10.1161/CIRCULATIONAHA.115.016960 |
op_doi |
https://doi.org/10.1161/CIRCULATIONAHA.115.016960 |
container_title |
Circulation |
container_volume |
133 |
container_issue |
1 |
container_start_page |
74 |
op_container_end_page |
81 |
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1776204364670566400 |